PDIA3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDIA3_RAT
• UniProt AC: P11598
• Protein Name: Protein disulfide-isomerase A3
• Gene Name: Pdia3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 505
• Subcellular Localization: Endoplasmic reticulum . Endoplasmic reticulum lumen. Melanosome .
• Protein Sequence: MRFSCLALLPGVALLLASALLASASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEDEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNVESLVKEYDDNGEGITIFRPLHLANKFEDKIVAYTEKKMTSGKIKKFIQESIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNTKGSNYWRNRVMMVAKTFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKSEPIPETNEGPVKVVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Methylation	APWCGHCKRLAPEYE HHCCCHHHHHHHHHH	44.78	-
75	Acetylation	EAAATRLKGIVPLAK HHHHHHHCCCCEEEE	43.21	22902405
98	Phosphorylation	TCNKYGVSGYPTLKI CCCCCCCCCCCEEEE	28.39	28689409
100	Phosphorylation	NKYGVSGYPTLKIFR CCCCCCCCCEEEEEC	5.87	23984901
102	Phosphorylation	YGVSGYPTLKIFRDG CCCCCCCEEEEECCC	32.00	23984901
126	Phosphorylation	RTADGIVSHLKKQAG CCCHHHHHHHHHHCC	22.60	25575281
129	Acetylation	DGIVSHLKKQAGPAS HHHHHHHHHHCCCCC	37.10	22902405
129	Succinylation	DGIVSHLKKQAGPAS HHHHHHHHHHCCCCC	37.10	-
129	Succinylation	DGIVSHLKKQAGPAS HHHHHHHHHHCCCCC	37.10	-
146	Acetylation	LRTEDEFKKFISDKD CCCHHHHHHHCCCCC	44.73	22902405
150	Phosphorylation	DEFKKFISDKDASVV HHHHHHCCCCCCHHH	41.56	16375900
152	Acetylation	FKKFISDKDASVVGF HHHHCCCCCCHHHHH	48.69	22902405
155	Phosphorylation	FISDKDASVVGFFRD HCCCCCCHHHHHHHH	27.71	23984901
165	Phosphorylation	GFFRDLFSDGHSEFL HHHHHHHCCCHHHHH	50.40	30181290
169	Phosphorylation	DLFSDGHSEFLKAAS HHHCCCHHHHHHHHH	35.26	30181290
173	Acetylation	DGHSEFLKAASNLRD CCHHHHHHHHHCCHH	47.42	22902405
191	Phosphorylation	FAHTNVESLVKEYDD CCCCCHHHHHHEECC	33.89	23984901
214	Acetylation	RPLHLANKFEDKIVA EEHHHHHHCCCCCCE	44.52	22902405
218	Succinylation	LANKFEDKIVAYTEK HHHHCCCCCCEEECC	31.70	-
218	Succinylation	LANKFEDKIVAYTEK HHHHCCCCCCEEECC	31.70	-
218	Acetylation	LANKFEDKIVAYTEK HHHHCCCCCCEEECC	31.70	22902405
225	Acetylation	KIVAYTEKKMTSGKI CCCEEECCCCCCCHH	39.79	22902405
252	Acetylation	PHMTEDNKDLIQGKD CCCCCCCCHHHCCHH	67.25	-
276	Phosphorylation	YEKNTKGSNYWRNRV CCCCCCCCCHHHHHH	28.44	23984901
296	Acetylation	TFLDAGHKLNFAVAS HHHHHHHHHHEEHHC	44.18	25786129
306	Phosphorylation	FAVASRKTFSHELSD EEHHCCCCCCCHHHH	29.29	23984901
308	Phosphorylation	VASRKTFSHELSDFG HHCCCCCCCHHHHCC	22.68	23984901
312	Phosphorylation	KTFSHELSDFGLEST CCCCCHHHHCCCCCC	28.10	23984901
318	Phosphorylation	LSDFGLESTTGEIPV HHHCCCCCCCCCCCE	35.99	23984901
319	Phosphorylation	SDFGLESTTGEIPVV HHCCCCCCCCCCCEE	29.46	23984901
320	Phosphorylation	DFGLESTTGEIPVVA HCCCCCCCCCCCEEE	41.94	23984901
329	Methylation	EIPVVAIRTAKGEKF CCCEEEEEECCCCEE	20.92	-
329	Dimethylation	EIPVVAIRTAKGEKF CCCEEEEEECCCCEE	20.92	-
332	Acetylation	VVAIRTAKGEKFVMQ EEEEEECCCCEEEEE	67.97	22902405
335	Acetylation	IRTAKGEKFVMQEEF EEECCCCEEEEEEHH	52.51	22902405
343	Phosphorylation	FVMQEEFSRDGKALE EEEEEHHCCCHHHHH	32.51	12872233
362	Acetylation	EYFDGNLKRYLKSEP HHHCCCHHHHHHCCC	42.89	22902405
363	Dimethylation	YFDGNLKRYLKSEPI HHCCCHHHHHHCCCC	45.22	-
363	Methylation	YFDGNLKRYLKSEPI HHCCCHHHHHHCCCC	45.22	-
366	Acetylation	GNLKRYLKSEPIPET CCHHHHHHCCCCCCC	43.78	22902405
367	Phosphorylation	NLKRYLKSEPIPETN CHHHHHHCCCCCCCC	46.11	23984901
415	Acetylation	HCKNLEPKYKELGEK CCCCCCHHHHHHHHH	60.63	22902405
417	Succinylation	KNLEPKYKELGEKLS CCCCHHHHHHHHHHC	53.22	26843850
417	Acetylation	KNLEPKYKELGEKLS CCCCHHHHHHHHHHC	53.22	22902405
422	Acetylation	KYKELGEKLSKDPNI HHHHHHHHHCCCCCE	57.15	22902405
425	Acetylation	ELGEKLSKDPNIVIA HHHHHHCCCCCEEEE	83.84	22902405
433	Acetylation	DPNIVIAKMDATAND CCCEEEEEEECCCCC	26.62	22902405
443	Phosphorylation	ATANDVPSPYEVKGF CCCCCCCCCCEECCC	39.71	23984901
445	Phosphorylation	ANDVPSPYEVKGFPT CCCCCCCCEECCCCE	37.38	23984901
448	Acetylation	VPSPYEVKGFPTIYF CCCCCEECCCCEEEE	42.78	22902405
454	Phosphorylation	VKGFPTIYFSPANKK ECCCCEEEECCCCCC	10.65	8631326
456	Phosphorylation	GFPTIYFSPANKKLT CCCEEEECCCCCCCC	13.21	-
460	Acetylation	IYFSPANKKLTPKKY EEECCCCCCCCCCCC	51.79	22902405
467	Phosphorylation	KKLTPKKYEGGRELN CCCCCCCCCCCHHHH	26.40	8631326
479	Phosphorylation	ELNDFISYLQREATN HHHHHHHHHHHHCCC	11.31	28689409
494	Acetylation	PPIIQEEKPKKKKKA CCCCCCCCCHHHHHH	62.48	22902405
494	Succinylation	PPIIQEEKPKKKKKA CCCCCCCCCHHHHHH	62.48	26843850

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
445	Y	Phosphorylation	Kinase	LYN	Q07014	PSP
454	Y	Phosphorylation	Kinase	LYN	Q07014	PSP
456	S	Phosphorylation	Kinase	CDK1	P06493	PSP
467	Y	Phosphorylation	Kinase	LYN	Q07014	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDIA3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDIA3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PDIA3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.