PDXK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDXK_MOUSE
• UniProt AC: Q8K183
• Protein Name: Pyridoxal kinase
• Gene Name: Pdxk
• Organism: Mus musculus (Mouse).
• Sequence Length: 312
• Subcellular Localization: Cytoplasm.
• Protein Description: Required for synthesis of pyridoxal-5-phosphate from vitamin B6..
• Protein Sequence: MEGECRVLSIQSHVVRGYVGNRAAMFPLQVLGFEVDAVNSVQFSNHTGYAHWKGQVLKSQELHELYEGLKVNDVNKYDYVLTGYTRDKSFLAMVVDIVRELKQQNSRLVYVCDPVMGDKWNGEGSMYVPQDLLPVYRDKVVPVADIITPNQFEAELLSGRKIHSQEEAFEVMDMLHCMGPDTVVITSSDLPSSQGSDYLIALGSQRMRKPDGSTVTQRIRMEMRKVEAVFVGTGDLFAAMLLAWTHKHPDNLKVACEKTVSAMQHVLQRTIRCAKAEAGEGQKPSPAQLELRMVQSKRDIEDPEIVVQATVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGECRVL -------CCCCEEEE	15.66	-
58	Malonylation	HWKGQVLKSQELHEL CHHCEEECHHHHHHH	51.76	26320211
59	Phosphorylation	WKGQVLKSQELHELY HHCEEECHHHHHHHH	25.40	25521595
76	Ubiquitination	LKVNDVNKYDYVLTG CCCCCCCCCCEEEEE	39.07	22790023
89	Phosphorylation	TGYTRDKSFLAMVVD EEECCCHHHHHHHHH	29.76	29899451
139	Ubiquitination	LLPVYRDKVVPVADI HHHHCCCCEEEHHHC	35.81	22790023
164	Phosphorylation	LSGRKIHSQEEAFEV HHCCCCCCHHHHHHH	42.64	-
209	Ubiquitination	LGSQRMRKPDGSTVT ECCCCCCCCCCCCHH	37.81	27667366
213	Phosphorylation	RMRKPDGSTVTQRIR CCCCCCCCCHHHHHH	27.38	-
258	Ubiquitination	NLKVACEKTVSAMQH CHHHHHHHHHHHHHH	54.86	22790023
258	Acetylation	NLKVACEKTVSAMQH CHHHHHHHHHHHHHH	54.86	22826441
283	Ubiquitination	AEAGEGQKPSPAQLE HHCCCCCCCCHHHHH	59.32	22790023
285	Phosphorylation	AGEGQKPSPAQLELR CCCCCCCCHHHHHHE	39.64	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDXK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDXK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDXK_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PDXK_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.