P2RX7_MOUSE - dbPTM
P2RX7_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID P2RX7_MOUSE
UniProt AC Q9Z1M0
Protein Name P2X purinoceptor 7
Gene Name P2rx7
Organism Mus musculus (Mouse).
Sequence Length 595
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells..
Protein Sequence MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCGNCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEATNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4S-palmitoylation----MPACCSWNDVL
----CCCCCCHHHEE		1.2328680068
5S-palmitoylation---MPACCSWNDVLQ
---CCCCCCHHHEEE		6.0028680068
74N-linked_GlycosylationGIAEVTENVTEGGVT
CEEEEECCCCCCCCE		36.3219349973
125ADP-ribosylationLCPEYPRRGAQCSSD
CCCCCCCCCCCCCCC		40.05-
125ADP-ribosylationLCPEYPRRGAQCSSD
CCCCCCCCCCCCCCC		40.0517928361
133ADP-ribosylationGAQCSSDRRCKKGWM
CCCCCCCCCCCCCCC		48.09-
133ADP-ribosylationGAQCSSDRRCKKGWM
CCCCCCCCCCCCCCC		48.0917928361
144PhosphorylationKGWMDPQSKGIQTGR
CCCCCCCCCCCCCCC		37.93-
187N-linked_GlycosylationALLRSAENFTVLIKN
HHHHCCCCEEEEEEC		37.29-
202N-linked_GlycosylationNIHFPGHNYTTRNIL
CCCCCCCCCCCCCCC		41.58-
213N-linked_GlycosylationRNILPTMNGSCTFHK
CCCCCCCCCCEEEEC		41.52-
241N-linked_GlycosylationIFQEAGENFTEVAVQ
HHHHHCCCCHHEEEE		48.50-
306AcetylationYKENNVEKRTLIKAF
EHHCCCCHHHHHHHH		46.5315621151
390PhosphorylationYYRKKCESIMEPKPT
EHHHHCHHHCCCCCC		36.3825159016
443PhosphorylationFSDLSRLSLSLHDSP
HHHHHHHHCEECCCC		18.1422817900
445PhosphorylationDLSRLSLSLHDSPLT
HHHHHHCEECCCCCC		21.9323984901
449PhosphorylationLSLSLHDSPLTPGQS
HHCEECCCCCCCCCC		15.8623984901
452PhosphorylationSLHDSPLTPGQSEEI
EECCCCCCCCCCHHH		28.8523984901
456PhosphorylationSPLTPGQSEEIQLLH
CCCCCCCCHHHHHHH		43.0123984901
477S-palmitoylationSGDSPSWCQCGNCLP
CCCCCCCCCCCCCCC		2.5518971257
479S-palmitoylationDSPSWCQCGNCLPSR
CCCCCCCCCCCCCCC		3.7118971257
482S-palmitoylationSWCQCGNCLPSRLPE
CCCCCCCCCCCCCHH		3.4318971257
498S-palmitoylationRRALEELCCRRKPGR
HHHHHHHHCCCCCCC		1.6018971257
499S-palmitoylationRALEELCCRRKPGRC
HHHHHHHCCCCCCCE		8.0318971257
506S-palmitoylationCRRKPGRCITTSKLF
CCCCCCCEEEHHHHH		3.9318971257
519PhosphorylationLFHKLVLSRDTLQLL
HHHHHHCCHHHHHHH		22.1924719451
551MethylationRLRHRAYRCYATWRF
HHHHHHHHHHCCEEC		13.1430988741
574MethylationAILPSCCRWRIRKEF
ECCHHHHHHEECCCC		29.9930988747
584PhosphorylationIRKEFPKTEGQYSGF
ECCCCCCCCCCCCCC		45.6524719451
593PhosphorylationGQYSGFKYPY-----
CCCCCCCCCC-----		12.9024719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of P2RX7_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of P2RX7_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of P2RX7_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of P2RX7_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of P2RX7_MOUSE

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-74, AND MASS SPECTROMETRY.

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