PANK2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PANK2_ARATH
• UniProt AC: Q8L5Y9
• Protein Name: Pantothenate kinase 2
• Gene Name: PANK2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 901
• Protein Description: Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration. Functionally redudant with PANK1..
• Protein Sequence: MAGQEDEYDPILDNKREAEAKSQVSVAADKNMAPSTSGTPIHRSGSRPQLDLSKAEIQGNLEERDPTILLPNQSDDISHLALDIGGSLIKLLYFSRHEDYSNDDDKRKRTIKERLGITNGNLRSYPVLGGRLHFVKFETHKINECLDFIHSKQLHRRDPYPWSSKTLPLGTGVIKVTGGGAFKFADLFKERLGVSIEKEDEMHCLVSGANFLLKAIRHEAFTHMEGEKEFVQIDPNDLYPYLLVNVGSGVSIIKVDGEGKFERVSGTNVGGGTYWGLGRLLTKCKSFDELLELSQKGDNSAIDMLVGDIYGGMDYSKIGLSASTIASSFGKAISENKELDDYRPEDISLSLLRMISYNIGQISYLNALRFGLKRIFFGGFFIRGHAYTMDTISFAVHFWSKGEMQAMFLRHEGFLGALGAFMSYEKHGLDDLMSHQLVERFPMGAPYTGGNIHGPPLGDLDEKISWMEKFVRRGTEITAPVPMTPSKTTGLGGFEVPSSRGSALRSDASALNVGVLHLVPTLEVFPLLADPKTYEPNTIDLSDQGEREYWLKVLSEHLPDLVDTAVASEGGTEDAKRRGDAFARAFSAHLARLMEEPAAYGKLGLANLLELREECLREFQFVDAYRSIKQRENEASLAVLPDLLEELDSMSEEARLLTLIEGVLAANIFDWGSRACVDLYHKGTIIEIYRMSRNKMQRPWRVDDFDAFKERMLGSGGKQPHRHKRALLFVDNSGADVILGMLPLAREFLRRGTEVVLVANSLPALNDVTAMELPDIVAGAAKHCDILRRAAEMGGLLVDAMVNPGDGSKKDSTSAPLMVVENGCGSPCIDLRQVSSELAAAAKDADLVVLEGMGRALHTNFNAQFQCEALKLAMVKNQRLAEKLIKGNIYDCVCRYEPPSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	SGTPIHRSGSRPQLD CCCCCCCCCCCCCCC	27.27	19880383
46	Phosphorylation	TPIHRSGSRPQLDLS CCCCCCCCCCCCCCC	41.87	30291188
53	Phosphorylation	SRPQLDLSKAEIQGN CCCCCCCCHHHHCCC	29.50	23776212
286	Phosphorylation	RLLTKCKSFDELLEL HHHHHCCCHHHHHHH	47.61	30291188
484	Phosphorylation	ITAPVPMTPSKTTGL EECCCCCCCCCCCCC	20.52	23111157
486	Phosphorylation	APVPMTPSKTTGLGG CCCCCCCCCCCCCCC	33.21	25561503
836	Phosphorylation	IDLRQVSSELAAAAK CCHHHHHHHHHHHHC	37.46	29654922

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PANK2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PANK2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PANK2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of PANK2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, AND MASSSPECTROMETRY.
PubMed: 19376835