OVOL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OVOL2_HUMAN
• UniProt AC: Q9BRP0
• Protein Name: Transcription factor Ovo-like 2
• Gene Name: OVOL2
• Organism: Homo sapiens (Human).
• Sequence Length: 275
• Subcellular Localization: Nucleus .
• Protein Description: Zinc-finger transcription repressor factor. [PubMed: 19700410 Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity Positively regulates neuronal differentiation (By similarity Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1]
• Protein Sequence: MPKVFLVKRRSLGVSVRSWDELPDEKRADTYIPVGLGRLLHDPPEDCRSDGGSSSGSGSSSAGEPGGAESSSSPHAPESETPEPGDAEGPDGHLATKQRPVARSKIKFTTGTCSDSVVHSCDLCGKGFRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFDLKRHVRTHTGIRPYKCNVCNKAFTQRCSLESHLKKIHGVQQQYAYKQRRDKLYVCEDCGYTGPTQEDLYLHVNSAHPGSSFLKKTSKKLAALLQGKLTSAHQENTSLSEEEERK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Methylation	-----MPKVFLVKRR -----CCCEEEEECC	44.30	115974531
8	Methylation	MPKVFLVKRRSLGVS CCCEEEEECCCCCCE	44.21	115974537
11	Phosphorylation	VFLVKRRSLGVSVRS EEEEECCCCCCEECC	33.24	30266825
30	Phosphorylation	PDEKRADTYIPVGLG CCCCCCCCEEECCHH	23.51	27642862
31	Phosphorylation	DEKRADTYIPVGLGR CCCCCCCEEECCHHH	12.08	27642862
49	Phosphorylation	DPPEDCRSDGGSSSG CCCHHHCCCCCCCCC	47.11	28348404
53	Phosphorylation	DCRSDGGSSSGSGSS HHCCCCCCCCCCCCC	27.19	28787133
54	Phosphorylation	CRSDGGSSSGSGSSS HCCCCCCCCCCCCCC	41.83	28787133
55	Phosphorylation	RSDGGSSSGSGSSSA CCCCCCCCCCCCCCC	38.38	28787133
57	Phosphorylation	DGGSSSGSGSSSAGE CCCCCCCCCCCCCCC	37.13	28348404
59	Phosphorylation	GSSSGSGSSSAGEPG CCCCCCCCCCCCCCC	23.87	28348404
60	Phosphorylation	SSSGSGSSSAGEPGG CCCCCCCCCCCCCCC	27.94	28348404
61	Phosphorylation	SSGSGSSSAGEPGGA CCCCCCCCCCCCCCC	41.83	28348404
70	Phosphorylation	GEPGGAESSSSPHAP CCCCCCCCCCCCCCC	34.68	28348404
71	Phosphorylation	EPGGAESSSSPHAPE CCCCCCCCCCCCCCC	26.75	28348404
72	Phosphorylation	PGGAESSSSPHAPES CCCCCCCCCCCCCCC	58.11	28348404
73	Phosphorylation	GGAESSSSPHAPESE CCCCCCCCCCCCCCC	23.74	28348404
79	Phosphorylation	SSPHAPESETPEPGD CCCCCCCCCCCCCCC	45.79	28348404
81	Phosphorylation	PHAPESETPEPGDAE CCCCCCCCCCCCCCC	42.08	28348404
204	Phosphorylation	IHGVQQQYAYKQRRD HHHHHHHHHHHHHCC	13.94	-
206	Phosphorylation	GVQQQYAYKQRRDKL HHHHHHHHHHHCCCE	11.61	-
241	Phosphorylation	NSAHPGSSFLKKTSK CCCCCCCHHHHHHHH	40.28	24719451
259	Phosphorylation	ALLQGKLTSAHQENT HHHHCHHCHHHHHCC	27.61	23927012
260	Phosphorylation	LLQGKLTSAHQENTS HHHCHHCHHHHHCCC	33.90	23927012
266	Phosphorylation	TSAHQENTSLSEEEE CHHHHHCCCCCHHHH	30.23	33259812
267	Phosphorylation	SAHQENTSLSEEEER HHHHHCCCCCHHHHH	41.29	23927012
269	Phosphorylation	HQENTSLSEEEERK- HHHCCCCCHHHHHC-	42.61	30278072

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OVOL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OVOL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OVOL2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of OVOL2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.