PARI_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PARI_MOUSE
• UniProt AC: Q6IRT3
• Protein Name: PCNA-interacting partner
• Gene Name: Parpbp
• Organism: Mus musculus (Mouse).
• Sequence Length: 573
• Subcellular Localization: Cytoplasm. Nucleus. Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA (By similarity)..
• Protein Description: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity)..
• Protein Sequence: MAVLNQLPVLGMIKEFRRSWRALCSSERTTLCGPDSMLLALQLSMAENNKQHRGEFTVCLSDVLLTWKYFLHEKLNLPIENMKVVEHYEDIKKTYDDFLKNSNTLDLIDVYKKCSSLTSNYENNMISPIQLRDFLSGTEYAVSDEANPHMPESPVKCSQNDEQVRVLVKKIFFSYLSLLVNSKNDLALASILNIPDRGLGREAFTNLKHAAREKQLSMFLMATSFIRTLELGGKGYAPSPSDPLWAHVKGLSEFINFIDKLDEILGKIPNPSLAGSRILSAIKMQLIKGHSSGEPFYKAVEEVVQDLNLRIKNIINSQEGVAVSANNISPVPPKSFAINHDTAYCGRDAVKILLVLLDEDAASAPTRNKAELLYNDESTVPHSGPSVLTLFRSPTQEKNTSVKPLRERIHKSLQTEKNKMWQTLIRSQFACTYKDDCIMSKNKWHVNSSSKPLSALHLEDDVSEGAQSSVGKARIEASSENAHVGRWKGDKLPRKSTQRQISKGKQLDLDSENLHCDRGNELYQHKNIKIPKVPSGSHSKAGGKLAQGTKGNRCPARGKLIPGQTKLTQFFML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
317	Phosphorylation	RIKNIINSQEGVAVS HHHHHHHCCCCEEEE	21.14	25159016
324	Phosphorylation	SQEGVAVSANNISPV CCCCEEEECCCCCCC	18.62	25159016
329	Phosphorylation	AVSANNISPVPPKSF EEECCCCCCCCCHHH	23.20	25159016
383	Phosphorylation	DESTVPHSGPSVLTL CCCCCCCCCCCHHHE	46.45	26643407
386	Phosphorylation	TVPHSGPSVLTLFRS CCCCCCCCHHHEECC	33.03	26643407
389	Phosphorylation	HSGPSVLTLFRSPTQ CCCCCHHHEECCCCC	22.99	26643407
393	Phosphorylation	SVLTLFRSPTQEKNT CHHHEECCCCCCCCC	25.60	26643407
395	Phosphorylation	LTLFRSPTQEKNTSV HHEECCCCCCCCCCC	51.08	26643407
539	Phosphorylation	KVPSGSHSKAGGKLA CCCCCCCCCCCCCCC	26.37	28059163
559	Acetylation	NRCPARGKLIPGQTK CCCCCCCCCCCCCCC	37.38	15604659

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PARI_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PARI_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PARI_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PARI_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.