dbPTM

P2C38_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	P2C38_ARATH
UniProt AC	Q9LHJ9
Protein Name	Probable protein phosphatase 2C 38 {ECO:0000305}
Gene Name	PP2C38 {ECO:0000303\|PubMed:27494702}
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	385
Subcellular Localization	Cell membrane Peripheral membrane protein .
Protein Description	Involved in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling. Negatively regulates immune responses by controlling the phosphorylation and activation status of BIK1, a central rate-limiting kinase in PTI signaling. Impairs the phosphorylation of the NADPH oxidase RBOHD by BIK1..
Protein Sequence	MVSSATILRMVAPCWRRPSVKGDHSTRDANGRCDGLLWYKDSGNHVAGEFSMSVIQANNLLEDHSKLESGPVSMFDSGPQATFVGVYDGHGGPEAARFVNKHLFDNIRKFTSENHGMSANVITKAFLATEEDFLSLVRRQWQIKPQIASVGACCLVGIICSGLLYIANAGDSRVVLGRLEKAFKIVKAVQLSSEHNASLESVREELRSLHPNDPQIVVLKHKVWRVKGIIQVSRSIGDAYLKKAEFNREPLLAKFRVPEVFHKPILRAEPAITVHKIHPEDQFLIFASDGLWEHLSNQEAVDIVNTCPRNGIARKLIKTALREAAKKREMRYSDLKKIDRGVRRHFHDDITVIVVFLDSHLVSRSTSRRPLLSISGGGDLAGPST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
77	Phosphorylation	GPVSMFDSGPQATFV CCCCCCCCCCCCEEE	40.90	27494702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of P2C38_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
77	S	Phosphorylation		27494702
Phosphorylation at Ser-77 induces dissociation of PP2C38 from BIK1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of P2C38_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of P2C38_ARATH

Related Literatures of Post-Translational Modification