PCDH8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDH8_HUMAN
• UniProt AC: O95206
• Protein Name: Protocadherin-8
• Gene Name: PCDH8
• Organism: Homo sapiens (Human).
• Sequence Length: 1070
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane. Also expressed in neuronal cell bodies. Localized to excitatory, but
• Protein Description: Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity)..
• Protein Sequence: MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPVRRWGS ------CCCCCCCCC	43.33	22210691
31	Phosphorylation	LSVAQSKTVRYSTFE HHHHCCCCCEECCCC	18.57	22210691
70	N-linked_Glycosylation	FRLMKQFNSSLLRVR HHHHHHHCCCCEEEE	28.35	UniProtKB CARBOHYD
72	Phosphorylation	LMKQFNSSLLRVREG HHHHHCCCCEEEECC	32.31	24719451
226	Phosphorylation	DGGRPPRSATAALSV CCCCCCCCCEEEEEE	35.43	23403867
228	Phosphorylation	GRPPRSATAALSVRV CCCCCCCEEEEEEEE	17.45	23403867
232	Phosphorylation	RSATAALSVRVLDAN CCCEEEEEEEEEECC	11.80	23403867
399	Phosphorylation	TPEAGATSLVPEGAA CCCCCCCCCCCCCHH	27.17	28787133
464	N-linked_Glycosylation	RERIAEYNLTLVAED HHHHHHCCEEEEECC	20.32	UniProtKB CARBOHYD
582	Phosphorylation	LDVRIQASDGGSPQL CEEEEEECCCCCCCC	22.03	18767875
592	Phosphorylation	GSPQLSSSALVQVRV CCCCCCCCCEEEEEE	23.42	18767875
616	N-linked_Glycosylation	LVHPAPANGSLEVAV EEEECCCCCCEEEEE	39.26	UniProtKB CARBOHYD
693	Phosphorylation	FRALLVISDGGRPPL EEEEEEEECCCCCCC	23.79	-
701	Phosphorylation	DGGRPPLTTTATVSF CCCCCCCCEEEEEEE	28.07	-
702	Phosphorylation	GGRPPLTTTATVSFV CCCCCCCEEEEEEEE	23.32	-
705	Phosphorylation	PPLTTTATVSFVVTA CCCCEEEEEEEEEEC	18.00	-
804	Phosphorylation	GGASAPGSPEEAARG CCCCCCCCHHHHHCC	28.25	27732954
879	Phosphorylation	RGAHAEPYGASPGFG CCCCCCCCCCCCCCC	19.48	25884760
917	Phosphorylation	EKFSGKDSGKGDSDF HHHCCCCCCCCCCCC	45.98	27732954
922	Phosphorylation	KDSGKGDSDFNDSDS CCCCCCCCCCCCCCC	53.41	27732954
927	Phosphorylation	GDSDFNDSDSDISGD CCCCCCCCCCCCCHH	39.87	27732954
929	Phosphorylation	SDFNDSDSDISGDAL CCCCCCCCCCCHHHH	40.57	27732954
961	Phosphorylation	ECKILGHSDRCWSPS ECEECCCCCCCCCCC	25.59	29449344
1003	Phosphorylation	DPLRRDNYYQAQLPK CCCCCCCCCCCCCCC	10.97	-
1004	Phosphorylation	PLRRDNYYQAQLPKT CCCCCCCCCCCCCCC	12.02	25884760
1018	Phosphorylation	TVGLQSVYEKVLHRD CCCCHHHHHHHHCCC	18.45	24173317
1026	Phosphorylation	EKVLHRDYDRTVTLL HHHHCCCCCCEEEEE	13.79	22817900
1034	Phosphorylation	DRTVTLLSPPRPGRL CCEEEEECCCCCCCC	35.65	24719451
1052	Phosphorylation	QEIGVPLYQSPPGRY HHHCCCCCCCCCCCC	10.81	25884760
1054	Phosphorylation	IGVPLYQSPPGRYLS HCCCCCCCCCCCCCC	21.36	27732954
1061	Phosphorylation	SPPGRYLSPKKGANE CCCCCCCCCCCCCCC	26.24	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDH8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDH8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDH8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PCDH8_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.