PDIP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDIP3_MOUSE
• UniProt AC: Q8BG81
• Protein Name: Polymerase delta-interacting protein 3
• Gene Name: Poldip3
• Organism: Mus musculus (Mouse).
• Sequence Length: 420
• Subcellular Localization: Nucleus. Nucleus speckle. Cytoplasm. Nucleocytoplasmic shuttling protein..
• Protein Description: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex (By similarity)..
• Protein Sequence: MADLSLDELIRKRGTAAKGRLSVRPGIGGVRSRVGIQHSLVNQPARTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGKVQDAREMLNSRKQQGTVPQKPRQVADAREKISLKRRSPAAFTSPPIGTVTPALKLTKTIQVPQQKAMVPLHAHPAGMRINVVNNHQAKQNLYDLDEDDDIVVPVPPKQMKFAATGSLVHHMTGLSSSKLSMSKALPLTKVVQNDAYTAPVLPSSVRTKALTSMSRTLVNKEEPPKELPPAEPVLSPLEGTKMTVNNLHPRVTEEDIVELFCVCGALKRARLVHPGVAEVVFVKKDDAITAYKKYNNRCLDGQPMKCNLHMNGNVITSDQPILLRLSDSPSVKKESELPRRGNPASSNPPAEVDPDTVLRALFKSSGASVTTQPTEFKIKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADLSLDEL ------CCCCCHHHH	26.84	-
5	Phosphorylation	---MADLSLDELIRK ---CCCCCHHHHHHH	34.03	28066266
22	Phosphorylation	TAAKGRLSVRPGIGG CCCCCCCEECCCCCC	18.08	26824392
33	Methylation	GIGGVRSRVGIQHSL CCCCHHHHHCCCHHH	21.81	-
39	Phosphorylation	SRVGIQHSLVNQPAR HHHCCCHHHCCCCCC	20.03	29176673
63	Phosphorylation	ARQKIGLSDARLKLG HHHHHCCCHHHHHHC	24.82	24759943
127	Phosphorylation	KISLKRRSPAAFTSP HHCCCCCCCCCCCCC	23.95	26824392
132	Phosphorylation	RRSPAAFTSPPIGTV CCCCCCCCCCCCCCC	35.28	23984901
133	Phosphorylation	RSPAAFTSPPIGTVT CCCCCCCCCCCCCCC	23.40	22942356
138	Phosphorylation	FTSPPIGTVTPALKL CCCCCCCCCCCCEEE	23.17	25619855
140	Phosphorylation	SPPIGTVTPALKLTK CCCCCCCCCCEEEEE	11.59	25619855
206	Phosphorylation	MKFAATGSLVHHMTG CCEEECCCHHHHHHC	23.90	29514104
212	Phosphorylation	GSLVHHMTGLSSSKL CCHHHHHHCCCCCCC	30.52	28576409
215	Phosphorylation	VHHMTGLSSSKLSMS HHHHHCCCCCCCCHH	33.63	-
217	Phosphorylation	HMTGLSSSKLSMSKA HHHCCCCCCCCHHCC	33.95	-
244	Phosphorylation	TAPVLPSSVRTKALT CCCCCCHHHHHHHHH	17.43	-
275	Phosphorylation	PPAEPVLSPLEGTKM CCCCCCCCCCCCCCC	27.89	29514104
366	Phosphorylation	QPILLRLSDSPSVKK CCEEEEECCCCCCCC	29.61	25777480
368	Phosphorylation	ILLRLSDSPSVKKES EEEEECCCCCCCCHH	18.72	26824392
370	Phosphorylation	LRLSDSPSVKKESEL EEECCCCCCCCHHCC	50.99	26745281
372	Acetylation	LSDSPSVKKESELPR ECCCCCCCCHHCCCC	55.98	6568213
385	Phosphorylation	PRRGNPASSNPPAEV CCCCCCCCCCCCCCC	31.72	-
408	Phosphorylation	LFKSSGASVTTQPTE HHHCCCCCCCCCCCE	24.42	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDIP3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDIP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDIP3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PDIP3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.