PEBP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEBP1_RAT
• UniProt AC: P31044
• Protein Name: Phosphatidylethanolamine-binding protein 1
• Gene Name: Pebp1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 187
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).; HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor..
• Protein Sequence: MAADISQWAGPLSLQEVDEPPQHALRVDYGGVTVDELGKVLTPTQVMNRPSSISWDGLDPGKLYTLVLTDPDAPSRKDPKFREWHHFLVVNMKGNDISSGTVLSEYVGSGPPKDTGLHRYVWLVYEQEQPLNCDEPILSNKSGDNRGKFKVESFRKKYHLGAPVAGTCFQAEWDDSVPKLHDQLAGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAADISQWA ------CCCCHHHHC	17.53	1611510
6	Phosphorylation	--MAADISQWAGPLS --CCCCHHHHCCCCC	21.88	23984901
13	Phosphorylation	SQWAGPLSLQEVDEP HHHCCCCCCCCCCCC	31.01	27097102
42	Phosphorylation	DELGKVLTPTQVMNR HHHCCCCCCHHHCCC	27.55	27097102
44	Phosphorylation	LGKVLTPTQVMNRPS HCCCCCCHHHCCCCC	28.67	29779826
51	Phosphorylation	TQVMNRPSSISWDGL HHHCCCCCCCCCCCC	36.75	23991683
52	Phosphorylation	QVMNRPSSISWDGLD HHCCCCCCCCCCCCC	24.27	23991683
54	Phosphorylation	MNRPSSISWDGLDPG CCCCCCCCCCCCCCC	22.51	27097102
77	Acetylation	DPDAPSRKDPKFREW CCCCCCCCCCCCCCC	80.75	22902405
80	Acetylation	APSRKDPKFREWHHF CCCCCCCCCCCCEEE	68.16	22902405
98	Phosphorylation	NMKGNDISSGTVLSE ECCCCCCCCCEEHHH	26.11	25575281
99	Phosphorylation	MKGNDISSGTVLSEY CCCCCCCCCEEHHHC	38.53	25575281
101	Phosphorylation	GNDISSGTVLSEYVG CCCCCCCEEHHHCCC	21.88	25575281
104	Phosphorylation	ISSGTVLSEYVGSGP CCCCEEHHHCCCCCC	23.65	25575281
106	Phosphorylation	SGTVLSEYVGSGPPK CCEEHHHCCCCCCCC	13.51	25575281
113	Acetylation	YVGSGPPKDTGLHRY CCCCCCCCCCCCCEE	71.68	22902405
148	Acetylation	KSGDNRGKFKVESFR CCCCCCCCEEEEHHH	38.48	22902405
150	Acetylation	GDNRGKFKVESFRKK CCCCCCEEEEHHHHH	48.88	22902405
153	Phosphorylation	RGKFKVESFRKKYHL CCCEEEEHHHHHCCC	33.08	29779826

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
153	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
153	S	Phosphorylation	Kinase	PKCB	P68403	PSP
153	S	Phosphorylation	Kinase	PRKCB	P68403-2	GPS
153	S	Phosphorylation	Kinase	PRKCG	P63318	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEBP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEBP1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M3K7_MOUSE	Map3k7	physical	11585904
IKKB_HUMAN	IKBKB	physical	11585904
IKKA_HUMAN	CHUK	physical	11585904
M3K7_HUMAN	MAP3K7	physical	11585904

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Purification and structural analysis of hippocampal cholinergicneurostimulating peptide.";
Ojika K., Kojima S., Ueki Y., Fukushima N., Hayashi K., Yamamoto M.;
Brain Res. 572:164-171(1992).
Cited for: PROTEIN SEQUENCE OF 2-12, AND ACETYLATION AT ALA-2.
PubMed: 1611510