dbPTM

PALLD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PALLD_MOUSE
UniProt AC	Q9ET54
Protein Name	Palladin
Gene Name	Palld
Organism	Mus musculus (Mouse).
Sequence Length	1408
Subcellular Localization	Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Cytoplasm, myofibril, sarcomere, Z line . Cell projection, ruffle . Cell projection, podosome . Cell projection, lamellipodium . Cell projection, axon . Cell projection, growth cone . Localize
Protein Description	Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific May be required for the initiation of neural tube closure..
Protein Sequence	MSETSSHDSFYDSLSDVQEEGKSADFFPGLSAFLSQEEINKSLDLARRAIDSSETEDFDSEKEISQIFSKSPISLCETPSHEEPKSGKQTSSERPQDSRRAPVQPLTGDQAERITSPGSKRKPGVSPLLASPSYIRSLRKAEKRGAKNPNPSSKPKTAQQSKAGPQSQLCDKAASFIEELTSIFREAAKPRNRSPNGESSSPDSGYLSPKNQPSALMSASASQSPTADQLDQLEMDAEVKQAQGSLCYQAHQASEETLPLAHIPHPQPQKARHLPTAPRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELYNSPDVQIHCESGELHTLVIAEAFEDDTGRYTCLATNPSGSDSTSAEVFIEGASSTDSDSESLSFISKAGAMPQAQKKTTSVSLTIGSSAPKTGVTTAVIQPLSVPVQQAHSATSYLCRPDGTTMGCLLPVFTKELQNTAASEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICTLVIAESFPEDAGIFTCSATNDYGSVTSTAQLVITSANNENCSYDSTGEPNSDHFQHFPPPPPILETGSYELASQKPSEIQQVNSPNLGFSMAALQMQFNTAERETNGVHPSHGVNGLINGKAYGNKSPPTPTALLSPTKEPPPLLAKPKLDPLKLQQLQNQVRLEQEACAWPPAPPGVPCNSSSSGSSAPPSPPFPPPPPAFPELAACASPVPSEPMSALASRATAMQSSGSFNYARPKQFIAAQNLGPASGLPTPTSSPSSSSLPSPLSPTPRPFGRAPGPPFVEPEAMWGPSSPSPPPPPPPVFSPSAAYPVPDVFPLPPPPPPLPSSTSHCASPARFGPSQTPAAFLSALLPSQPPPVAVNALGLPKGVTPAGFPKKSSRTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRLLGADSANVFNIQEPEETAANQDAGAPRASVGGPLDGQKEYKVSSCEQRLISEIEYRLERSPVDESGDEVQDPDVPVENATAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRVSCTGRLMVQAVNQRGRSPRSPSGHPHARRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFNLELVVAAKEAHKAPVFMEKLQNTGVADGYPVRLECRVSGVPPPQIFWKKENESLTHSTERVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQPQTTKPKKVRPSASRYAALSDQGLDIKAAFQPEASPSHLTLNSGLVESEDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 5)	Phosphorylation	-	44.83	26824392
6 (in isoform 5)	Phosphorylation	-	38.44	26824392
9 (in isoform 5)	Phosphorylation	-	21.93	29514104
15	Phosphorylation	DSFYDSLSDVQEEGK HHHHHCHHHHHHHCC	39.42	23737553
35	Phosphorylation	PGLSAFLSQEEINKS CCHHHHCCHHHHHHH	29.14	23737553
52	Phosphorylation	LARRAIDSSETEDFD HHHHHHCCCCCCCCC	24.78	23737553
53	Phosphorylation	ARRAIDSSETEDFDS HHHHHCCCCCCCCCC	44.80	23737553
55	Phosphorylation	RAIDSSETEDFDSEK HHHCCCCCCCCCCHH	42.68	23737553
60	Phosphorylation	SETEDFDSEKEISQI CCCCCCCCHHHHHHH	51.03	23737553
71	Phosphorylation	ISQIFSKSPISLCET HHHHHHCCCCCCCCC	26.68	27742792
116	Phosphorylation	DQAERITSPGSKRKP CHHHHCCCCCCCCCC	25.54	23737553
126	Phosphorylation	SKRKPGVSPLLASPS CCCCCCCCHHHCCHH	18.75	21183079
152	Phosphorylation	GAKNPNPSSKPKTAQ CCCCCCCCCCCCHHH	58.60	25159016
153	Phosphorylation	AKNPNPSSKPKTAQQ CCCCCCCCCCCHHHH	54.99	25159016
194	Phosphorylation	AAKPRNRSPNGESSS HCCCCCCCCCCCCCC	26.68	27742792
199	Phosphorylation	NRSPNGESSSPDSGY CCCCCCCCCCCCCCC	37.20	23737553
200	Phosphorylation	RSPNGESSSPDSGYL CCCCCCCCCCCCCCC	41.40	23737553
201	Phosphorylation	SPNGESSSPDSGYLS CCCCCCCCCCCCCCC	41.84	23737553
204	Phosphorylation	GESSSPDSGYLSPKN CCCCCCCCCCCCCCC	32.49	23737553
206	Phosphorylation	SSSPDSGYLSPKNQP CCCCCCCCCCCCCCC	14.14	23737553
208	Phosphorylation	SPDSGYLSPKNQPSA CCCCCCCCCCCCCCH	25.91	23737553
222	Phosphorylation	ALMSASASQSPTADQ HHHHCCCCCCCCHHH	28.79	23737553
224	Phosphorylation	MSASASQSPTADQLD HHCCCCCCCCHHHHH	23.02	23737553
226	Phosphorylation	ASASQSPTADQLDQL CCCCCCCCHHHHHHH	48.38	23737553
250 (in isoform 3)	Phosphorylation	-	3.12	26824392
401	Phosphorylation	QKKTTSVSLTIGSSA CCCCEEEEEEECCCC	21.40	28576409
486	Phosphorylation	VQWFRQGSEIQDSPD EEEEECCCCCCCCCC	24.16	26824392
589 (in isoform 4)	Phosphorylation	-	55.13	26824392
635	Phosphorylation	GLINGKAYGNKSPPT CEECCEECCCCCCCC	25.39	27742792
639	Phosphorylation	GKAYGNKSPPTPTAL CEECCCCCCCCCCCC	39.86	26824392
642	Phosphorylation	YGNKSPPTPTALLSP CCCCCCCCCCCCCCC	36.33	26824392
644	Phosphorylation	NKSPPTPTALLSPTK CCCCCCCCCCCCCCC	32.20	25263469
648	Phosphorylation	PTPTALLSPTKEPPP CCCCCCCCCCCCCCC	31.23	26824392
648 (in isoform 2)	Phosphorylation	-	31.23	29514104
650	Phosphorylation	PTALLSPTKEPPPLL CCCCCCCCCCCCCCC	44.67	21659605
676 (in isoform 2)	Phosphorylation	-	9.29	27566939
700	Phosphorylation	NSSSSGSSAPPSPPF CCCCCCCCCCCCCCC	48.60	-
704	Phosphorylation	SGSSAPPSPPFPPPP CCCCCCCCCCCCCCC	44.11	-
741	Phosphorylation	SRATAMQSSGSFNYA HHHHHHHCCCCCCCC	24.47	23984901
742	Phosphorylation	RATAMQSSGSFNYAR HHHHHHCCCCCCCCC	22.89	29472430
744	Phosphorylation	TAMQSSGSFNYARPK HHHHCCCCCCCCCHH	16.56	24899341
747	Phosphorylation	QSSGSFNYARPKQFI HCCCCCCCCCHHHEE	11.28	22817900
753 (in isoform 2)	Phosphorylation	-	5.25	26824392
762 (in isoform 2)	Phosphorylation	-	17.90	24719451
763	Phosphorylation	AQNLGPASGLPTPTS ECCCCCCCCCCCCCC	43.95	26160508
767	Phosphorylation	GPASGLPTPTSSPSS CCCCCCCCCCCCCCC	44.21	21659605
767 (in isoform 2)	Phosphorylation	-	44.21	24719451
769	Phosphorylation	ASGLPTPTSSPSSSS CCCCCCCCCCCCCCC	44.29	21659605
770	Phosphorylation	SGLPTPTSSPSSSSL CCCCCCCCCCCCCCC	41.26	26160508
771	Phosphorylation	GLPTPTSSPSSSSLP CCCCCCCCCCCCCCC	31.14	21659605
773	Phosphorylation	PTPTSSPSSSSLPSP CCCCCCCCCCCCCCC	44.81	23737553
774	Phosphorylation	TPTSSPSSSSLPSPL CCCCCCCCCCCCCCC	27.59	23737553
775	Phosphorylation	PTSSPSSSSLPSPLS CCCCCCCCCCCCCCC	39.99	21659605
776	Phosphorylation	TSSPSSSSLPSPLSP CCCCCCCCCCCCCCC	46.37	23737553
779	Phosphorylation	PSSSSLPSPLSPTPR CCCCCCCCCCCCCCC	43.71	26824392
782	Phosphorylation	SSLPSPLSPTPRPFG CCCCCCCCCCCCCCC	30.06	26824392
784	Phosphorylation	LPSPLSPTPRPFGRA CCCCCCCCCCCCCCC	28.67	21659605
806	Phosphorylation	PEAMWGPSSPSPPPP CHHCCCCCCCCCCCC	51.44	21189417
807	Phosphorylation	EAMWGPSSPSPPPPP HHCCCCCCCCCCCCC	32.31	23649490
809	Phosphorylation	MWGPSSPSPPPPPPP CCCCCCCCCCCCCCC	52.57	21189417
821	Phosphorylation	PPPVFSPSAAYPVPD CCCCCCCCCCCCCCC	25.08	23649490
885	Phosphorylation	LGLPKGVTPAGFPKK CCCCCCCCCCCCCCC	18.98	26824392
893	Phosphorylation	PAGFPKKSSRTARIA CCCCCCCCCCCEECC	31.04	23375375
896	Phosphorylation	FPKKSSRTARIASDE CCCCCCCCEECCCHH	23.41	23984901
901	Phosphorylation	SRTARIASDEEIQGT CCCEECCCHHHHCCC	43.09	27087446
908	Phosphorylation	SDEEIQGTKDAVIQD CHHHHCCCHHHHHHH	14.91	28833060
962 (in isoform 2)	Phosphorylation	-	14.01	24719451
973	Phosphorylation	DAGAPRASVGGPLDG CCCCCCCCCCCCCCC	23.68	28464351
978 (in isoform 6)	Phosphorylation	-	15.17	26824392
995	Phosphorylation	SCEQRLISEIEYRLE CHHHHHHHHHHHHHH	36.79	26824392
1004	Phosphorylation	IEYRLERSPVDESGD HHHHHHCCCCCCCCC	21.65	27087446
1009	Phosphorylation	ERSPVDESGDEVQDP HCCCCCCCCCCCCCC	47.26	27087446
1024	Phosphorylation	DVPVENATAPFFEMK CCCCCCCCCCCEEEE	46.58	25619855
1046	Phosphorylation	EGMPVTFTCRVAGNP CCCEEEEEEEECCCC	7.05	22807455
1056	Acetylation	VAGNPKPKIYWFKDG ECCCCCCEEEEEECC	55.33	22826441
1109 (in isoform 2)	Phosphorylation	-	7.63	29514104
1126	Phosphorylation	AVNQRGRSPRSPSGH HHHHCCCCCCCCCCC	27.73	28507225
1129	Phosphorylation	QRGRSPRSPSGHPHA HCCCCCCCCCCCCCC	27.14	27087446
1131	Phosphorylation	GRSPRSPSGHPHARR CCCCCCCCCCCCCCC	51.48	26824392
1141	Phosphorylation	PHARRPRSRSRDSGD CCCCCCCCCCCCCCC	36.97	25521595
1143	Phosphorylation	ARRPRSRSRDSGDEN CCCCCCCCCCCCCCC	41.51	25521595
1146	Phosphorylation	PRSRSRDSGDENEPI CCCCCCCCCCCCCCH	47.21	25521595
1184	Phosphorylation	CRMDCKVSGLPTPDL EECEEEECCCCCCCC	21.80	23649490
1188	Phosphorylation	CKVSGLPTPDLSWQL EEECCCCCCCCCEEE	34.18	23649490
1192	Phosphorylation	GLPTPDLSWQLDGKP CCCCCCCCEEECCEE	21.84	23649490
1204	Phosphorylation	GKPIRPDSAHKMLVR CEECCCCCHHHHHHH	34.65	26824392
1217	Phosphorylation	VRENGVHSLIIEPVT HHHCCCEEEEEECCC	20.89	30635358
1224	Phosphorylation	SLIIEPVTSRDAGIY EEEEECCCCCCCCEE	28.85	30635358
1225	Phosphorylation	LIIEPVTSRDAGIYT EEEECCCCCCCCEEE	28.53	30635358
1231	Phosphorylation	TSRDAGIYTCIATNR CCCCCCEEEEEECCC	8.47	30635358
1232	Phosphorylation	SRDAGIYTCIATNRA CCCCCEEEEEECCCC	8.77	30635358
1236	Phosphorylation	GIYTCIATNRAGQNS CEEEEEECCCCCCCC	12.82	30635358
1274	Phosphorylation	NTGVADGYPVRLECR HCCCCCCCCEEEEEE	10.09	-
1293	Acetylation	PPPQIFWKKENESLT CCCCEEEECCCCCCC	39.19	23236377
1298	Phosphorylation	FWKKENESLTHSTER EEECCCCCCCCCCCE	50.58	26824392
1300	Phosphorylation	KKENESLTHSTERVS ECCCCCCCCCCCEEE	24.06	26824392
1302	Phosphorylation	ENESLTHSTERVSMH CCCCCCCCCCEEEEC	27.08	26824392
1351	Phosphorylation	CTARLDVYTQWHQQP EEEEEEHHHHHHCCC	7.90	20116462
1352	Phosphorylation	TARLDVYTQWHQQPQ EEEEEHHHHHHCCCC	25.65	25777480
1373	Phosphorylation	VRPSASRYAALSDQG CCCCHHHHHHHHHCC	8.17	29514104
1377	Phosphorylation	ASRYAALSDQGLDIK HHHHHHHHHCCCCCE	24.14	26824392
1392	Phosphorylation	AAFQPEASPSHLTLN EECCCCCCCCCEEEC	25.85	24068923
1394	Phosphorylation	FQPEASPSHLTLNSG CCCCCCCCCEEECCC	28.74	24068923
1397	Phosphorylation	EASPSHLTLNSGLVE CCCCCCEEECCCCEE	20.61	24068923
1400	Phosphorylation	PSHLTLNSGLVESED CCCEEECCCCEECCC	36.29	23984901
1405	Phosphorylation	LNSGLVESEDL---- ECCCCEECCCC----	29.00	24068923

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1143	S	Phosphorylation	Kinase	AKT1	P31750	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1143	S	Phosphorylation		17242355
Phosphorylation at Ser-1143 by PKB/AKT1 modulates cytoskeletal organization and cell motility (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PALLD_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PALLD_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PALLD_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1146, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1009, AND MASSSPECTROMETRY.	17242355 [Abstract]
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells."; Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.; J. Proteome Res. 6:3174-3186(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1141; SER-1143 ANDSER-1146, AND MASS SPECTROMETRY.	17622165 [Abstract]

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