PAPD7_HUMAN - dbPTM
PAPD7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PAPD7_HUMAN
UniProt AC Q5XG87
Protein Name Non-canonical poly(A) RNA polymerase PAPD7
Gene Name PAPD7
Organism Homo sapiens (Human).
Sequence Length 772
Subcellular Localization Cytoplasm . Nucleus, nucleoplasm . Excluded from nucleolus, weak staining detected in the cytoplasm.
Protein Description Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation..
Protein Sequence MQIWETSQGVGRGGSGFASYFCLNSPALDTAAAAGAAGRGSGGLGPALPAASPPPPGPTAPAALPPALLTALGPAAEGARRLHKSPSLSSSSSSSSSNAESGTESPGCSSSSSSSASLGRPGGGRGGAFFNFADGAPSAPGTANGHPGPRGPAPAGSPSQHQFHPGRRKRENKASTYGLNYLLSGSRAAALSGGGGPGAQAPRPGTPWKSRAYSPGIQGLHEEIIDFYNFMSPCPEEAAMRREVVKRIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGGISSYSLILMAISFLQLHPRIDARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLARSYPNRDAESTLGRIIKVTQEVIDYRRWIKEKWGSKAHPSPGMDSRIKIKERIATCNGEQTQNREPESPYGQRLTLSLSSPQLLSSGSSASSVSSLSGSDVDSDTPPCTTPSVYQFSLQAPAPLMAGLPTALPMPSGKPQPTTSRTLIMTTNNQTRFTIPPPTLGVAPVPCRQAGVEGTASLKAVHHMSSPAIPSASPNPLSSPHLYHKQHNGMKLSMKGSHGHTQGGGYSSVGSGGVRPPVGNRGHHQYNRTGWRRKKHTHTRDSLPVSLSR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41PhosphorylationAGAAGRGSGGLGPAL
HCCCCCCCCCCCCCC		3.9329496963
70UbiquitinationALPPALLTALGPAAE
CCCHHHHHHHHHHHH		40.14-
80UbiquitinationGPAAEGARRLHKSPS
HHHHHHHHHHHCCCC		22.05-
84UbiquitinationEGARRLHKSPSLSSS
HHHHHHHCCCCCCCC		41.62-
91UbiquitinationKSPSLSSSSSSSSSN
CCCCCCCCCCCCCCC		46.16-
157PhosphorylationRGPAPAGSPSQHQFH
CCCCCCCCCCCCCCC		1.7125159151
175PhosphorylationRKRENKASTYGLNYL
CCCCCHHHHHCHHHH		23.9429116813
177PhosphorylationRENKASTYGLNYLLS
CCCHHHHHCHHHHHH		54.0629496907
181PhosphorylationASTYGLNYLLSGSRA
HHHHCHHHHHHHCCH		2.7029116813
184PhosphorylationYGLNYLLSGSRAAAL
HCHHHHHHHCCHHHH		5.4729116813
204UbiquitinationPGAQAPRPGTPWKSR
CCCCCCCCCCCCCCC		40.22-
309PhosphorylationNVAEPCSIKVLDKAT
CCCCCCEEEEECCCC		24.99-
314UbiquitinationCSIKVLDKATVPIIK
CEEEEECCCCCEEEE		27.32-
323PhosphorylationTVPIIKLTDQETEVK
CCEEEECCCCCEEEE		16.6022985185
337PhosphorylationKVDISFNMETGVRAA
EEEEEEECCCCCCHH		33.85-
339PhosphorylationDISFNMETGVRAAEF
EEEEECCCCCCHHHH		34.86-
350PhosphorylationAAEFIKNYMKKYSLL
HHHHHHHHHHHCCHH		26.01-
439PhosphorylationRIKEGGAYIAKEEIM
EECCCCEEECHHHHH		13.4029496907
475PhosphorylationNDVGRSSYGAMQVKQ
CCCCCCCCCCHHHHH		5.6329496907
486PhosphorylationQVKQVFDYAYIVLSH
HHHHHHHHHHHHHHH		16.9624043423
488PhosphorylationKQVFDYAYIVLSHAV
HHHHHHHHHHHHHHH		54.6124043423
492PhosphorylationDYAYIVLSHAVSPLA
HHHHHHHHHHHHHHH		27.5124043423
496PhosphorylationIVLSHAVSPLARSYP
HHHHHHHHHHHHCCC		32.4224043423
521MethylationIIKVTQEVIDYRRWI
HHHHHHHHHHHHHHH		29.67-
539PhosphorylationWGSKAHPSPGMDSRI
HCCCCCCCCCCCCHH		20.7730266825
541PhosphorylationSKAHPSPGMDSRIKI
CCCCCCCCCCCHHEH		28.56-
544PhosphorylationHPSPGMDSRIKIKER
CCCCCCCCHHEHHHH		30266825
567PhosphorylationTQNREPESPYGQRLT
CCCCCCCCCCCCEEE		21815630
569PhosphorylationNREPESPYGQRLTLS
CCCCCCCCCCEEEEE		25839225
649PhosphorylationTSRTLIMTTNNQTRF
CCCEEEEECCCCEEE		-
689PhosphorylationKAVHHMSSPAIPSAS
EEHHHCCCCCCCCCC		25627689
701PhosphorylationSASPNPLSSPHLYHK
CCCCCCCCCCCCEEC		25627689
702PhosphorylationASPNPLSSPHLYHKQ
CCCCCCCCCCCEECC		24719451
729PhosphorylationGHTQGGGYSSVGSGG
CCCCCCCCCCCCCCC		25839225
731PhosphorylationTQGGGYSSVGSGGVR
CCCCCCCCCCCCCCC		28555341
751MethylationRGHHQYNRTGWRRKK
CCCCCCCCCCCCCCC		115488227
765PhosphorylationKHTHTRDSLPVSLSR
CCCCCCCCCCCCCCC		28555341
769PhosphorylationTRDSLPVSLSR----
CCCCCCCCCCC----		25159151
769O-linked_GlycosylationTRDSLPVSLSR----
CCCCCCCCCCC----		28657654
771PhosphorylationDSLPVSLSR------
CCCCCCCCC------		21815630
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PAPD7_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PAPD7_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PAPD7_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZCHC7_HUMANZCCHC7physical
21878619
LRP6_HUMANLRP6physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PAPD7_HUMAN

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Related Literatures of Post-Translational Modification

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