PDE12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDE12_MOUSE
• UniProt AC: Q3TIU4
• Protein Name: 2',5'-phosphodiesterase 12
• Gene Name: Pde12
• Organism: Mus musculus (Mouse).
• Sequence Length: 608
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferon (IFNs) (By similarity)..
• Protein Sequence: MWRLPGRSALRGVRSVVERRSRAEAGTHEAVRAMERAVVRCVPSEPKLSLSFALADGSHKNMQRDQSEPLGRALSRIATNALKGHAKVAAAKKSRKNRAHSSGGAACEATGPEPVATCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPTFTELQLPRYIMAGFPVCPKLGVEFGDPASSVFRWYKEVKPGAAEPGDSGPASSSHSSQPSAWIETGVDERVYTPCNADIGLRLRLHCTPGNGQRFGPSRELESLCPVEAGPGTCTFDHRHLYTKKVTEDSFIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADLICLQEVDRAVFSDSLVPALEAFGLEGVFRIKQHEGLATFYRKSKFRLLSQHDISFQEALKSDPLHKELLEKLALNPLAQEKVLQRSSVLQISVLQSTTDSSKKICVANTHLYWHPKGGYIRLIQMEVALVHIRHVSRDLYPGIPVIFCGDFNSTPSTGMYHFVISGSIAEDHEDWASNGEEERCSMPLSHCFKLKSACGEPAYTNYVGGFHGCLDYIFIDLNTLEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Phosphorylation	EPLGRALSRIATNAL CHHHHHHHHHHHHHH	22.21	22817900
101	Phosphorylation	SRKNRAHSSGGAACE HHHCCCCCCCCCCCC	29.69	25266776
102	Phosphorylation	RKNRAHSSGGAACEA HHCCCCCCCCCCCCC	31.23	25266776
110	Phosphorylation	GGAACEATGPEPVAT CCCCCCCCCCCCCCC	30.86	25266776
216	Phosphorylation	DSGPASSSHSSQPSA CCCCCCCCCCCCCCC	25.54	-
237	Glutathionylation	DERVYTPCNADIGLR CCCEECCCCCCCCEE	5.17	24333276
289	Phosphorylation	HLYTKKVTEDSFIRT CEECCCCCCCCCCCC	42.84	28285833
292	Phosphorylation	TKKVTEDSFIRTVSY CCCCCCCCCCCCEEH	19.15	28285833
426	Ubiquitination	LNPLAQEKVLQRSSV CCHHHHHHHHHHCCE	35.84	22790023
426	Acetylation	LNPLAQEKVLQRSSV CCHHHHHHHHHHCCE	35.84	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDE12_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDE12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDE12_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PDE12_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.