PCCA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCCA_MOUSE
• UniProt AC: Q91ZA3
• Protein Name: Propionyl-CoA carboxylase alpha chain, mitochondrial
• Gene Name: Pcca
• Organism: Mus musculus (Mouse).
• Sequence Length: 724
• Subcellular Localization: Mitochondrion matrix.
• Protein Sequence: MAGQWVRTVALLAARRHWRRSSQQQLLGTLKHAPVYSYQCLVVSRSLSSVEYEPKEKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFAKRLAAEDVTFIGPDTHAIQAMGDKIESKLLAKRAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDPETRQAMGEQAVALAKAVKYSSAGTVEFLVDSQKNFYFLEMNTRLQVEHPVTECITGLDLVQEMILVAKGYPLRHKQEDIPISGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPIHLPGVRVDSGIQPGSDISIYYDPMISKLVTYGSDRAEALKRMEDALDNYVIRGVTHNIPLLREVIINTRFVKGDISTKFLSDVYPDGFKGHTLTLSERNQLLAIASSVFVASQLRAQRFQEHSRVPVIRPDVAKWELSVKLHDEDHTVVASNNGPAFTVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTVQCLSREAGGNMSIQFLGTVYKVHILTKLAAELNKFMLEKVPKDTSSTLCSPMPGVVVAVSVKPGDMVAEGQEICVIEAMKMQNSMTAGKMGKVKLVHCKAGDTVGEGDLLVELE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Acetylation	VEYEPKEKTFDKILI CCCCCCCCCCCEEEE	61.69	23864654
61	Succinylation	PKEKTFDKILIANRG CCCCCCCEEEEECCH	34.91	-
61	Acetylation	PKEKTFDKILIANRG CCCCCCCEEEEECCH	34.91	23576753
61	Succinylation	PKEKTFDKILIANRG CCCCCCCEEEEECCH	34.91	23806337
84	Acetylation	TCKKMGIKTVAIHSD HHHHCCCEEEEEECC	31.08	24062335
107	S-palmitoylation	KMADEAVCVGPAPTS EECCCEEEECCCCCC	3.64	28526873
107	S-nitrosylation	KMADEAVCVGPAPTS EECCCEEEECCCCCC	3.64	21278135
107	S-nitrosocysteine	KMADEAVCVGPAPTS EECCCEEEECCCCCC	3.64	-
114	Phosphorylation	CVGPAPTSKSYLNMD EECCCCCCHHHCCHH	20.67	21082442
115	Acetylation	VGPAPTSKSYLNMDA ECCCCCCHHHCCHHH	45.67	23806337
115	Succinylation	VGPAPTSKSYLNMDA ECCCCCCHHHCCHHH	45.67	23806337
115	Succinylation	VGPAPTSKSYLNMDA ECCCCCCHHHCCHHH	45.67	-
128	Succinylation	DAIMEAIKKTRAQAV HHHHHHHHHHHHHHC	55.96	26388266
128	Acetylation	DAIMEAIKKTRAQAV HHHHHHHHHHHHHHC	55.96	23864654
129	Succinylation	AIMEAIKKTRAQAVH HHHHHHHHHHHHHCC	36.81	26388266
146	Acetylation	YGFLSENKEFAKRLA CCCHHCCHHHHHHHH	50.59	23576753
146	Succinylation	YGFLSENKEFAKRLA CCCHHCCHHHHHHHH	50.59	23806337
146	Succinylation	YGFLSENKEFAKRLA CCCHHCCHHHHHHHH	50.59	-
150	Succinylation	SENKEFAKRLAAEDV HCCHHHHHHHHHCCC	53.95	24315375
150	Acetylation	SENKEFAKRLAAEDV HCCHHHHHHHHHCCC	53.95	23576753
184	Succinylation	KLLAKRAKVNTIPGF HHHHHHCCCCCCCCC	39.80	-
184	Acetylation	KLLAKRAKVNTIPGF HHHHHHCCCCCCCCC	39.80	23806337
184	Glutarylation	KLLAKRAKVNTIPGF HHHHHHCCCCCCCCC	39.80	24703693
184	Succinylation	KLLAKRAKVNTIPGF HHHHHHCCCCCCCCC	39.80	23806337
196	Acetylation	PGFDGVVKDADEAVR CCCCCCCCCHHHHHH	44.80	23576753
196	Succinylation	PGFDGVVKDADEAVR CCCCCCCCCHHHHHH	44.80	23806337
196	Succinylation	PGFDGVVKDADEAVR CCCCCCCCCHHHHHH	44.80	-
223	Succinylation	ASAGGGGKGMRIAWD EECCCCCCCCEEEEC	53.46	23806337
223	Acetylation	ASAGGGGKGMRIAWD EECCCCCCCCEEEEC	53.46	23806337
242	Phosphorylation	RDGFRFSSQEAASSF CCCCCCCHHHHHHHH	29.36	23984901
247	Phosphorylation	FSSQEAASSFGDDRL CCHHHHHHHHCCCEE	32.99	25521595
248	Phosphorylation	SSQEAASSFGDDRLL CHHHHHHHHCCCEEE	28.64	25521595
258	Ubiquitination	DDRLLIEKFIDNPRH CCEEEHHHHCCCCCE	40.40	-
258	Succinylation	DDRLLIEKFIDNPRH CCEEEHHHHCCCCCE	40.40	23806337
258	Succinylation	DDRLLIEKFIDNPRH CCEEEHHHHCCCCCE	40.40	-
258	Acetylation	DDRLLIEKFIDNPRH CCEEEHHHHCCCCCE	40.40	23864654
301	Phosphorylation	KVVEEAPSIFLDPET HHHHHCCCCCCCHHH	32.78	-
321	Acetylation	EQAVALAKAVKYSSA HHHHHHHHHHHHCCC	55.34	23201123
324	Acetylation	VALAKAVKYSSAGTV HHHHHHHHHCCCCEE	44.25	23576753
324	Succinylation	VALAKAVKYSSAGTV HHHHHHHHHCCCCEE	44.25	23806337
324	Succinylation	VALAKAVKYSSAGTV HHHHHHHHHCCCCEE	44.25	-
359	Glutathionylation	VEHPVTECITGLDLV ECCCHHHHCCCHHHH	2.17	24333276
359	S-nitrosylation	VEHPVTECITGLDLV ECCCHHHHCCCHHHH	2.17	21278135
359	S-palmitoylation	VEHPVTECITGLDLV ECCCHHHHCCCHHHH	2.17	28526873
359	S-nitrosocysteine	VEHPVTECITGLDLV ECCCHHHHCCCHHHH	2.17	-
381	Acetylation	KGYPLRHKQEDIPIS CCCCCCCCCCCCCCC	49.28	23806337
381	Succinylation	KGYPLRHKQEDIPIS CCCCCCCCCCCCCCC	49.28	23806337
381	Succinylation	KGYPLRHKQEDIPIS CCCCCCCCCCCCCCC	49.28	-
394	S-nitrosylation	ISGWAVECRVYAEDP CCCEEEEEEEEECCC	2.61	21278135
394	S-nitrosocysteine	ISGWAVECRVYAEDP CCCEEEEEEEEECCC	2.61	-
394	S-palmitoylation	ISGWAVECRVYAEDP CCCEEEEEEEEECCC	2.61	28526873
403	Succinylation	VYAEDPYKSFGLPSI EEECCCCHHCCCCCC	44.70	23806337
403	Succinylation	VYAEDPYKSFGLPSI EEECCCCHHCCCCCC	44.70	-
403	Ubiquitination	VYAEDPYKSFGLPSI EEECCCCHHCCCCCC	44.70	-
403	Acetylation	VYAEDPYKSFGLPSI EEECCCCHHCCCCCC	44.70	23864654
460	Acetylation	SDRAEALKRMEDALD HHHHHHHHHHHHHHH	57.66	2374015
492	Succinylation	IINTRFVKGDISTKF HHHCCCCCCCCCHHH	48.42	23806337
492	Acetylation	IINTRFVKGDISTKF HHHCCCCCCCCCHHH	48.42	23576753
492	Glutarylation	IINTRFVKGDISTKF HHHCCCCCCCCCHHH	48.42	24703693
498	Succinylation	VKGDISTKFLSDVYP CCCCCCHHHHHCCCC	37.20	23806337
498	Acetylation	VKGDISTKFLSDVYP CCCCCCHHHHHCCCC	37.20	23864654
498	Succinylation	VKGDISTKFLSDVYP CCCCCCHHHHHCCCC	37.20	-
509	Succinylation	DVYPDGFKGHTLTLS CCCCCCCCCCEEEHH	56.14	-
509	Acetylation	DVYPDGFKGHTLTLS CCCCCCCCCCEEEHH	56.14	23954790
509	Succinylation	DVYPDGFKGHTLTLS CCCCCCCCCCEEEHH	56.14	23806337
512	Phosphorylation	PDGFKGHTLTLSERN CCCCCCCEEEHHHHH	30.06	-
554	Succinylation	VIRPDVAKWELSVKL EECCCCEEEEEEEEE	40.84	-
554	Acetylation	VIRPDVAKWELSVKL EECCCCEEEEEEEEE	40.84	23864654
554	Succinylation	VIRPDVAKWELSVKL EECCCCEEEEEEEEE	40.84	23806337
637	Acetylation	YKVHILTKLAAELNK HHHHHHHHHHHHHHH	32.46	23201123
644	Succinylation	KLAAELNKFMLEKVP HHHHHHHHHHHHCCC	44.79	-
644	Acetylation	KLAAELNKFMLEKVP HHHHHHHHHHHHCCC	44.79	23806337
644	Succinylation	KLAAELNKFMLEKVP HHHHHHHHHHHHCCC	44.79	23806337
649	Succinylation	LNKFMLEKVPKDTSS HHHHHHHCCCCCCCC	60.93	23806337
649	Acetylation	LNKFMLEKVPKDTSS HHHHHHHCCCCCCCC	60.93	23806337
690	N6-biotinyllysine	ICVIEAMKMQNSMTA EEEEEEEHHCCCCCC	44.36	-
690	Biotinylation	ICVIEAMKMQNSMTA EEEEEEEHHCCCCCC	44.36	-
704	Acetylation	AGKMGKVKLVHCKAG CCCCCCEEEEEECCC	48.56	23201123

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCCA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCCA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCCA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PCCA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.