PEBP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEBP4_HUMAN
• UniProt AC: Q96S96
• Protein Name: Phosphatidylethanolamine-binding protein 4
• Gene Name: PEBP4
• Organism: Homo sapiens (Human).
• Sequence Length: 227
• Subcellular Localization: Lysosome .
• Protein Description: Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization..
• Protein Sequence: MGWTMRLVTAALLLGLMMVVTGDEDENSPCAHEALLDEDTLFCQGLEVFYPELGNIGCKVVPDCNNYRQKITSWMEPIVKFPGAVDGATYILVMVDPDAPSRAEPRQRFWRHWLVTDIKGADLKKGKIQGQELSAYQAPSPPAHSGFHRYQFFVYLQEGKVISLLPKENKTRGSWKMDRFLNRFHLGEPEASTQFMTQNYQDSPTLQAPRERASEPKHKNQAEIAAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Acetylation	DCNNYRQKITSWMEP CCCCHHHHHHHHHHC	38.66	25038526
72	Phosphorylation	NNYRQKITSWMEPIV CCHHHHHHHHHHCHH	24.30	23898821
73	Phosphorylation	NYRQKITSWMEPIVK CHHHHHHHHHHCHHC	28.09	23898821
163	Phosphorylation	LQEGKVISLLPKENK EECCCEEEEEECCCC	27.17	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEBP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEBP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEBP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MP2K1_HUMAN	MAP2K1	physical	15302887
RAF1_HUMAN	RAF1	physical	15302887
RAF1_HUMAN	RAF1	physical	19197339

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.