OTOG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OTOG_HUMAN
• UniProt AC: Q6ZRI0
• Protein Name: Otogelin
• Gene Name: OTOG
• Organism: Homo sapiens (Human).
• Sequence Length: 2925
• Subcellular Localization: Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted, extracellular space . Found in fiber-like structures during the maturation process of the tectorial membrane.
• Protein Description: Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity)..
• Protein Sequence: MGVLASALCWLLCVWLPWGEQAAESLRVQRLGERVVDSGRSGARGMRNVKGMRNGPAQTRVSSSSSHQEATLAMGDKATVVGGQQAEAPDSVAMSSWERRLHRAKCAPSYLFSCFNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLSGKGSYTLVGRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEIHLAKEVTHGGMRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGVYEQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDGGCVAPAECPCEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDGACVQSVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSACSPLVSGSPLDPCDVHLQAASYSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCATLAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEACGVDGGDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGHCHCKDGVMSCDSRAPAAACPAGQVFVNCSDLHTDLELSRERTCEQQLLNLSVSARGPCLSGCACPQGLLRHGDACFLPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKSTSDVSFSVIVENVNCYSSGMICRKFISINVGNSLIVFDDDSGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTPENLELTNPQEFGSSWAAVECPDTLDPRDMCVLNPLREPFAKKECSILLSEVFEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCASVSAYAHQCCQHGVAVDWRTPRLCPYDCDFFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHVTANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRLLDAKPSGAAYPICEWRYDACASPCFQTCRDPRAASCRDVPRVEGCVPVCPTPQVLDEVTQRCVYLEDCVEPAVWVPTEALGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPHTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSARTAPQDSMLVLLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSIVEGLAEALATTTEANTSTTCVPIAEQDCVRHICLEGQLIRVNQSQHCPQGAAPPRCGILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQSPDEMLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVTIDRFNRKVTVDLQPVWPPVSRYGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDCSPCLRMVSNRTFSACHRFVPPESFCELWIRDTKYVQQPCVALTVYVAMCHKFHVCIEWRRSDYCPFLCSSDSTYQACVTACEPPKTCQDGILGPLDPEHCQVLGEGCVCSEGTILHRRHSALCIPEAKCACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCLRFGEVALLLPTKDPCCLGTVCVCNQTLCEGLAPTCRPGHRLLTHFQEDSCCPSYSCECDPDLCEAELVPSCRQDQILITGRLGDSCCTSYFCACGDCPDSIPECQEGEALTVHRNTTELCCPLYQCVCENFRCPQVQCGLGTALVEVWSPDRCCPYKSCECDCDTIPVPRCHLWEKSQLDEEFMHSVENVCGCAKYECVKAPVCLSRELGVMQPGQTVVELSADGVCHTSRCTTVLDPLTNFYQINTTSVLCDIHCEANQEYEHPRDLAACCGSCRNVSCLFTFPNGTTSLFLPGASWIADCARHHCSSTPLGAVLVRSPISCPPLNETECAKVGGSVVPSLEGCCRTCKEDGRSCKKVTIRMTIRKNECRSSTPVNLVSCDGRCPSASIYNYNINTYARFCKCCREVGLQRRSVQLFCATNATWVPYTVQEPTDCACQWS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
142	Phosphorylation	GPRCQMVYNAGPERD CCCCEEEEECCCCHH	8.24	-
261 (in isoform 2)	Phosphorylation	-	3.52	20049867
264 (in isoform 2)	Phosphorylation	-	36.85	20049867
265 (in isoform 2)	Phosphorylation	-	15.66	20049867
328	Phosphorylation	QPPGPTTSSLPRPPC CCCCCCCCCCCCCCH	32.15	24719451
329	Phosphorylation	PPGPTTSSLPRPPCL CCCCCCCCCCCCCHH	40.06	24719451
585	Phosphorylation	PRRQVTLTQAGDVLL CCCCEEEEECCCEEE	13.65	22210691
602	Phosphorylation	QYKIIPPYTDDAFEI CCEECCCCCCCHHHH	19.90	29449344
603	Phosphorylation	YKIIPPYTDDAFEIR CEECCCCCCCHHHHH	32.93	29449344
613	Phosphorylation	AFEIRRLSSVFLRVR HHHHHHHHHEEEEEE	23.73	22210691
614	Phosphorylation	FEIRRLSSVFLRVRT HHHHHHHHEEEEEEC	22.83	22210691
621	Phosphorylation	SVFLRVRTNVGVRVL HEEEEEECCCCEEEE	31.25	30257219
629	Phosphorylation	NVGVRVLYDREGLRL CCCEEEEECCCCCEE	15.31	30257219
914	N-linked_Glycosylation	TCEQQLLNLSVSARG HHHHHHHCCCCCCCC	38.57	UniProtKB CARBOHYD
1367	Phosphorylation	LESLAKPSSFLYVSG HHHHCCCCCEEEEHH	32.77	25690035
1371	Phosphorylation	AKPSSFLYVSGAVLA CCCCCEEEEHHHHHH	7.20	25690035
1373	Phosphorylation	PSSFLYVSGAVLALR CCCEEEEHHHHHHHH	13.89	25690035
1413	Phosphorylation	YPICEWRYDACASPC CEEECCCCCCCCCCC	14.68	-
1418	Phosphorylation	WRYDACASPCFQTCR CCCCCCCCCCCCCCC	23.29	-
1423	Phosphorylation	CASPCFQTCRDPRAA CCCCCCCCCCCCCCC	6.83	-
1478	N-linked_Glycosylation	VPTEALGNETLPPSQ CCHHHHCCCCCCHHC	39.67	UniProtKB CARBOHYD
1604	Phosphorylation	AMETTRVTVIFAGSP CCEEEEEEEEECCCC	12.47	22210691
1612	N-linked_Glycosylation	VIFAGSPNITVSSRS EEECCCCCEEECCCC	44.23	UniProtKB CARBOHYD
1614	Phosphorylation	FAGSPNITVSSRSPP ECCCCCEEECCCCCC	22.45	22210691
1619	Phosphorylation	NITVSSRSPPAPRFP CEEECCCCCCCCCCC	36.86	22210691
1650	Phosphorylation	RTTPPQPSLTASPSS CCCCCCCCCCCCCCC	32.86	23090842
1652	Phosphorylation	TPPQPSLTASPSSRP CCCCCCCCCCCCCCC	29.44	23090842
1654	Phosphorylation	PQPSLTASPSSRPVA CCCCCCCCCCCCCCC	21.78	23090842
1656	Phosphorylation	PSLTASPSSRPVASP CCCCCCCCCCCCCCC	36.16	23090842
1657	Phosphorylation	SLTASPSSRPVASPG CCCCCCCCCCCCCCC	43.94	23090842
1662	Phosphorylation	PSSRPVASPGAISRS CCCCCCCCCCCCCCC	24.89	22210691
1669	Phosphorylation	SPGAISRSPTSSGSH CCCCCCCCCCCCCCC	26.24	24719451
1672	Phosphorylation	AISRSPTSSGSHKAV CCCCCCCCCCCCCEE	35.77	24719451
1675	Phosphorylation	RSPTSSGSHKAVLTP CCCCCCCCCCEEECH	24.62	22210691
1685	Phosphorylation	AVLTPAVTKVISRTG EEECHHHHHHHHCCC	23.00	22210691
1710	Phosphorylation	SSPSTPLTVAGTAAE CCCCCCEEEECCCHH	14.98	-
1743	Phosphorylation	EKGEAGHSQPMGSPA CCCCCCCCCCCCCCC	34.75	24532841
1748	Phosphorylation	GHSQPMGSPASPQPH CCCCCCCCCCCCCCC	15.84	24532841
1751	Phosphorylation	QPMGSPASPQPHPLP CCCCCCCCCCCCCCC	27.70	24532841
1769	Phosphorylation	PRPAQHTTMATRSPA CCCCCCCCCCCCCCC	11.59	24532841
1772	Phosphorylation	AQHTTMATRSPALPP CCCCCCCCCCCCCCC	22.36	24532841
1797	Phosphorylation	ATDGLAATPFMSLES CCCCCCCCCCCCCCC	16.08	-
1827	Phosphorylation	LPLAKVGTSAPVATP CCCCCCCCCCCCCCC	25.38	29514088
1828	Phosphorylation	PLAKVGTSAPVATPG CCCCCCCCCCCCCCC	25.33	29514088
1833	Phosphorylation	GTSAPVATPGPKASV CCCCCCCCCCCCCEE	29.07	29514088
1917	Phosphorylation	VSVVPRKSTTGKVAI EEEECCCCCCCCEEE	32.26	-
1918	Phosphorylation	SVVPRKSTTGKVAIL EEECCCCCCCCEEEE	42.47	-
1919	Phosphorylation	VVPRKSTTGKVAILS EECCCCCCCCEEEEE	41.94	-
2141	O-linked_Glycosylation	AIYILSQSPDEMLTV HHHHHHCCCCCCEEE	30.83	29351928
2147	O-linked_Glycosylation	QSPDEMLTVHVLDCK CCCCCCEEEEEEECC	13.78	29351928
2306	Phosphorylation	SCATTDCSPCLRMVS CCCCCCCHHHHHHHC	22.81	30631047
2348	Phosphorylation	QQPCVALTVYVAMCH CCCHHHHHHHHHHHH	10.47	28270605
2350	Phosphorylation	PCVALTVYVAMCHKF CHHHHHHHHHHHHHC	4.18	28270605
2495	Phosphorylation	EVALLLPTKDPCCLG EEEEECCCCCCCEEC	48.31	-
2792	Phosphorylation	DCARHHCSSTPLGAV HHHHHHCCCCCCCEE	32.65	26270265
2793	Phosphorylation	CARHHCSSTPLGAVL HHHHHCCCCCCCEEE	39.16	26270265
2794	Phosphorylation	ARHHCSSTPLGAVLV HHHHCCCCCCCEEEE	13.26	26270265
2803	Phosphorylation	LGAVLVRSPISCPPL CCEEEECCCCCCCCC	21.07	26270265
2806	Phosphorylation	VLVRSPISCPPLNET EEECCCCCCCCCCCC	24.77	26270265
2813	Phosphorylation	SCPPLNETECAKVGG CCCCCCCCCHHHCCC	34.98	26270265
2844	Phosphorylation	GRSCKKVTIRMTIRK CCCCCEEEEEEEECC	16.25	24719451
2925	Phosphorylation	TDCACQWS------- CCCCCCCC-------	12.40	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OTOG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OTOG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OTOG_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of OTOG_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.