| UniProt ID | PAR4_HUMAN | |
|---|---|---|
| UniProt AC | Q96RI0 | |
| Protein Name | Proteinase-activated receptor 4 | |
| Gene Name | F2RL3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 385 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.. | |
| Protein Sequence | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 56 | N-linked_Glycosylation | YPGQVCANDSDTLEL CCCCCCCCCCCCCCC | 44.16 | 17660510 | |
| 359 | Phosphorylation | RAGLFQRSPGDTVAS HHHCCCCCCCCCHHH | 23.58 | 28450419 | |
| 363 | Phosphorylation | FQRSPGDTVASKASA CCCCCCCCHHHHCCC | 24.72 | 28060719 | |
| 366 | Phosphorylation | SPGDTVASKASAEGG CCCCCHHHHCCCCCC | 25.15 | 28450419 | |
| 367 | Ubiquitination | PGDTVASKASAEGGS CCCCHHHHCCCCCCC | 36.30 | - | |
| 369 | Phosphorylation | DTVASKASAEGGSRG CCHHHHCCCCCCCCC | 30.50 | 29970186 | |
| 374 | Phosphorylation | KASAEGGSRGMGTHS HCCCCCCCCCCCCCH | 36.20 | 28060719 | |
| 379 | Phosphorylation | GGSRGMGTHSSLLQ- CCCCCCCCCHHHCC- | 15.08 | 28060719 | |
| 381 | Phosphorylation | SRGMGTHSSLLQ--- CCCCCCCHHHCC--- | 23.63 | 28060719 | |
| 382 | Phosphorylation | RGMGTHSSLLQ---- CCCCCCHHHCC---- | 26.04 | 28060719 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PAR4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PAR4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PAR4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PAR4_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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