PACR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PACR_HUMAN
• UniProt AC: P41586
• Protein Name: Pituitary adenylate cyclase-activating polypeptide type I receptor
• Gene Name: ADCYAP1R1
• Organism: Homo sapiens (Human).
• Sequence Length: 468
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract..
• Protein Sequence: MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	N-linked_Glycosylation	ANELMGFNDSSPGCP HHHHCCCCCCCCCCC	42.39	UniProtKB CARBOHYD
51 (in isoform 5)	Phosphorylation	-	28.33	30631047
60	N-linked_Glycosylation	GCPGMWDNITCWKPA CCCCCCCCEEEECCC	18.89	UniProtKB CARBOHYD
117	N-linked_Glycosylation	DMGVVSRNCTEDGWS HCCEEEECCCCCCCC	29.56	UniProtKB CARBOHYD
216	Phosphorylation	ILYAEQDSNHCFIST HHEECCCCCCEEEEE	28.33	68707719
300	N-linked_Glycosylation	DTGCWDMNDSTALWW CCCCCCCCCCEEEHH	37.29	UniProtKB CARBOHYD
337	Phosphorylation	ILVQKLQSPDMGGNE HHHHHHCCCCCCCCH	33.05	-
337 (in isoform 2)	Phosphorylation	-	33.05	-
374 (in isoform 4)	Phosphorylation	-	69.90	22210691
375	N-linked_Glycosylation	VFAFSPENVSKRERL EEEECCCCCCHHHHH	46.90	UniProtKB CARBOHYD
384 (in isoform 4)	Phosphorylation	-	8.31	22210691
395 (in isoform 2)	Phosphorylation	-	3.27	22210691
405 (in isoform 2)	Phosphorylation	-	38.30	22210691
434	Phosphorylation	DFKHRHPSLASSGVN EECCCCHHHHHCCCC	30.37	22210691
437	Phosphorylation	HRHPSLASSGVNGGT CCCHHHHHCCCCCCC	32.68	24719451
438	Phosphorylation	RHPSLASSGVNGGTQ CCHHHHHCCCCCCCE	40.95	25332170
444	Phosphorylation	SSGVNGGTQLSILSK HCCCCCCCEEEEEEC	27.95	22210691
447	Phosphorylation	VNGGTQLSILSKSSS CCCCCEEEEEECCCC	16.21	24719451
450	Phosphorylation	GTQLSILSKSSSQIR CCEEEEEECCCCCEE	28.90	25921289
452	Phosphorylation	QLSILSKSSSQIRMS EEEEEECCCCCEECC	31.67	25921289
453	Phosphorylation	LSILSKSSSQIRMSG EEEEECCCCCEECCC	29.96	25921289
454	Phosphorylation	SILSKSSSQIRMSGL EEEECCCCCEECCCC	36.40	25921289
459	Phosphorylation	SSSQIRMSGLPADNL CCCCEECCCCCHHHC	27.59	31437655
465 (in isoform 2)	Phosphorylation	-	33.41	24719451
468	Phosphorylation	LPADNLAT------- CCHHHCCC-------	42.16	68736991

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PACR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PACR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PACR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLUS_HUMAN	CLU	physical	25451228

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.