dbPTM

OST1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OST1_SCHPO
UniProt AC	Q10176
Protein Name	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Gene Name	ost1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	450
Subcellular Localization	Endoplasmic reticulum membrane Single-pass type I membrane protein.
Protein Description	Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains..
Protein Sequence	MLVLKLLLWSIISGLSLAEQVWRNSNAIRTIDLRSTYTKTLTSLIIVNEGDEPQNTYRYFQQTSPGESVLSLSVSIKEEEKKGTNPIKVNNNVYDIPLQPPVKPGESRTLLIQAGLDGGVRPLPAAVDQDEEQYLVYLTTLYLDSPYTTDLQRTRLILPSAKIDTYTTYNIDGAELPNRVGNTLVYESRETITGEDNDLGEIYVRYEHTVPIPRGADLYVQIDMHEYRKMLEVSERVVFENHAAKLKSNFDRAKWYMGNFYNPVSTAINRVVYSLPRNSKDVYYTDEVGNITTSHMRVEPHQTWIELNPRYPVFGGWNYLFQLDWKMPYEEFRSSKNRREYLDIPLAWSPGDMIYEKAVWSYVFPEGATNIEIEMPVEISNSNVTKIHKFLDTLGRQVFTYEALNVTDGVPSDIVHISYEYNSSAFFLRIAIITTLLILLAAAAYMIWAP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
290	N-linked_Glycosylation	YYTDEVGNITTSHMR EEECCCCCEEECCCE	33.34	-
383	N-linked_Glycosylation	PVEISNSNVTKIHKF EEEECCCCHHHHHHH	50.13	-
405	N-linked_Glycosylation	VFTYEALNVTDGVPS EEEEEEECCCCCCCC	41.51	-
422	N-linked_Glycosylation	VHISYEYNSSAFFLR EEEEEECCCHHHHHH	19.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OST1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OST1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OST1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of OST1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OST1_SCHPO

Related Literatures of Post-Translational Modification