PCKGC_MOUSE - dbPTM
PCKGC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCKGC_MOUSE
UniProt AC Q9Z2V4
Protein Name Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Gene Name Pck1 {ECO:0000312|MGI:MGI:97501}
Organism Mus musculus (Mouse).
Sequence Length 622
Subcellular Localization Cytoplasm.
Protein Description Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle..
Protein Sequence MPPQLHNGLDFSAKVIQGSLDSLPQAVRKFVEGNAQLCQPEYIHICDGSEEEYGQLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGISVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDAEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPEGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKDGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYIPKENALNLKGLGGVNVEELFGISKEFWEKEVEEIDRYLEDQVNTDLPYEIERELRALKQRISQM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationSAKVIQGSLDSLPQA
CHHHHHCCHHHHHHH
16.7825521595
22PhosphorylationVIQGSLDSLPQAVRK
HHHCCHHHHHHHHHH
47.4423984901
70AcetylationEGVIRKLKKYDNCWL
HCHHHHHHHCCCEEE
52.93-
71AcetylationGVIRKLKKYDNCWLA
CHHHHHHHCCCEEEE
69.17-
71UbiquitinationGVIRKLKKYDNCWLA
CHHHHHHHCCCEEEE
69.17-
75S-palmitoylationKLKKYDNCWLALTDP
HHHHCCCEEEEECCH
2.6228526873
90PhosphorylationRDVARIESKTVIITQ
HHHHHCEECEEEEEC
31.12-
91UbiquitinationDVARIESKTVIITQE
HHHHCEECEEEEECC
33.7427667366
91AcetylationDVARIESKTVIITQE
HHHHCEECEEEEECC
33.74-
91MalonylationDVARIESKTVIITQE
HHHHCEECEEEEECC
33.7426320211
92PhosphorylationVARIESKTVIITQEQ
HHHCEECEEEEECCC
26.6421183079
107UbiquitinationRDTVPIPKTGLSQLG
CCCCCCCCCCHHHHC
56.8127667366
118PhosphorylationSQLGRWMSEEDFEKA
HHHCCCCCHHHHHHH
30.7622817900
124UbiquitinationMSEEDFEKAFNARFP
CCHHHHHHHHHCCCC
59.2727667366
124AcetylationMSEEDFEKAFNARFP
CCHHHHHHHHHCCCC
59.2723954790
135UbiquitinationARFPGCMKGRTMYVI
CCCCCCCCCCEEEEE
49.68-
198S-palmitoylationKCLHSVGCPLPLKKP
HHHHHCCCCCCCCCC
2.6828526873
203UbiquitinationVGCPLPLKKPLVNNW
CCCCCCCCCCCCCCC
50.86-
204UbiquitinationGCPLPLKKPLVNNWA
CCCCCCCCCCCCCCC
51.79-
212S-palmitoylationPLVNNWACNPELTLI
CCCCCCCCCCCEEEE
7.0628526873
239PhosphorylationGSGYGGNSLLGKKCF
CCCCCCCHHHHHHHH
28.39-
243UbiquitinationGGNSLLGKKCFALRI
CCCHHHHHHHHHHHH
46.46-
278UbiquitinationTNPEGKKKYLAAAFP
CCCCHHHHHHHHHCH
49.32-
286PhosphorylationYLAAAFPSACGKTNL
HHHHHCHHCCCCCCC
29.7229472430
288S-palmitoylationAAAFPSACGKTNLAM
HHHCHHCCCCCCCCC
7.2428526873
290UbiquitinationAFPSACGKTNLAMMN
HCHHCCCCCCCCCCC
33.84-
307S-palmitoylationLPGWKVECVGDDIAW
CCCCEEEECCCCEEE
4.6728526873
316UbiquitinationGDDIAWMKFDAQGNL
CCCEEEEEEECCCCE
29.41-
342UbiquitinationVAPGTSVKTNPNAIK
ECCCCCCCCCCCHHH
42.2127667366
349UbiquitinationKTNPNAIKTIQKNTI
CCCCCHHHHHHCCEE
36.8527667366
389UbiquitinationTITSWKNKEWRPQDA
EEEECCCCCCCCCCC
55.73-
407S-palmitoylationAHPNSRFCTPASQCP
CCCCCCCCCCHHHCC
4.3028526873
413S-palmitoylationFCTPASQCPIIDPAW
CCCCHHHCCCCCCCC
2.1228526873
471UbiquitinationATAAAEHKGKIIMHD
HHHHHHHCCEEEEEC
54.1027667366
473AcetylationAAAEHKGKIIMHDPF
HHHHHCCEEEEECHH
33.59-
521AcetylationVNWFRKDKDGKFLWP
EEEEEECCCCCCCCC
71.99-
524AcetylationFRKDKDGKFLWPGFG
EEECCCCCCCCCCCC
47.63-
524UbiquitinationFRKDKDGKFLWPGFG
EEECCCCCCCCCCCC
47.6327667366
551UbiquitinationIEGEDSAKLTPIGYI
CCCCCCCCEEECEEE
57.7727667366
560UbiquitinationTPIGYIPKENALNLK
EECEEECHHHCCCCC
54.7827667366
567UbiquitinationKENALNLKGLGGVNV
HHHCCCCCCCCCCCH
51.52-
587UbiquitinationISKEFWEKEVEEIDR
CCHHHHHHHHHHHHH
58.62-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCKGC_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
90SPhosphorylation

-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCKGC_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PCKGC_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCKGC_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP