PAPP2_HUMAN - dbPTM
PAPP2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PAPP2_HUMAN
UniProt AC Q9BXP8
Protein Name Pappalysin-2
Gene Name PAPPA2
Organism Homo sapiens (Human).
Sequence Length 1791
Subcellular Localization Secreted.
Protein Description Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3..
Protein Sequence MMCLKILRISLAILAGWALCSANSELGWTRKKSLVEREHLNQVLLEGERCWLGAKVRRPRASPQHHLFGVYPSRAGNYLRPYPVGEQEIHHTGRSKPDTEGNAVSLVPPDLTENPAGLRGAVEEPAAPWVGDSPIGQSELLGDDDAYLGNQRSKESLGEAGIQKGSAMAATTTTAIFTTLNEPKPETQRRGWAKSRQRRQVWKRRAEDGQGDSGISSHFQPWPKHSLKHRVKKSPPEESNQNGGEGSYREAETFNSQVGLPILYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIIAGVFDNCSHTVSDKGWALGIRSGKDKGKRDARFFFSLCTDRVKKATILISHSRYQPGTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNSPFMASCRSLLLGGDSSEDGHYFRGHLGTLVFWSTALPQSHFQHSSQHSSGEEEATDLVLTASFEPVNTEWVPFRDEKYPRLEVLQGFEPEPEILSPLQPPLCGQTVCDNVELISQYNGYWPLRGEKVIRYQVVNICDDEGLNPIVSEEQIRLQHEALNEAFSRYNISWQLSVHQVHNSTLRHRVVLVNCEPSKIGNDHCDPECEHPLTGYDGGDCRLQGRCYSWNRRDGLCHVECNNMLNDFDDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKDAVTHLGGIVLSPAYYGMPGHTDTMIHEVGHVLGLYHVFKGVSERESCNDPCKETVPSMETGDLCADTAPTPKSELCREPEPTSDTCGFTRFPGAPFTNYMSYTDDNCTDNFTPNQVARMHCYLDLVYQQWTESRKPTPIPIPPMVIGQTNKSLTIHWLPPISGVVYDRASGSLCGACTEDGTFRQYVHTASSRRVCDSSGYWTPEEAVGPPDVDQPCEPSLQAWSPEVHLYHMNMTVPCPTEGCSLELLFQHPVQADTLTLWVTSFFMESSQVLFDTEILLENKESVHLGPLDTFCDIPLTIKLHVDGKVSGVKVYTFDERIEIDAALLTSQPHSPLCSGCRPVRYQVLRDPPFASGLPVVVTHSHRKFTDVEVTPGQMYQYQVLAEAGGELGEASPPLNHIHGAPYCGDGKVSERLGEECDDGDLVSGDGCSKVCELEEGFNCVGEPSLCYMYEGDGICEPFERKTSIVDCGIYTPKGYLDQWATRAYSSHEDKKKCPVSLVTGEPHSLICTSYHPDLPNHRPLTGWFPCVASENETQDDRSEQPEGSLKKEDEVWLKVCFNRPGEARAIFIFLTTDGLVPGEHQQPTVTLYLTDVRGSNHSLGTYGLSCQHNPLIINVTHHQNVLFHHTTSVLLNFSSPRVGISAVALRTSSRIGLSAPSNCISEDEGQNHQGQSCIHRPCGKQDSCPSLLLDHADVVNCTSIGPGLMKCAITCQRGFALQASSGQYIRPMQKEILLTCSSGHWDQNVSCLPVDCGVPDPSLVNYANFSCSEGTKFLKRCSISCVPPAKLQGLSPWLTCLEDGLWSLPEVYCKLECDAPPIILNANLLLPHCLQDNHDVGTICKYECKPGYYVAESAEGKVRNKLLKIQCLEGGIWEQGSCIPVVCEPPPPVFEGMYECTNGFSLDSQCVLNCNQEREKLPILCTKEGLWTQEFKLCENLQGECPPPPSELNSVEYKCEQGYGIGAVCSPLCVIPPSDPVMLPENITADTLEHWMEPVKVQSIVCTGRRQWHPDPVLVHCIQSCEPFQADGWCDTINNRAYCHYDGGDCCSSTLSSKKVIPFAADCDLDECTCRDPKAEENQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationCLKILRISLAILAGW
HHHHHHHHHHHHHHH		12.81-
21PhosphorylationLAGWALCSANSELGW
HHHHHHHHCCCCCCC		31.19-
24PhosphorylationWALCSANSELGWTRK
HHHHHCCCCCCCCCC		33.64-
29PhosphorylationANSELGWTRKKSLVE
CCCCCCCCCCHHHHC		30.71-
153PhosphorylationAYLGNQRSKESLGEA
CCCCCHHHHHHHHHH		30.8929759185
156PhosphorylationGNQRSKESLGEAGIQ
CCHHHHHHHHHHHCH		45.4722210691
179PhosphorylationTTTAIFTTLNEPKPE
EEEEEEECCCCCCHH		19.4822210691
234PhosphorylationLKHRVKKSPPEESNQ
HHHCCCCCCCCHHCC		39.71-
239PhosphorylationKKSPPEESNQNGGEG
CCCCCCHHCCCCCCC		41.89-
311N-linked_GlycosylationIIAGVFDNCSHTVSD
EEEEEECCCCCCCCC		20.09UniProtKB CARBOHYD
357PhosphorylationATILISHSRYQPGTW
EEEEEECCCCCCCCE		26.37-
379PhosphorylationDGRHMALYVDGTQVA
CCCEEEEEECHHHHC		6.2223532336
387PhosphorylationVDGTQVASSLDQSGP
ECHHHHCCCCCCCCC		32.3623532336
562N-linked_GlycosylationNEAFSRYNISWQLSV
HHHHHHHCEEEEEEE		22.25UniProtKB CARBOHYD
574N-linked_GlycosylationLSVHQVHNSTLRHRV
EEEEEECCCCCCEEE		37.52UniProtKB CARBOHYD
666PhosphorylationPDSPKRAYMSVKELK
CCCHHHHCCCHHHHH		8.2429514088
668PhosphorylationSPKRAYMSVKELKEA
CHHHHCCCHHHHHHH		19.8429514088
679N-linked_GlycosylationLKEALQLNSTHFLNI
HHHHHHCCCCHHHHE		31.72UniProtKB CARBOHYD
804PhosphorylationRFPGAPFTNYMSYTD
CCCCCCCCCCCCCCC		25.12-
806PhosphorylationPGAPFTNYMSYTDDN
CCCCCCCCCCCCCCC		5.60-
813N-linked_GlycosylationYMSYTDDNCTDNFTP
CCCCCCCCCCCCCCH		33.14UniProtKB CARBOHYD
829PhosphorylationQVARMHCYLDLVYQQ
HHHHHHHHHHHHHHH		6.6425884760
834PhosphorylationHCYLDLVYQQWTESR
HHHHHHHHHHHHCCC		11.4125884760
857N-linked_GlycosylationPMVIGQTNKSLTIHW
CEEECCCCCCEEEEE		24.83UniProtKB CARBOHYD
908PhosphorylationRVCDSSGYWTPEEAV
EEECCCCCCCHHHHC		14.20-
910PhosphorylationCDSSGYWTPEEAVGP
ECCCCCCCHHHHCCC		16.61-
941N-linked_GlycosylationEVHLYHMNMTVPCPT
CEEEEEECCEEECCC		15.06UniProtKB CARBOHYD
1023PhosphorylationKVSGVKVYTFDERIE
EECEEEEEEECCCEE		8.9327499020
1024PhosphorylationVSGVKVYTFDERIEI
ECEEEEEEECCCEEE		27.8327499020
1087PhosphorylationEVTPGQMYQYQVLAE
EECCCCEEEEEHHHH		9.0022210691
1089PhosphorylationTPGQMYQYQVLAEAG
CCCCEEEEEHHHHCC		5.3222210691
1114PhosphorylationNHIHGAPYCGDGKVS
CCCCCCCCCCCCCHH		14.4522210691
1121PhosphorylationYCGDGKVSERLGEEC
CCCCCCHHHHHCCCC		22.0822210691
1197PhosphorylationQWATRAYSSHEDKKK
HHHHHHHCCCCCCCC		25.0029449344
1198PhosphorylationWATRAYSSHEDKKKC
HHHHHHCCCCCCCCC		20.4429449344
1243N-linked_GlycosylationFPCVASENETQDDRS
CCCEECCCCCCCCCC		55.94UniProtKB CARBOHYD
1308N-linked_GlycosylationLTDVRGSNHSLGTYG
EEECCCCCCCCCCCC		31.43UniProtKB CARBOHYD
1326N-linked_GlycosylationQHNPLIINVTHHQNV
CCCCEEEEEEECCCC		26.16UniProtKB CARBOHYD
1344N-linked_GlycosylationHTTSVLLNFSSPRVG
ECCCHHCCCCCCCCE		30.50UniProtKB CARBOHYD
1408N-linked_GlycosylationLDHADVVNCTSIGPG
CCCCCEEECCCCCCC		24.17UniProtKB CARBOHYD
1456N-linked_GlycosylationSSGHWDQNVSCLPVD
CCCCCCCCCCEEEEC		25.79UniProtKB CARBOHYD
1476N-linked_GlycosylationPSLVNYANFSCSEGT
HHHCHHCCEECCCCC		21.00UniProtKB CARBOHYD
1694N-linked_GlycosylationDPVMLPENITADTLE
CCCCCCCCCCHHHHH		34.66UniProtKB CARBOHYD
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PAPP2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PAPP2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PAPP2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IBP3_HUMANIGFBP3physical
11264294
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PAPP2_HUMAN

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Related Literatures of Post-Translational Modification

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