OPTN_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OPTN_RAT
• UniProt AC: Q8R5M4
• Protein Name: Optineurin
• Gene Name: Optn
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 585
• Subcellular Localization: Cytoplasm, perinuclear region. Golgi apparatus . Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes w
• Protein Description: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52..
• Protein Sequence: MSHQPLSCLTEKGDSSCETPGNGPSNMVHPNLDTFTPEELLQQMKELLVENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQLFEIQSKEAKERLKALSHENERLKEELGKLKEKSERPFEDITGRCGFPRTDLEQEVEQLKRQVEQEVEHLKIQVRRLQAEKADLLGIVSELQLKLNSGGSSEDSFVEIRMTEGEAEGAMKEMRNSAGPTRTDSISMGKCTEDARTCVEFEELTVSQLLLCLREGNQKVERLEIALREAKERISDFEKKANGHSAIETQTEGSTQKEEEDKDPESVGIEVETLNVQVASLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSATPSELNEKQELVYSNRKLELQVESMRSEIKMEQAKTEEEKSRLATLQATHDKLLQEHNKALRTIEELTKQQAEKVDKVQLQELSEKLELAEQALASKQLQMDEMKQTIAKQEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNDFEDGGSRQSLMEMQCRHGARTSDSDQQAYLFQRGAEDMSWQHGQQPRSIPIHSCPKCGEVLPDIDTLQIHVMDCII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
181	Phosphorylation	ELQLKLNSGGSSEDS HEEHHHCCCCCCCCC	55.77	28689409
184	Phosphorylation	LKLNSGGSSEDSFVE HHHCCCCCCCCCCEE	33.80	28689409
185	Phosphorylation	KLNSGGSSEDSFVEI HHCCCCCCCCCCEEE	49.01	28432305
188	Phosphorylation	SGGSSEDSFVEIRMT CCCCCCCCCEEEEEC	27.43	25532521
209	Phosphorylation	AMKEMRNSAGPTRTD HHHHHHHCCCCCCCC	25.00	25575281
213	Phosphorylation	MRNSAGPTRTDSISM HHHCCCCCCCCCCCC	45.33	25575281
215	Phosphorylation	NSAGPTRTDSISMGK HCCCCCCCCCCCCCC	36.25	28432305
217	Phosphorylation	AGPTRTDSISMGKCT CCCCCCCCCCCCCCC	18.89	29779826
219	Phosphorylation	PTRTDSISMGKCTED CCCCCCCCCCCCCCC	25.98	25575281
224	Phosphorylation	SISMGKCTEDARTCV CCCCCCCCCCHHHHH	40.15	25575281
298	Phosphorylation	EEDKDPESVGIEVET HCCCCHHHCCCEEEE	30.91	30181290
305	Phosphorylation	SVGIEVETLNVQVAS HCCCEEEEHHHHHHH	28.89	30181290
322	Phosphorylation	KELQEAHTKLSEAEL HHHHHHHHHHCHHHH	40.50	22673903
346	Phosphorylation	QALERKNSATPSELN HHHHHCCCCCHHHHH	36.23	29779826
348	Phosphorylation	LERKNSATPSELNEK HHHCCCCCHHHHHHH	27.45	23984901
350	Phosphorylation	RKNSATPSELNEKQE HCCCCCHHHHHHHHH	50.81	23984901
452	Ubiquitination	QLQMDEMKQTIAKQE HHCHHHHHHHHHHHH	42.09	-
515	Phosphorylation	NDFEDGGSRQSLMEM CCCCCCCCCHHHHHH	32.45	25575281
518	Phosphorylation	EDGGSRQSLMEMQCR CCCCCCHHHHHHHCC	28.68	25575281
530	Phosphorylation	QCRHGARTSDSDQQA HCCCCCCCCCHHHHH	36.03	21738781
531	Phosphorylation	CRHGARTSDSDQQAY CCCCCCCCCHHHHHH	29.57	23712012
533	Phosphorylation	HGARTSDSDQQAYLF CCCCCCCHHHHHHHH	36.77	27097102
538	Phosphorylation	SDSDQQAYLFQRGAE CCHHHHHHHHHCCCC	12.05	28689409
548	Phosphorylation	QRGAEDMSWQHGQQP HCCCCCCCCCCCCCC	35.59	29779826
557	Phosphorylation	QHGQQPRSIPIHSCP CCCCCCCCCCCCCCC	39.12	29779826

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OPTN_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OPTN_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OPTN_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of OPTN_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.