PDIA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDIA2_MOUSE
• UniProt AC: D3Z6P0
• Protein Name: Protein disulfide-isomerase A2 {ECO:0000250|UniProtKB:Q13087}
• Gene Name: Pdia2 {ECO:0000312|Ensembl:ENSMUSP00000035584, ECO:0000312|MGI:MGI:1916441}
• Organism: Mus musculus (Mouse).
• Sequence Length: 527
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity)..
• Protein Sequence: MDKQLLPVLLLLLGVSGSWGQGEEPGGPSEVLPEEPTGEEVPKEDGILVLNHRTLSLALQEHSALMVEFYAPWCGHCKELAPEYSKAAALLAAESAVVTLAKVDGPAEPELTKEFEVVGYPTLKFFQNGNRTNPEEYAGPKTAEGIAEWLRRRVGPSATHLEDEEGVQALMAKWDMVVIGFFQDLQGKDMATFLALAKDALDMTFGFTDQPQLFEKFGLTKDTVVLFKKFDEGRADFPVDKETGLDLGDLSRFLVIHSMHLVTEFNSQTSPKIFAAKILNHLLLFVNQTLAQHRELLTDFREAAPPFRGQVLFVMVDVAADNSHVLNYFGLKAEEAPTLRLINVETTKKYAPTGVIAITAASVAAFCQAVLHGEIKHYLLSQEIPPDWDQGPVKTLVSKNFEQVAFDETKNVFVKFYAPWCSHCKEMAPAWEALAEKYKDREDIVIAELDATANELEAFSVLGYPTLKFFPAGPDRKVIDYKSTRDLETFSKFLDSGGHLPKEEPKEPAASAPEAQANSTLGPKEEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
113	Ubiquitination	PAEPELTKEFEVVGY CCCCCCCEEEEEECC	73.38	22790023
130	N-linked_Glycosylation	LKFFQNGNRTNPEEY EEECCCCCCCCHHHH	55.97	-
229	Acetylation	DTVVLFKKFDEGRAD CEEEEEEECCCCCCC	51.19	22826441
269	Phosphorylation	VTEFNSQTSPKIFAA HHHCCCCCCCHHHHH	46.98	27149854
270	Phosphorylation	TEFNSQTSPKIFAAK HHCCCCCCCHHHHHH	19.29	27149854
287	N-linked_Glycosylation	NHLLLFVNQTLAQHR HHHHHHHHHHHHHHH	23.06	-
518	N-linked_Glycosylation	SAPEAQANSTLGPKE CCCHHHHCCCCCCCC	24.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDIA2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDIA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDIA2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SODC_MOUSE	Sod1	physical	16847061

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.