| UniProt ID | P2Y12_RAT | |
|---|---|---|
| UniProt AC | Q9EPX4 | |
| Protein Name | P2Y purinoceptor 12 | |
| Gene Name | P2ry12 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 343 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation.. | |
| Protein Sequence | MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | N-linked_Glycosylation | -MEVPGANATSANTT -CCCCCCCCCCCCCC | 50.06 | - | |
| 9 | Phosphorylation | EVPGANATSANTTSI CCCCCCCCCCCCCCC | 28.34 | 27097102 | |
| 10 | Phosphorylation | VPGANATSANTTSIP CCCCCCCCCCCCCCC | 19.67 | 27097102 | |
| 12 | N-linked_Glycosylation | GANATSANTTSIPGT CCCCCCCCCCCCCCC | 43.59 | - | |
| 13 | Phosphorylation | ANATSANTTSIPGTS CCCCCCCCCCCCCCC | 22.95 | 27097102 | |
| 14 | Phosphorylation | NATSANTTSIPGTST CCCCCCCCCCCCCCC | 25.19 | 27097102 | |
| 15 | Phosphorylation | ATSANTTSIPGTSTL CCCCCCCCCCCCCCC | 25.42 | 27097102 | |
| 61 | Phosphorylation | RIFFQIRSKSNFIIF HHHHHHHCCCCEEEE | 41.90 | 16641100 | |
| 63 | Phosphorylation | FFQIRSKSNFIIFLK HHHHHCCCCEEEEEC | 37.91 | 16641100 | |
| 72 | Phosphorylation | FIIFLKNTVISDLLM EEEEECCHHHHHHHH | 20.03 | 16641100 | |
| 75 | Phosphorylation | FLKNTVISDLLMILT EECCHHHHHHHHHHH | 20.19 | 16641100 | |
| 82 | Phosphorylation | SDLLMILTFPFKILS HHHHHHHHCCHHHHC | 20.52 | 16641100 | |
| 234 | Acetylation | VRTRGSAKAPKKRVN HHHCCCCCCCCCCHH | 67.90 | 25786129 | |
| 237 | Acetylation | RGSAKAPKKRVNIKV CCCCCCCCCCHHHHH | 59.06 | 25786129 | |
| 330 | Ubiquitination | TSGANKKKGQEGGDP CCCCCCCCCCCCCCC | 68.39 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of P2Y12_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of P2Y12_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of P2Y12_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of P2Y12_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
