PEPR1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEPR1_ARATH
• UniProt AC: Q9SSL9
• Protein Name: Leucine-rich repeat receptor-like protein kinase PEPR1
• Gene Name: PEPR1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1123
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Acts as a receptor for PEP defense peptides. Unlike typical immune receptors, senses an endogenous elicitor that potentiates pathogen-associated molecular pattern (PAMP)-inducible plant responses. Involved in PAMP-triggered immunity (PTI) signaling. Interacts with and phosphorylates the kinase BIK1, a central rate-limiting kinase in PTI signaling. [PubMed: 23431184]
• Protein Sequence: MKNLGGLFKILLLFFCLFLSTHIISVSCLNSDGLTLLSLLKHLDRVPPQVTSTWKINASEATPCNWFGITCDDSKNVASLNFTRSRVSGQLGPEIGELKSLQILDLSTNNFSGTIPSTLGNCTKLATLDLSENGFSDKIPDTLDSLKRLEVLYLYINFLTGELPESLFRIPKLQVLYLDYNNLTGPIPQSIGDAKELVELSMYANQFSGNIPESIGNSSSLQILYLHRNKLVGSLPESLNLLGNLTTLFVGNNSLQGPVRFGSPNCKNLLTLDLSYNEFEGGVPPALGNCSSLDALVIVSGNLSGTIPSSLGMLKNLTILNLSENRLSGSIPAELGNCSSLNLLKLNDNQLVGGIPSALGKLRKLESLELFENRFSGEIPIEIWKSQSLTQLLVYQNNLTGELPVEMTEMKKLKIATLFNNSFYGAIPPGLGVNSSLEEVDFIGNKLTGEIPPNLCHGRKLRILNLGSNLLHGTIPASIGHCKTIRRFILRENNLSGLLPEFSQDHSLSFLDFNSNNFEGPIPGSLGSCKNLSSINLSRNRFTGQIPPQLGNLQNLGYMNLSRNLLEGSLPAQLSNCVSLERFDVGFNSLNGSVPSNFSNWKGLTTLVLSENRFSGGIPQFLPELKKLSTLQIARNAFGGEIPSSIGLIEDLIYDLDLSGNGLTGEIPAKLGDLIKLTRLNISNNNLTGSLSVLKGLTSLLHVDVSNNQFTGPIPDNLEGQLLSEPSSFSGNPNLCIPHSFSASNNSRSALKYCKDQSKSRKSGLSTWQIVLIAVLSSLLVLVVVLALVFICLRRRKGRPEKDAYVFTQEEGPSLLLNKVLAATDNLNEKYTIGRGAHGIVYRASLGSGKVYAVKRLVFASHIRANQSMMREIDTIGKVRHRNLIKLEGFWLRKDDGLMLYRYMPKGSLYDVLHGVSPKENVLDWSARYNVALGVAHGLAYLHYDCHPPIVHRDIKPENILMDSDLEPHIGDFGLARLLDDSTVSTATVTGTTGYIAPENAFKTVRGRESDVYSYGVVLLELVTRKRAVDKSFPESTDIVSWVRSALSSSNNNVEDMVTTIVDPILVDELLDSSLREQVMQVTELALSCTQQDPAMRPTMRDAVKLLEDVKHLARSCSSDSVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	N-linked_Glycosylation	VTSTWKINASEATPC CCEEEEECCCCCCCC	33.42	-
81	N-linked_Glycosylation	SKNVASLNFTRSRVS CCCEEEEEEEEHHHC	33.47	-
110	N-linked_Glycosylation	ILDLSTNNFSGTIPS EEECCCCCCCCCCCC	32.33	-
121	N-linked_Glycosylation	TIPSTLGNCTKLATL CCCCCCCCCCEEEEE	33.14	-
182	N-linked_Glycosylation	VLYLDYNNLTGPIPQ EEEEECCCCCCCCCC	32.52	-
217	N-linked_Glycosylation	NIPESIGNSSSLQIL CCCHHHCCCCCEEEE	36.73	-
244	N-linked_Glycosylation	ESLNLLGNLTTLFVG HHHHHHCCCEEEEEC	33.90	-
252	N-linked_Glycosylation	LTTLFVGNNSLQGPV CEEEEECCCCCCCCE	29.61	-
289	N-linked_Glycosylation	GVPPALGNCSSLDAL CCCCCCCCCCCCCEE	24.29	-
302	N-linked_Glycosylation	ALVIVSGNLSGTIPS EEEEECCCCCCCCCH	24.43	-
316	N-linked_Glycosylation	SSLGMLKNLTILNLS HHHHHHCCCEEEECC	38.15	-
321	N-linked_Glycosylation	LKNLTILNLSENRLS HCCCEEEECCCCCCC	37.36	-
337	N-linked_Glycosylation	SIPAELGNCSSLNLL CCCHHHCCCCCCCEE	34.81	-
398	N-linked_Glycosylation	QLLVYQNNLTGELPV EEEEEECCCCCCCCC	24.37	-
420	N-linked_Glycosylation	LKIATLFNNSFYGAI CEEEECCCCCCCCCC	46.48	-
434	N-linked_Glycosylation	IPPGLGVNSSLEEVD CCCCCCCCCCCCEEC	24.88	-
494	N-linked_Glycosylation	RFILRENNLSGLLPE HHHHHHCCCCCCCCC	30.72	-
531	N-linked_Glycosylation	GSLGSCKNLSSINLS CCCCCCCCCCCCCCC	49.86	-
536	N-linked_Glycosylation	CKNLSSINLSRNRFT CCCCCCCCCCCCCCC	33.63	-
560	N-linked_Glycosylation	LQNLGYMNLSRNLLE CHHCCCCCCCCCHHC	26.78	-
591	N-linked_Glycosylation	DVGFNSLNGSVPSNF EECHHHCCCCCCCCC	40.28	-
597	N-linked_Glycosylation	LNGSVPSNFSNWKGL CCCCCCCCCCCCCCC	37.99	-
681	N-linked_Glycosylation	LIKLTRLNISNNNLT HEEEEEEECCCCCCC	32.14	-
686	N-linked_Glycosylation	RLNISNNNLTGSLSV EEECCCCCCCCCHHH	43.14	-
745	N-linked_Glycosylation	PHSFSASNNSRSALK CCCCCCCCCCHHHHH	50.65	-
824	Phosphorylation	LNKVLAATDNLNEKY HHHHHHHCCCCCCCC	21.58	-
848	Phosphorylation	VYRASLGSGKVYAVK EEEEECCCCCEEEEE	40.51	19880383
901	Phosphorylation	KDDGLMLYRYMPKGS CCCCEEEEEEECCCC	5.92	-
941	Phosphorylation	GVAHGLAYLHYDCHP HHHHHHHHHCCCCCC	10.07	-
995	Phosphorylation	TVTGTTGYIAPENAF EEECCCCEECCCCCC	7.57	-
1118	Phosphorylation	KHLARSCSSDSVR-- HHHHHHCCCCCCC--	38.13	25561503
1119	Phosphorylation	HLARSCSSDSVR--- HHHHHCCCCCCC---	37.93	25561503
1121	Phosphorylation	ARSCSSDSVR----- HHHCCCCCCC-----	23.03	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEPR1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEPR1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEPR1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BIK1_ARATH	BIK1	physical	23431184
PEP1_ARATH	PROPEP1	physical	25475059
BAK1_ARATH	BAK1	physical	25475059

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.