PDE6B_HUMAN - dbPTM
PDE6B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDE6B_HUMAN
UniProt AC P35913
Protein Name Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Gene Name PDE6B
Organism Homo sapiens (Human).
Sequence Length 854
Subcellular Localization Membrane
Lipid-anchor.
Protein Description This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme..
Protein Sequence MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYVLHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSLSEEQAR
------CCCCHHHHH
40.37-
93PhosphorylationLLQADRCSLFMYRQR
HHHHHCCHHHHHHHH
26.0727251275
172PhosphorylationDELTDYKTKNMLATP
HHHCCCCCCCCCCCC
22.7926074081
178PhosphorylationKTKNMLATPIMNGKD
CCCCCCCCCCCCCCH
14.9126074081
212PhosphorylationDEDVFLKYLNFATLY
CHHHHHHHHHHHHHH
14.71-
219PhosphorylationYLNFATLYLKIYHLS
HHHHHHHHHHHHHHH
11.12-
226PhosphorylationYLKIYHLSYLHNCET
HHHHHHHHHHHCCCC
16.61-
227PhosphorylationLKIYHLSYLHNCETR
HHHHHHHHHHCCCCC
20.52-
242PhosphorylationRGQVLLWSANKVFEE
CCEEEEEEHHHHHHH
23.1828509920
400PhosphorylationEEIVGVATFYNRKDG
HHEEEEEEEEECCCC
25.0129083192
469PhosphorylationEIQLILPTRARLGKE
HCEEEECCCHHCCCC
33.25-
546PhosphorylationVLVRFLFSISKGYRR
HHHHHHHHHCCCCEE
28.2630301811
556PhosphorylationKGYRRITYHNWRHGF
CCCEEEEECCCCCCC
7.2618083107
580PhosphorylationLMTGKLKSYYTDLEA
HHHCCCHHHCCHHHH
33.5328857561
592PhosphorylationLEAFAMVTAGLCHDI
HHHHHHHHHHHCCCC
11.2628857561
604PhosphorylationHDIDHRGTNNLYQMK
CCCCCCCCCCCCCCC
22.3828857561
608PhosphorylationHRGTNNLYQMKSQNP
CCCCCCCCCCCCCCH
14.5328857561
681UbiquitinationKKRAMFQKIVDESKN
HHHHHHHHHHHCCCC
33.17-
687UbiquitinationQKIVDESKNYQDKKS
HHHHHCCCCCCCCCH
58.59-
694O-linked_GlycosylationKNYQDKKSWVEYLSL
CCCCCCCHHHHHHCC
41.9430620550
704O-linked_GlycosylationEYLSLETTRKEIVMA
HHHCCHHHHHHHHHH
30.3030620550
715PhosphorylationIVMAMMMTACDLSAI
HHHHHHHHHHCHHHC
13.26-
817UbiquitinationLADEYEAKVKALEEK
HHHHHHHHHHHHHHH
32.12-
834UbiquitinationEERVAAKKVGTEICN
HHHHHHHHHCCCCCC
40.96-
851GeranylgeranylationPAPKSSTCCIL----
CCCCCCCCCCC----
1.15-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDE6B_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDE6B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDE6B_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PDE6B_HUMAN !!

Drug and Disease Associations
Kegg Disease
H00527 Retinitis pigmentosa (RP)
H00787 Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); C
OMIM Disease
613801Retinitis pigmentosa 40 (RP40)
163500Night blindness, congenital stationary, autosomal dominant 2 (CSNBAD2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDE6B_HUMAN

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Related Literatures of Post-Translational Modification

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