OSTCN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OSTCN_HUMAN
• UniProt AC: P02818
• Protein Name: Osteocalcin
• Gene Name: BGLAP
• Organism: Homo sapiens (Human).
• Sequence Length: 100
• Subcellular Localization: Secreted.
• Protein Description: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium..
• Protein Sequence: MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPVPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	4-carboxyglutamate	VPYPDPLEPRREVCE CCCCCCCCCHHHHHH	41.99	-
68	Gamma-carboxyglutamic_acid	VPYPDPLEPRREVCE CCCCCCCCCHHHHHH	41.99	6967872
68	Gamma-carboxyglutamic_acid	VPYPDPLEPRREVCE CCCCCCCCCHHHHHH	41.99	6967872
72	4-carboxyglutamate	DPLEPRREVCELNPD CCCCCHHHHHHHCCC	53.45	-
72	Gamma-carboxyglutamic_acid	DPLEPRREVCELNPD CCCCCHHHHHHHCCC	53.45	6967872
72	Gamma-carboxyglutamic_acid	DPLEPRREVCELNPD CCCCCHHHHHHHCCC	53.45	6967872
75	4-carboxyglutamate	EPRREVCELNPDCDE CCHHHHHHHCCCHHH	57.67	-
75	Gamma-carboxyglutamic_acid	EPRREVCELNPDCDE CCHHHHHHHCCCHHH	57.67	6967872
75	Gamma-carboxyglutamic_acid	EPRREVCELNPDCDE CCHHHHHHHCCCHHH	57.67	6967872

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OSTCN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OSTCN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OSTCN_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of OSTCN_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Gamma-carboxyglutamic acid

"Isolation and sequence of the vitamin K-dependent protein from humanbone. Undercarboxylation of the first glutamic acid residue.";
Poser J.W., Esch F.S., Ling N.C., Price P.A.;
J. Biol. Chem. 255:8685-8691(1980).
Cited for: PROTEIN SEQUENCE OF 52-100, GAMMA-CARBOXYGLUTAMATION AT GLU-68; GLU-72AND GLU-75, AND ABSENCE OF HYDROXYLATION AT PRO-60.
PubMed: 6967872