PDE4A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDE4A_MOUSE
• UniProt AC: O89084
• Protein Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4A
• Gene Name: Pde4a
• Organism: Mus musculus (Mouse).
• Sequence Length: 844
• Subcellular Localization: Cytoplasm, perinuclear region.
• Protein Description: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes..
• Protein Sequence: MEPPAAPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERSEPERSPHRPIERADAVDTGDRPGLRTTRMSWPSSFHGTGTGGGSSRRLEAENGPTPSPGRSPLDSQASPGLMLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVASEAHGEDLIVTPFAQVLASLRNVRSNFSLLTNVPIPSNKRSPLGGPPSVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTPRQRPFQQPPPAAVQQAQPMSQITGLKKLVHTGSLNINVPRFGVKTDQEDLLAQELENLSKWGLNIFCVSEYAGGRSLSCIMYTIFQERDLLKKFHIPVDTMMTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNRDWYHSAIRQSPSPTLEEEPGVLSDPALPDKFQFELTLEEEDEEDSLEVPGLPCTEETLLAPHDTRAQAMEQSKVKGQSPAVVEVAESLKQETASAHGAPEESAEAVGHSFSLETSILPDLRTLSPSEEAQGLLGLPSMAAEVEAPRDHLAAMRACSACSGTSGDNSAVISAPGRWGSGGDPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	PAAPSERSLSLSLPG CCCCCCCCCCCCCCC	20.47	22942356
13	Phosphorylation	APSERSLSLSLPGPR CCCCCCCCCCCCCCC	19.70	26824392
15	Phosphorylation	SERSLSLSLPGPREG CCCCCCCCCCCCCCC	29.19	29899451
29 (in isoform 3)	Phosphorylation	-	39.33	28464351
45 (in isoform 3)	Phosphorylation	-	38.09	28464351
48	Phosphorylation	IRIQQRGYSDSAERS CEEEECCCCCCCCCC	16.11	29899451
49	Phosphorylation	RIQQRGYSDSAERSE EEEECCCCCCCCCCC	28.10	29899451
51	Phosphorylation	QQRGYSDSAERSEPE EECCCCCCCCCCCCC	26.53	29899451
60	Phosphorylation	ERSEPERSPHRPIER CCCCCCCCCCCCCCH	24.32	26824392
85	Phosphorylation	GLRTTRMSWPSSFHG CCCCCCCCCCCCCCC	32.32	21183079
99	Phosphorylation	GTGTGGGSSRRLEAE CCCCCCCCCCCEECC	24.77	21183079
116	Phosphorylation	PTPSPGRSPLDSQAS CCCCCCCCCCCCCCC	35.41	25777480
120	Phosphorylation	PGRSPLDSQASPGLM CCCCCCCCCCCCCCE	35.02	25777480
123	Phosphorylation	SPLDSQASPGLMLHA CCCCCCCCCCCEEEC	16.32	25777480
134	Phosphorylation	MLHAGAATSQRRESF EEECCCCCCHHHHHH	25.51	25777480
135	Phosphorylation	LHAGAATSQRRESFL EECCCCCCHHHHHHH	19.57	25777480
140	Phosphorylation	ATSQRRESFLYRSDS CCCHHHHHHHCCCCC	20.81	27742792
143	Phosphorylation	QRRESFLYRSDSDYD HHHHHHHCCCCCCCC	13.17	22324799
145	Phosphorylation	RESFLYRSDSDYDMS HHHHHCCCCCCCCCC	28.10	29899451
147	Phosphorylation	SFLYRSDSDYDMSPK HHHCCCCCCCCCCCC	39.04	25521595
149	Phosphorylation	LYRSDSDYDMSPKTM HCCCCCCCCCCCCCC	19.93	22324799
152	Phosphorylation	SDSDYDMSPKTMSRN CCCCCCCCCCCCCCC	21.98	25521595
155	Phosphorylation	DYDMSPKTMSRNSSV CCCCCCCCCCCCCCH	24.62	29899451
160	Phosphorylation	PKTMSRNSSVASEAH CCCCCCCCCHHHHHC	25.69	29899451
161	Phosphorylation	KTMSRNSSVASEAHG CCCCCCCCHHHHHCC	25.83	29899451
164	Phosphorylation	SRNSSVASEAHGEDL CCCCCHHHHHCCCCE	32.91	22817900
188	Phosphorylation	ASLRNVRSNFSLLTN HHHCCHHHCCHHCCC	37.63	26239621
200	Phosphorylation	LTNVPIPSNKRSPLG CCCCCCCCCCCCCCC	56.56	26239621
204	Phosphorylation	PIPSNKRSPLGGPPS CCCCCCCCCCCCCCC	26.53	26824392
211	Phosphorylation	SPLGGPPSVCKATLS CCCCCCCCHHHHHCC	43.19	26643407
266	Phosphorylation	RMLNRELTHLSEMSR HHHHHHHHHHHHHHC	18.93	25162660
274	Phosphorylation	HLSEMSRSGNQVSEY HHHHHHCCCCHHHHH	34.49	22817900
279	Phosphorylation	SRSGNQVSEYISNTF HCCCCHHHHHHHHHH	18.21	29899451
281	Phosphorylation	SGNQVSEYISNTFLD CCCHHHHHHHHHHHC	11.35	20415495
283	Phosphorylation	NQVSEYISNTFLDKQ CHHHHHHHHHHHCCC	28.99	20415495
285	Phosphorylation	VSEYISNTFLDKQHE HHHHHHHHHHCCCCC	20.84	20415495
297	Phosphorylation	QHEVEIPSPTPRQRP CCCCCCCCCCCCCCC	47.25	22324799
299	Phosphorylation	EVEIPSPTPRQRPFQ CCCCCCCCCCCCCCC	35.13	22324799
331	Phosphorylation	GLKKLVHTGSLNINV CCHHHHHCCCCEECC	22.46	22324799
333	Phosphorylation	KKLVHTGSLNINVPR HHHHHCCCCEECCCC	21.28	25521595
537	Phosphorylation	TDMSKHMTLLADLKT CCHHHHHHHHHHHHH	20.52	-
552	Phosphorylation	MVETKKVTSSGVLLL HHHCCCCCCCCEEEE	26.51	25521595
553	Phosphorylation	VETKKVTSSGVLLLD HHCCCCCCCCEEEEC	28.25	25521595
554	Phosphorylation	ETKKVTSSGVLLLDN HCCCCCCCCEEEECC	24.45	25521595
562	Phosphorylation	GVLLLDNYSDRIQVL CEEEECCHHHHHHHH	16.18	20415495
563	Phosphorylation	VLLLDNYSDRIQVLR EEEECCHHHHHHHHH	27.02	20415495
614	Phosphorylation	RERGMEISPMCDKHT HHHCCCCCCCCCCCC	8.02	25521595
672	Phosphorylation	YHSAIRQSPSPTLEE HHHHHHCCCCCCCCC	19.93	23737553
674	Phosphorylation	SAIRQSPSPTLEEEP HHHHCCCCCCCCCCC	35.45	23737553
676	Phosphorylation	IRQSPSPTLEEEPGV HHCCCCCCCCCCCCC	51.65	23737553
784	Phosphorylation	SILPDLRTLSPSEEA CCCCCCCCCCCCHHH	38.59	25293948
786	Phosphorylation	LPDLRTLSPSEEAQG CCCCCCCCCCHHHHH	26.26	26824392
788	Phosphorylation	DLRTLSPSEEAQGLL CCCCCCCCHHHHHHH	44.70	22942356
799	Phosphorylation	QGLLGLPSMAAEVEA HHHHCCHHHHHHCCC	26.54	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDE4A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDE4A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDE4A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PDE4A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.