PDIA6_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDIA6_RAT
• UniProt AC: Q63081
• Protein Name: Protein disulfide-isomerase A6
• Gene Name: Pdia6
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 440
• Subcellular Localization: Endoplasmic reticulum lumen . Cell membrane . Melanosome .
• Protein Description: May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin..
• Protein Sequence: MARLVLGLVSCTFFLAVSALYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAASALKDVVKVGAVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRGDSSSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQVLASRYGIKGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGATGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGSFPNITPREPWDGKDGELPVEDDIDLSDVELDDLEKDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Acetylation	RLTPEWKKAASALKD HCCHHHHHHHHHHHH	50.70	22902405
88	Phosphorylation	VNADKHQSLGGQYGV CCCCCCHHHCCCCCC	28.80	17564427
110	Succinylation	IFGANKNKPEDYQGG EEECCCCCCCCCCCC	51.93	26843850
129	Phosphorylation	AIVDAALSALRQLVK HHHHHHHHHHHHHHH	22.11	28432305
156	Phosphorylation	GKQGRGDSSSKKDVV CCCCCCCCCCCCCEE	39.06	-
158	Phosphorylation	QGRGDSSSKKDVVEL CCCCCCCCCCCEEEC	47.91	-
160	Acetylation	RGDSSSKKDVVELTD CCCCCCCCCEEECCC	58.67	22902405
160	Succinylation	RGDSSSKKDVVELTD CCCCCCCCCEEECCC	58.67	26843850
366	Acetylation	MAAINARKMKFALLK HHHHHHHHHCEEHHH	43.99	22902405
368	Acetylation	AINARKMKFALLKGS HHHHHHHCEEHHHCC	30.44	72607267
375	Phosphorylation	KFALLKGSFSEQGIN CEEHHHCCCCHHHHH	24.82	27097102
377	Phosphorylation	ALLKGSFSEQGINEF EHHHCCCCHHHHHHH	30.61	27097102
402	Phosphorylation	TAPVGGGSFPNITPR CCCCCCCCCCCCCCC	40.58	27097102
407	Phosphorylation	GGSFPNITPREPWDG CCCCCCCCCCCCCCC	23.96	27097102
428	Phosphorylation	VEDDIDLSDVELDDL CCCCCCHHHCCHHHH	35.54	19700791

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
88	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
375	S	Phosphorylation	Kinase	PRKACA	P00517	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDIA6_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDIA6_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PDIA6_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.