| UniProt ID | PCSK7_HUMAN | |
|---|---|---|
| UniProt AC | Q16549 | |
| Protein Name | Proprotein convertase subtilisin/kexin type 7 | |
| Gene Name | PCSK7 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 785 | |
| Subcellular Localization |
Golgi apparatus, trans-Golgi network membrane Single-pass type I membrane protein. Seems to be localized intracellularly to the trans Golgi network.. |
|
| Protein Description | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.. | |
| Protein Sequence | MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 167 | N-linked_Glycosylation | RSPGRDINVTGVWER CCCCCCEEEEEEEEE | 29.59 | UniProtKB CARBOHYD | |
| 175 | N-linked_Glycosylation | VTGVWERNVTGRGVT EEEEEEECCCCCCEE | 24.96 | UniProtKB CARBOHYD | |
| 241 | N-linked_Glycosylation | GEIAAVPNNSFCAVG CEEEECCCCCCEEEH | 50.62 | UniProtKB CARBOHYD | |
| 278 | Phosphorylation | AVAFNKHYQINDIYS HHHCCCCCCCCCEEE | 16.82 | - | |
| 284 | Phosphorylation | HYQINDIYSCSWGPD CCCCCCEEECCCCCC | 13.39 | - | |
| 505 | Phosphorylation | AIPQSPRSLEVLWNV CCCCCCCHHHHHHHH | 32.06 | - | |
| 511 | N-linked_Glycosylation | RSLEVLWNVSRMDLE CHHHHHHHHCHHHHH | 20.09 | UniProtKB CARBOHYD | |
| 524 | Phosphorylation | LEMSGLKTLEHVAVT HHHCCCCEEEEEEEE | 42.28 | - | |
| 531 | Phosphorylation | TLEHVAVTVSITHPR EEEEEEEEEEECCCC | 9.97 | 22210691 | |
| 533 | Phosphorylation | EHVAVTVSITHPRRG EEEEEEEEECCCCCC | 16.65 | 22210691 | |
| 535 | Phosphorylation | VAVTVSITHPRRGSL EEEEEEECCCCCCEE | 20.51 | 22210691 | |
| 541 | Phosphorylation | ITHPRRGSLELKLFC ECCCCCCEEEEEEEC | 19.50 | 18452278 | |
| 579 | S-palmitoylation | WTFSTVRCWGERARG CCEEEEEECCHHCCC | 4.81 | 9341152 | |
| 634 | Phosphorylation | RLLESAMSGKYLHDD HHHHHHHCCCCCCCC | 31.67 | - | |
| 646 | S-palmitoylation | HDDFALPCPPGLKIP CCCCCCCCCCCCCCC | 7.07 | 9341152 | |
| 673 | S-palmitoylation | KTLVLVGCFTVFWTV HHHHHHHHHHHHHHH | 1.69 | 9341152 | |
| 675 | Phosphorylation | LVLVGCFTVFWTVYY HHHHHHHHHHHHHHH | 20.90 | - | |
| 679 | Phosphorylation | GCFTVFWTVYYMLEV HHHHHHHHHHHHHHH | 6.28 | - | |
| 682 | Phosphorylation | TVFWTVYYMLEVYLS HHHHHHHHHHHHHHH | 7.29 | - | |
| 689 | Phosphorylation | YMLEVYLSQRNVASN HHHHHHHHCCCCCCC | 14.92 | - | |
| 699 | S-palmitoylation | NVASNQVCRSGPCHW CCCCCCCHHCCCCCC | 1.75 | 30610172 | |
| 704 | S-palmitoylation | QVCRSGPCHWPHRSR CCHHCCCCCCCCCCC | 6.30 | 30610172 | |
| 729 | Ubiquitination | SVPLCSSKDPDEVET CCCCCCCCCHHHCCC | 57.92 | 29967540 | |
| 764 | Ubiquitination | DWSLSQNKSALDCPH CCCCCCCCCCCCCCC | 29.48 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 505 | S | Phosphorylation | Kinase | FAM20C | Q8IXL6 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCSK7_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCSK7_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PCSK7_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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