PCD23_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCD23_HUMAN
• UniProt AC: Q6V1P9
• Protein Name: Protocadherin-23
• Gene Name: DCHS2
• Organism: Homo sapiens (Human).
• Sequence Length: 2916
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Calcium-dependent cell-adhesion protein..
• Protein Sequence: MRLDEITKSENEDGEKKMFTQQFESTDACVYEVYVKINSIVKSQSQCGLKRGSPETELWGAIVFRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLILICILIVMILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPEWLSLISIMEKDIVNLYRHSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSGIPRDSDQLSCLSGETDVMVTAETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKREAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASVFNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPRSPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDEVQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	KINSIVKSQSQCGLK EHHHHHCCHHHCCCC	24.95	23403867
45	Phosphorylation	NSIVKSQSQCGLKRG HHHHCCHHHCCCCCC	34.23	23403867
220	N-linked_Glycosylation	AYELIPGNVSSLFTI EEEEECCCCCCCEEE	25.74	UniProtKB CARBOHYD
245	N-linked_Glycosylation	VEILSAVNFSADKEV EEEEEECCCCCCHHH	25.52	UniProtKB CARBOHYD
298	Phosphorylation	KGRRHLHYLKVQDEA ECCEEEEEEEEECHH	17.99	22817900
387	Phosphorylation	PKYTFLVYEDVPEDS CCEEEEEEECCCCCC	14.46	-
406	N-linked_Glycosylation	VKAREPLNSSEPIFY EEECCCCCCCCCEEE	54.96	UniProtKB CARBOHYD
467	N-linked_Glycosylation	ACSSTEVNITVMDVN CCCCCEEEEEEEECC	20.27	UniProtKB CARBOHYD
539	N-linked_Glycosylation	ALGVLFLNGSLGAGE HHEEEEECCCCCCCC	30.58	UniProtKB CARBOHYD
623	Phosphorylation	RAASPLRYSLEPSVD CCCCCCCEECCCCCC	25.87	22468782
669	N-linked_Glycosylation	FAWIPEDGFLQNVST EEEECCCCCCCCCCE	24.41	-
673	N-linked_Glycosylation	PEDGFLQNVSTTVIV CCCCCCCCCCEEEEE	31.67	UniProtKB CARBOHYD
704	Phosphorylation	LFLKVEESPVPQGVI EEEEEECCCCCCCCE	20.07	-
715	Phosphorylation	QGVIGKITAIDMDSG CCCEEEEEEEECCCC	22.50	-
721	Phosphorylation	ITAIDMDSGKNGQLL EEEEECCCCCCCEEE	45.06	-
752 (in isoform 4)	Phosphorylation	-	2.51	-
772	N-linked_Glycosylation	TDFAFSSDELQAFVL CCCCCCHHHHHHHHH	60.47	-
814	N-linked_Glycosylation	MTVLVTDRGSPPRNA EEEEEECCCCCCCCC	37.82	-
820	N-linked_Glycosylation	DRGSPPRNATMAVYV CCCCCCCCCEEEEEE	45.60	UniProtKB CARBOHYD
905	N-linked_Glycosylation	GEIRTTTILSYDYRP CEEEEEEEEEEECCC	1.95	-
913	Phosphorylation	LSYDYRPSYRMSVIA EEEECCCCCEEEEEE	19.17	22322096
914	Phosphorylation	SYDYRPSYRMSVIAT EEECCCCCEEEEEEE	17.02	-
964	Phosphorylation	IPENLKPTKIMSLIK CCCCCCCCCHHHHHH	31.45	29083192
966	N-linked_Glycosylation	ENLKPTKIMSLIKSS CCCCCCCHHHHHHCC	2.20	-
968	Phosphorylation	LKPTKIMSLIKSSDH CCCCCHHHHHHCCHH	30.34	24719451
1032	N-linked_Glycosylation	ITTDHSKNLSLSSTV EECCCCCCCCCCEEE	37.57	UniProtKB CARBOHYD
1038	N-linked_Glycosylation	KNLSLSSTVFLSIDV CCCCCCEEEEEEEEC	16.35	-
1090	Methylation	DGSFLNSRIQYYIES CCCCHHHEEEEEHHH	20.96	-
1118	Phosphorylation	FGTLVTVSRLDRESI CCCEEEEEECCHHCC	20.12	24719451
1140	N-linked_Glycosylation	TASDQAVNVTDRRLR ECCCCCCCCCHHHHH	33.71	UniProtKB CARBOHYD
1172	N-linked_Glycosylation	FISFPNAHVKEDVTV EEECCCCCCCCCCCH	37.51	-
1209	N-linked_Glycosylation	SILSGNENMTFMLDE EEEECCCCEEEEEEC	38.50	UniProtKB CARBOHYD
1275	N-linked_Glycosylation	VFKQHLYEASVKENQ HHHHEEEEHHCCCCC	40.61	-
1341	Phosphorylation	REIQEVFTLRVLVRD HHHHEEEEEEEEEEC	20.87	24719451
1363 (in isoform 4)	Phosphorylation	-	24.39	27251275
1364 (in isoform 4)	Phosphorylation	-	9.47	27251275
1443	N-linked_Glycosylation	LDREQISNFTLVILC CCHHHHCCCEEEEEE	35.24	UniProtKB CARBOHYD
1487	N-linked_Glycosylation	TLYYQSSVREDAEVG CEEEECCCCCCCCCC	10.60	-
1537	Phosphorylation	MSGTLKTSNTLDREA CCCCEECCCCCCHHH	26.65	-
1539	Phosphorylation	GTLKTSNTLDREARS CCEECCCCCCHHHHH	29.78	-
1595	N-linked_Glycosylation	FDVFLSPESPTNQTT CCEECCCCCCCCCCE	67.01	-
1599	N-linked_Glycosylation	LSPESPTNQTTVIVR CCCCCCCCCCEEEEE	40.35	UniProtKB CARBOHYD
1615	N-linked_Glycosylation	DDLDLGPNGTVVFSF CCCCCCCCCEEEEEE	57.90	UniProtKB CARBOHYD
1617	N-linked_Glycosylation	LDLGPNGTVVFSFAE CCCCCCCEEEEEEEE	21.82	-
1664	N-linked_Glycosylation	VTDQGIPARTTTGLL ECCCCCCCCEEEEEE	21.38	-
1732	Phosphorylation	GNEDGVLSLCSKSGQ CCCCCCEEEEECCCC	25.56	-
1735	Phosphorylation	DGVLSLCSKSGQLTV CCCEEEEECCCCEEE	34.84	-
1874	N-linked_Glycosylation	KGMPRLSNTTVIKVQ CCCCCCCCEEEEEEE	44.34	UniProtKB CARBOHYD
1898	N-linked_Glycosylation	AFLPSEAVEITEDSL CCCCHHHEECCCCCC	4.86	-
1944	Phosphorylation	KFAIDQNTGVVVLVK CEEEECCCCEEEEEE	26.22	24043423
1959	Phosphorylation	TLDFEEMTEYELLIQ ECCHHHCCCEEEEEE	38.40	24043423
1961	Phosphorylation	DFEEMTEYELLIQIS CHHHCCCEEEEEEEC	11.60	24043423
1968	Phosphorylation	YELLIQISDSVHYTE EEEEEEECCCCCCCC	13.88	24043423
1970	Phosphorylation	LLIQISDSVHYTEGA EEEEECCCCCCCCCE	12.19	24043423
1973	Phosphorylation	QISDSVHYTEGALVV EECCCCCCCCCEEEE	12.34	24043423
1974	Phosphorylation	ISDSVHYTEGALVVR ECCCCCCCCCEEEEE	17.05	24043423
2024	N-linked_Glycosylation	TDLESNENISYRILS ECCCCCCCEEEEEEC	32.53	UniProtKB CARBOHYD
2042	N-linked_Glycosylation	EFSIDPKNGTIFTIS CEEECCCCCCEEEEC	59.22	UniProtKB CARBOHYD
2054	N-linked_Glycosylation	TISPVLLLDTISTTQ EECCEEEEECCCCCE	4.83	-
2070	N-linked_Glycosylation	LVEASDGGNPDLRAL EEECCCCCCCCCEEE	47.70	-
2098	N-linked_Glycosylation	APEFTVKSYNLSLSE CCEEEEEEECCCCCC	18.21	-
2100	N-linked_Glycosylation	EFTVKSYNLSLSEDA EEEEEEECCCCCCCC	30.19	UniProtKB CARBOHYD
2124	Phosphorylation	SNIDHDWTRENTYVE CCCCCCCCCCCCEEE	33.88	24719451
2209	N-linked_Glycosylation	DVNDNPPNFSSLSYH ECCCCCCCCCCEEEE	51.17	UniProtKB CARBOHYD
2230	Phosphorylation	TPLGSHITVVSANDR CCCCCCEEEEECCCC	14.94	30576142
2233	Phosphorylation	GSHITVVSANDRDTG CCCEEEEECCCCCCC	19.61	30576142
2329	N-linked_Glycosylation	IVPENLPISSTICSI ECCCCCCCCCEEEEE	5.98	-
2474	N-linked_Glycosylation	SSPFFSVNKTNGNIY CCCCEEEECCCCCEE	44.21	UniProtKB CARBOHYD
2476	Phosphorylation	PFFSVNKTNGNIYLI CCEEEECCCCCEEEE	43.06	-
2479	N-linked_Glycosylation	SVNKTNGNIYLIRAL EEECCCCCEEEEECH	23.08	-
2497	N-linked_Glycosylation	KSQLNKEDTLEMKII HHHCCCCCCEEEEEE	59.19	-
2498	Phosphorylation	SQLNKEDTLEMKIIA HHCCCCCCEEEEEEE	26.21	28165663
2522	N-linked_Glycosylation	ASCTVFVNVSFSSEG CCEEEEEEEEECCCC	16.55	UniProtKB CARBOHYD
2555	N-linked_Glycosylation	LVFLILICILIVMIL HHHHHHHHHHHHHHH	1.53	-
2567	Ubiquitination	MILRHKQKDTINNYE HHHHHCCCCCCCCCC	62.74	-
2576	Ubiquitination	TINNYEEKKTSSLDA CCCCCCCHHHCCCCC	49.78	-
2577	Ubiquitination	INNYEEKKTSSLDAD CCCCCCHHHCCCCCC	57.85	-
2580	Phosphorylation	YEEKKTSSLDADLRV CCCHHHCCCCCCCCC	35.18	25690035
2588	Phosphorylation	LDADLRVTRDASVLK CCCCCCCCCCHHHHH	19.19	29759185
2592	Phosphorylation	LRVTRDASVLKAFQK CCCCCCHHHHHHHHC	32.07	29759185
2635	N-linked_Glycosylation	VNLYRHSNSSGHCSV HHHHHCCCCCCCCCC	33.79	UniProtKB CARBOHYD
2664	N-linked_Glycosylation	EHPYRKCSDSALSDH CCCCCCCCHHHCCCC	37.32	-
2669	Phosphorylation	KCSDSALSDHESRVP CCCHHHCCCCCCCCC	36.32	22964224
2747	Trimethylation	SILADVRKESVFISG HHHHHHHHHCEEEEC	54.94	-
2747	Methylation	SILADVRKESVFISG HHHHHHHHHCEEEEC	54.94	23644510
2888	Phosphorylation	TMQPPALSPLLREGE CCCCCCCHHHHHCCC	18.66	24719451
2929	N-linked_Glycosylation	-------------------- --------------------		-
2977	N-linked_Glycosylation	-------------------------------------------------------------------- --------------------------------------------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCD23_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCD23_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCD23_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PCD23_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.