| UniProt ID | PAK5_MOUSE | |
|---|---|---|
| UniProt AC | Q8C015 | |
| Protein Name | Serine/threonine-protein kinase PAK 5 | |
| Gene Name | Pak5 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 719 | |
| Subcellular Localization | Mitochondrion. Cytoplasm. Nucleus. Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.. | |
| Protein Description | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity).. | |
| Protein Sequence | MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQLAPMKTIVRGNKSCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGAASRIQGHSEENGFITFSQYSSESDTTADYTTEKYRDRSLYGDDLDLYYKSSHAAKQNGHAMKMKHGDAYYPEMKSLKTDLAGFPVDYHTHLDSLRKSSEYGDLRWDYQRASSSSPLDYSFQLTPSRTAGTSRCSKESLAYSESDWGPSLDDYDRRPKSSYLHQTSPQPAMRQRSKSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVFSPPLSGSDTYPRGPTKLPQSQSKAGYSSGSHQYPSGYHKASLYHHPSLQTSSQYISTASYLSSLSISSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLDNFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSMLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 81 | Phosphorylation | NKSCKETSINGLLED CCCCCCCCCCHHHHH | 29899451 | ||
| 93 | Phosphorylation | LEDFDNISVTRSNSL HHHHCCCEEECCCCC | 29899451 | ||
| 99 | Phosphorylation | ISVTRSNSLRKESPP CEEECCCCCCCCCCC | 23140645 | ||
| 104 | Phosphorylation | SNSLRKESPPTPDQG CCCCCCCCCCCCCCC | 25521595 | ||
| 107 | Phosphorylation | LRKESPPTPDQGAAS CCCCCCCCCCCCHHH | 25521595 | ||
| 129 | Phosphorylation | ENGFITFSQYSSESD CCCEEEEEEECCCCC | - | ||
| 150 | Phosphorylation | TEKYRDRSLYGDDLD CHHHHHHHHHCCCCH | 29899451 | ||
| 205 | Phosphorylation | DYHTHLDSLRKSSEY CHHHHHHHHHHHHCC | 26370283 | ||
| 223 | Phosphorylation | RWDYQRASSSSPLDY CCEEECCCCCCCCCE | 24925903 | ||
| 224 | Phosphorylation | WDYQRASSSSPLDYS CEEECCCCCCCCCEE | 30372032 | ||
| 225 | Phosphorylation | DYQRASSSSPLDYSF EEECCCCCCCCCEEE | 24925903 | ||
| 226 | Phosphorylation | YQRASSSSPLDYSFQ EECCCCCCCCCEEEE | 25521595 | ||
| 230 | Phosphorylation | SSSSPLDYSFQLTPS CCCCCCCEEEEECCC | 24925903 | ||
| 231 | Phosphorylation | SSSPLDYSFQLTPSR CCCCCCEEEEECCCC | 23527152 | ||
| 235 | Phosphorylation | LDYSFQLTPSRTAGT CCEEEEECCCCCCCC | 24925903 | ||
| 252 | Phosphorylation | CSKESLAYSESDWGP CCHHHHCCCCCCCCC | 29899451 | ||
| 276 | Phosphorylation | KSSYLHQTSPQPAMR CHHHCCCCCCCHHHH | 29899451 | ||
| 277 | Phosphorylation | SSYLHQTSPQPAMRQ HHHCCCCCCCHHHHC | 29899451 | ||
| 286 | Phosphorylation | QPAMRQRSKSGSGLQ CHHHHCCCCCCCCCC | 19060867 | ||
| 288 | Phosphorylation | AMRQRSKSGSGLQEP HHHCCCCCCCCCCCC | 25521595 | ||
| 290 | Phosphorylation | RQRSKSGSGLQEPMM HCCCCCCCCCCCCCC | 25521595 | ||
| 315 | Phosphorylation | PQGHSYNSYTYPRLS CCCCCCCCCCCCCCC | 22322096 | ||
| 316 | Phosphorylation | QGHSYNSYTYPRLSE CCCCCCCCCCCCCCC | 22322096 | ||
| 317 | Phosphorylation | GHSYNSYTYPRLSEP CCCCCCCCCCCCCCC | 22322096 | ||
| 341 | Phosphorylation | DRAQMVFSPPLSGSD CCCCEEECCCCCCCC | 18056256 | ||
| 347 | Phosphorylation | FSPPLSGSDTYPRGP ECCCCCCCCCCCCCC | 29899451 | ||
| 350 | Phosphorylation | PLSGSDTYPRGPTKL CCCCCCCCCCCCCCC | - | ||
| 352 | Methylation | SGSDTYPRGPTKLPQ CCCCCCCCCCCCCCH | 58858773 | ||
| 366 | Phosphorylation | QSQSKAGYSSGSHQY HHHCCCCCCCCCCCC | 29899451 | ||
| 367 | Phosphorylation | SQSKAGYSSGSHQYP HHCCCCCCCCCCCCC | 29899451 | ||
| 377 | Phosphorylation | SHQYPSGYHKASLYH CCCCCCCCCCCCCCC | - | ||
| 602 | Phosphorylation | KEVPKRKSLVGTPYW CCCCCCCCCCCCCCC | 22322096 | ||
| 606 | Phosphorylation | KRKSLVGTPYWMAPE CCCCCCCCCCCCCHH | 26239621 | ||
| 608 | Phosphorylation | KSLVGTPYWMAPEVI CCCCCCCCCCCHHHH | 26239621 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PAK5_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PAK5_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PAK5_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PAK5_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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