dbPTM

PEDF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PEDF_MOUSE
UniProt AC	P97298
Protein Name	Pigment epithelium-derived factor
Gene Name	Serpinf1
Organism	Mus musculus (Mouse).
Sequence Length	417
Subcellular Localization	Secreted. Melanosome.
Protein Description	Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity..
Protein Sequence	MQALVLLLWTGALLGHGSSQNVPSSSEGSPVPDSTGEPVEEEDPFFKVPVNKLAAAVSNFGYDLYRLRSSASPTGNVLLSPLSVATALSALSLGAEHRTESVIHRALYYDLITNPDIHSTYKELLASVTAPEKNLKSASRIVFERKLRVKSSFVAPLEKSYGTRPRILTGNPRVDLQEINNWVQAQMKGKIARSTREMPSALSILLLGVAYFKGQWVTKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGSMSIIFFLPLTVTQNLTMIEESLTSEFIHDIDRELKTIQAVLTVPKLKLSFEGELTKSLQDMKLQSLFESPDFSKITGKPVKLTQVEHRAAFEWNEEGAGSSPSPGLQPVRLTFPLDYHLNQPFLFVLRDTDTGALLFIGRILDPSST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Pyrrolidone_carboxylic_acid	LLGHGSSQNVPSSSE HHCCCCCCCCCCCCC	57.55	-
20	Pyrrolidone_carboxylic_acid	LLGHGSSQNVPSSSE HHCCCCCCCCCCCCC	57.55	-
24	Phosphorylation	GSSQNVPSSSEGSPV CCCCCCCCCCCCCCC	42.06	-
69	Phosphorylation	YDLYRLRSSASPTGN CCHHHHHCCCCCCCC	34.54	26239621
89	Phosphorylation	LSVATALSALSLGAE HHHHHHHHHHHCCCC	25.38	26239621
92	Phosphorylation	ATALSALSLGAEHRT HHHHHHHHCCCCCCC	25.19	26239621
284	N-linked_Glycosylation	LPLTVTQNLTMIEES EEEEECCCCHHHHHH	28.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PEDF_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PEDF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PEDF_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PEDF_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PEDF_MOUSE

Related Literatures of Post-Translational Modification