UniProt ID | PCKGC_MOUSE | |
---|---|---|
UniProt AC | Q9Z2V4 | |
Protein Name | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | |
Gene Name | Pck1 {ECO:0000312|MGI:MGI:97501} | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 622 | |
Subcellular Localization | Cytoplasm. | |
Protein Description | Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.. | |
Protein Sequence | MPPQLHNGLDFSAKVIQGSLDSLPQAVRKFVEGNAQLCQPEYIHICDGSEEEYGQLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGISVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDAEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPEGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKDGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYIPKENALNLKGLGGVNVEELFGISKEFWEKEVEEIDRYLEDQVNTDLPYEIERELRALKQRISQM | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
19 | Phosphorylation | SAKVIQGSLDSLPQA CHHHHHCCHHHHHHH | 16.78 | 25521595 | |
22 | Phosphorylation | VIQGSLDSLPQAVRK HHHCCHHHHHHHHHH | 47.44 | 23984901 | |
70 | Acetylation | EGVIRKLKKYDNCWL HCHHHHHHHCCCEEE | 52.93 | - | |
71 | Acetylation | GVIRKLKKYDNCWLA CHHHHHHHCCCEEEE | 69.17 | - | |
71 | Ubiquitination | GVIRKLKKYDNCWLA CHHHHHHHCCCEEEE | 69.17 | - | |
75 | S-palmitoylation | KLKKYDNCWLALTDP HHHHCCCEEEEECCH | 2.62 | 28526873 | |
90 | Phosphorylation | RDVARIESKTVIITQ HHHHHCEECEEEEEC | 31.12 | - | |
91 | Ubiquitination | DVARIESKTVIITQE HHHHCEECEEEEECC | 33.74 | 27667366 | |
91 | Acetylation | DVARIESKTVIITQE HHHHCEECEEEEECC | 33.74 | - | |
91 | Malonylation | DVARIESKTVIITQE HHHHCEECEEEEECC | 33.74 | 26320211 | |
92 | Phosphorylation | VARIESKTVIITQEQ HHHCEECEEEEECCC | 26.64 | 21183079 | |
107 | Ubiquitination | RDTVPIPKTGLSQLG CCCCCCCCCCHHHHC | 56.81 | 27667366 | |
118 | Phosphorylation | SQLGRWMSEEDFEKA HHHCCCCCHHHHHHH | 30.76 | 22817900 | |
124 | Ubiquitination | MSEEDFEKAFNARFP CCHHHHHHHHHCCCC | 59.27 | 27667366 | |
124 | Acetylation | MSEEDFEKAFNARFP CCHHHHHHHHHCCCC | 59.27 | 23954790 | |
135 | Ubiquitination | ARFPGCMKGRTMYVI CCCCCCCCCCEEEEE | 49.68 | - | |
198 | S-palmitoylation | KCLHSVGCPLPLKKP HHHHHCCCCCCCCCC | 2.68 | 28526873 | |
203 | Ubiquitination | VGCPLPLKKPLVNNW CCCCCCCCCCCCCCC | 50.86 | - | |
204 | Ubiquitination | GCPLPLKKPLVNNWA CCCCCCCCCCCCCCC | 51.79 | - | |
212 | S-palmitoylation | PLVNNWACNPELTLI CCCCCCCCCCCEEEE | 7.06 | 28526873 | |
239 | Phosphorylation | GSGYGGNSLLGKKCF CCCCCCCHHHHHHHH | 28.39 | - | |
243 | Ubiquitination | GGNSLLGKKCFALRI CCCHHHHHHHHHHHH | 46.46 | - | |
278 | Ubiquitination | TNPEGKKKYLAAAFP CCCCHHHHHHHHHCH | 49.32 | - | |
286 | Phosphorylation | YLAAAFPSACGKTNL HHHHHCHHCCCCCCC | 29.72 | 29472430 | |
288 | S-palmitoylation | AAAFPSACGKTNLAM HHHCHHCCCCCCCCC | 7.24 | 28526873 | |
290 | Ubiquitination | AFPSACGKTNLAMMN HCHHCCCCCCCCCCC | 33.84 | - | |
307 | S-palmitoylation | LPGWKVECVGDDIAW CCCCEEEECCCCEEE | 4.67 | 28526873 | |
316 | Ubiquitination | GDDIAWMKFDAQGNL CCCEEEEEEECCCCE | 29.41 | - | |
342 | Ubiquitination | VAPGTSVKTNPNAIK ECCCCCCCCCCCHHH | 42.21 | 27667366 | |
349 | Ubiquitination | KTNPNAIKTIQKNTI CCCCCHHHHHHCCEE | 36.85 | 27667366 | |
389 | Ubiquitination | TITSWKNKEWRPQDA EEEECCCCCCCCCCC | 55.73 | - | |
407 | S-palmitoylation | AHPNSRFCTPASQCP CCCCCCCCCCHHHCC | 4.30 | 28526873 | |
413 | S-palmitoylation | FCTPASQCPIIDPAW CCCCHHHCCCCCCCC | 2.12 | 28526873 | |
471 | Ubiquitination | ATAAAEHKGKIIMHD HHHHHHHCCEEEEEC | 54.10 | 27667366 | |
473 | Acetylation | AAAEHKGKIIMHDPF HHHHHCCEEEEECHH | 33.59 | - | |
521 | Acetylation | VNWFRKDKDGKFLWP EEEEEECCCCCCCCC | 71.99 | - | |
524 | Acetylation | FRKDKDGKFLWPGFG EEECCCCCCCCCCCC | 47.63 | - | |
524 | Ubiquitination | FRKDKDGKFLWPGFG EEECCCCCCCCCCCC | 47.63 | 27667366 | |
551 | Ubiquitination | IEGEDSAKLTPIGYI CCCCCCCCEEECEEE | 57.77 | 27667366 | |
560 | Ubiquitination | TPIGYIPKENALNLK EECEEECHHHCCCCC | 54.78 | 27667366 | |
567 | Ubiquitination | KENALNLKGLGGVNV HHHCCCCCCCCCCCH | 51.52 | - | |
587 | Ubiquitination | ISKEFWEKEVEEIDR CCHHHHHHHHHHHHH | 58.62 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCKGC_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference |
---|---|---|---|---|
90 | S | Phosphorylation |
| - |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCKGC_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of PCKGC_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...