UniProt ID | PDE6B_HUMAN | |
---|---|---|
UniProt AC | P35913 | |
Protein Name | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | |
Gene Name | PDE6B | |
Organism | Homo sapiens (Human). | |
Sequence Length | 854 | |
Subcellular Localization |
Membrane Lipid-anchor. |
|
Protein Description | This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.. | |
Protein Sequence | MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYVLHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MSLSEEQAR ------CCCCHHHHH | 40.37 | - | |
93 | Phosphorylation | LLQADRCSLFMYRQR HHHHHCCHHHHHHHH | 26.07 | 27251275 | |
172 | Phosphorylation | DELTDYKTKNMLATP HHHCCCCCCCCCCCC | 22.79 | 26074081 | |
178 | Phosphorylation | KTKNMLATPIMNGKD CCCCCCCCCCCCCCH | 14.91 | 26074081 | |
212 | Phosphorylation | DEDVFLKYLNFATLY CHHHHHHHHHHHHHH | 14.71 | - | |
219 | Phosphorylation | YLNFATLYLKIYHLS HHHHHHHHHHHHHHH | 11.12 | - | |
226 | Phosphorylation | YLKIYHLSYLHNCET HHHHHHHHHHHCCCC | 16.61 | - | |
227 | Phosphorylation | LKIYHLSYLHNCETR HHHHHHHHHHCCCCC | 20.52 | - | |
242 | Phosphorylation | RGQVLLWSANKVFEE CCEEEEEEHHHHHHH | 23.18 | 28509920 | |
400 | Phosphorylation | EEIVGVATFYNRKDG HHEEEEEEEEECCCC | 25.01 | 29083192 | |
469 | Phosphorylation | EIQLILPTRARLGKE HCEEEECCCHHCCCC | 33.25 | - | |
546 | Phosphorylation | VLVRFLFSISKGYRR HHHHHHHHHCCCCEE | 28.26 | 30301811 | |
556 | Phosphorylation | KGYRRITYHNWRHGF CCCEEEEECCCCCCC | 7.26 | 18083107 | |
580 | Phosphorylation | LMTGKLKSYYTDLEA HHHCCCHHHCCHHHH | 33.53 | 28857561 | |
592 | Phosphorylation | LEAFAMVTAGLCHDI HHHHHHHHHHHCCCC | 11.26 | 28857561 | |
604 | Phosphorylation | HDIDHRGTNNLYQMK CCCCCCCCCCCCCCC | 22.38 | 28857561 | |
608 | Phosphorylation | HRGTNNLYQMKSQNP CCCCCCCCCCCCCCH | 14.53 | 28857561 | |
681 | Ubiquitination | KKRAMFQKIVDESKN HHHHHHHHHHHCCCC | 33.17 | - | |
687 | Ubiquitination | QKIVDESKNYQDKKS HHHHHCCCCCCCCCH | 58.59 | - | |
694 | O-linked_Glycosylation | KNYQDKKSWVEYLSL CCCCCCCHHHHHHCC | 41.94 | 30620550 | |
704 | O-linked_Glycosylation | EYLSLETTRKEIVMA HHHCCHHHHHHHHHH | 30.30 | 30620550 | |
715 | Phosphorylation | IVMAMMMTACDLSAI HHHHHHHHHHCHHHC | 13.26 | - | |
817 | Ubiquitination | LADEYEAKVKALEEK HHHHHHHHHHHHHHH | 32.12 | - | |
834 | Ubiquitination | EERVAAKKVGTEICN HHHHHHHHHCCCCCC | 40.96 | - | |
851 | Geranylgeranylation | PAPKSSTCCIL---- CCCCCCCCCCC---- | 1.15 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PDE6B_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PDE6B_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PDE6B_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of PDE6B_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
H00527 | Retinitis pigmentosa (RP) | |||||
H00787 | Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); C | |||||
OMIM Disease | ||||||
613801 | Retinitis pigmentosa 40 (RP40) | |||||
163500 | Night blindness, congenital stationary, autosomal dominant 2 (CSNBAD2) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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