| UniProt ID | PDE10_MOUSE | |
|---|---|---|
| UniProt AC | Q8CA95 | |
| Protein Name | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | |
| Gene Name | Pde10a | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 790 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.. | |
| Protein Sequence | MSNDSTEGTVGSCNATGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKTNKAKDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFLGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPIFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGPAPSKSTPEKLNVKVED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 (in isoform 3) | Phosphorylation | - | 55.29 | 20415495 | |
| 28 (in isoform 3) | Ubiquitination | - | 16.38 | - | |
| 63 | Phosphorylation | NKAKDEPSPKEVSRY CCCCCCCCHHHHHHH | 46.70 | 29899451 | |
| 301 | Ubiquitination | FQVDHKNKELYSDLF EEECCCCHHHHHHHC | 54.63 | 22790023 | |
| 301 (in isoform 3) | Ubiquitination | - | 54.63 | 22790023 | |
| 304 | Phosphorylation | DHKNKELYSDLFDIG CCCCHHHHHHHCCCC | 10.96 | - | |
| 307 (in isoform 3) | Ubiquitination | - | 3.23 | - | |
| 329 | Phosphorylation | KTKEIRFSIEKGIAG CCCEEEEEECCCCCC | 21.71 | - | |
| 332 | Ubiquitination | EIRFSIEKGIAGQVA EEEEEECCCCCCEEE | 54.68 | 22790023 | |
| 332 (in isoform 3) | Ubiquitination | - | 54.68 | 22790023 | |
| 338 (in isoform 3) | Ubiquitination | - | 3.68 | - | |
| 770 | Phosphorylation | EETAMWISGPGPAPS CCEEEEEECCCCCCC | 24.34 | 20415495 | |
| 777 | Phosphorylation | SGPGPAPSKSTPEKL ECCCCCCCCCCCCCC | 41.15 | 19060867 | |
| 779 | Phosphorylation | PGPAPSKSTPEKLNV CCCCCCCCCCCCCCC | 54.23 | 19060867 | |
| 780 | Phosphorylation | GPAPSKSTPEKLNVK CCCCCCCCCCCCCCC | 38.92 | 21183079 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PDE10_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PDE10_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PDE10_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PDE10_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
