| UniProt ID | PANX3_HUMAN | |
|---|---|---|
| UniProt AC | Q96QZ0 | |
| Protein Name | Pannexin-3 | |
| Gene Name | PANX3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 392 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Cell junction, gap junction. |
|
| Protein Description | Structural component of the gap junctions and the hemichannels.. | |
| Protein Sequence | MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSSGSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPYVFWNELEKARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEFSCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLAHTAAE ------CCHHHHHHH | 33.97 | 24043423 | |
| 6 | Phosphorylation | --MSLAHTAAEYMLS --CCHHHHHHHHHHH | 23.19 | 24043423 | |
| 10 | Phosphorylation | LAHTAAEYMLSDALL HHHHHHHHHHHHHCC | 9.91 | 24043423 | |
| 13 | Phosphorylation | TAAEYMLSDALLPDR HHHHHHHHHHCCCCC | 12.33 | 24043423 | |
| 45 | Phosphorylation | VKFVAVGSPLLLMSL HHHHHCCCHHHHHHH | 13.03 | 22210691 | |
| 60 | Phosphorylation | AFAQEFSSGSPISCF HHHHHHCCCCCCCCC | 48.92 | 22210691 | |
| 65 | Phosphorylation | FSSGSPISCFSPSNF HCCCCCCCCCCCCCC | 16.70 | 22210691 | |
| 71 | N-linked_Glycosylation | ISCFSPSNFSIRQAA CCCCCCCCCEEEHHE | 37.76 | UniProtKB CARBOHYD | |
| 154 | Phosphorylation | LDKSYNRSIRLVQHM HCHHCCHHHHHHHHH | 14.39 | - | |
| 204 | Phosphorylation | ACKQRSHSLVATYLL HHHHCCHHHHHHHHH | 26.28 | - | |
| 305 | Phosphorylation | DKRLLSVYEMLPAFD HHHHHHHHHHHHHHH | 7.70 | 28387310 | |
| 315 | Phosphorylation | LPAFDLLSRKMLGCP HHHHHHHHHHHHCCC | 36.83 | 30257219 | |
| 338 | Phosphorylation | LFLRANISELISFSW HHHHCCHHHHHHHHH | 26.59 | - | |
| 342 | Phosphorylation | ANISELISFSWLSVL CCHHHHHHHHHHHHH | 26.33 | - | |
| 355 | Phosphorylation | VLCVLKDTTTQKHNI HHHHHCCCCCCCCCH | 30.10 | 22210691 | |
| 364 | Phosphorylation | TQKHNIDTVVDFMTL CCCCCHHHHHHHHHH | 20.73 | - | |
| 370 | Phosphorylation | DTVVDFMTLLAGLEP HHHHHHHHHHHCCCC | 20.72 | 22210691 | |
| 378 | Phosphorylation | LLAGLEPSKPKHLTN HHHCCCCCCCCCCCC | 52.82 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PANX3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PANX3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PANX3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PANX3_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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