PCDH8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDH8_MOUSE
• UniProt AC: Q7TSK3
• Protein Name: Protocadherin-8
• Gene Name: Pcdh8
• Organism: Mus musculus (Mouse).
• Sequence Length: 1070
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane. Expressed in neuronal cell bodies and dendrites. Localized to excita
• Protein Description: Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway (By similarity). In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis..
• Protein Sequence: MSPAKRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGPSPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQASYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFTFGARTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGPGPRTATCKVIVRIRDVNDNAPEISITPLAAPGAPATSPFAAAAAAAALGGADAASSTGSGTQEAGITSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGTPPLRTVRPYTVRVGDENDNAPIFTKPVYEVSVRENNPPGAYLATVAARDPDVGRNGQVTYRLVEAEVGRSGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQASDGGSPQLSSNALVQVRVLDQNDHSPILVHPAPANGSLEVAVPGRSTKDTAVARIQARDADEGANGELAFDLLQQEPREAFSIGRHTGEIMLTGDLSQEPPGRVFKALLVISDGGRPPLTTTATVSFVVTAGGGSAVPASSGSPEHSRPPGSRLAPSGPSLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPDETARGTGPRPNMFDVLTFPGSGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCAGPNVHPPPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYESPPGSRYVSPKKGINENV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
616	N-linked_Glycosylation	LVHPAPANGSLEVAV EEEECCCCCCEEEEE	39.26	-
798	Phosphorylation	GAAGGGASAPGSPDE CCCCCCCCCCCCCCC	37.97	25521595
802	Phosphorylation	GGASAPGSPDETARG CCCCCCCCCCCCCCC	28.28	25521595
902	Phosphorylation	WKGHSFNTISGREAE EECCCCCCCCCCCCH	17.95	28576409
921	Phosphorylation	KDSGKGDSDFNDSDS CCCCCCCCCCCCCCC	53.41	29899451
926	Phosphorylation	GDSDFNDSDSDISGD CCCCCCCCCCCCCHH	39.87	25521595
928	Phosphorylation	SDFNDSDSDISGDAL CCCCCCCCCCCHHHH	40.57	29899451
960	Phosphorylation	ECKILGHSDRCWSPS ECEECCCCCCCCCCC	25.59	28418008
1028	Phosphorylation	LHRDYDRTVTLLSPP HCCCCCCEEEEECCC	18.23	-
1033	Phosphorylation	DRTVTLLSPPRPGRL CCEEEEECCCCCCCC	35.65	-
1051	Phosphorylation	QEIGVPLYESPPGSR HHCCCCCCCCCCCCC	14.32	29899451
1053	Phosphorylation	IGVPLYESPPGSRYV CCCCCCCCCCCCCCC	23.88	30372032
1057	Phosphorylation	LYESPPGSRYVSPKK CCCCCCCCCCCCCCC	26.64	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDH8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDH8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDH8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PCDH8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.