OPHN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OPHN1_MOUSE
• UniProt AC: Q99J31
• Protein Name: Oligophrenin-1
• Gene Name: Ophn1
• Organism: Mus musculus (Mouse).
• Sequence Length: 802
• Subcellular Localization: Cell junction, synapse . Cell projection, axon . Cell projection, dendritic spine . Cell projection, dendrite . Cytoplasm . Present in both presynaptic and postsynaptic sites..
• Protein Description: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity). Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation..
• Protein Sequence: MGHPPLEFSDCYLDSPDFRQRLKYYEEELERTNKFIKDVIKDGSALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVQNASDLLIKPLETFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLLEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWAKYYCRYEKETRMLTMIPMEQKPGAKQGPVDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQAPSEANRRLWMEAMDGKEPIYHTPITKQEEMELNEVGFKFVRKCINFIETKGIKTEGLYRTVGSNIQVQKLLYAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYKLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIKHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEDSQVPPVPPPRVTARRHKPITISKRLLREKTVFYTSSLDENKDESHHQTPNGTITSNLDPPKLLQHLKPPMQKSGETDPGRKSPSRPVSDCQSEPCLETDVGRLLFRLQDGGTKATPKASNGPVPGSGHTKTSSFHIRRPAPRPMAHHKEGDTDGFSKVRPPGEKQTIIRPPVRPPDPPCRSITPQKPEPKPETGSGNADEIPSSVVASRTRFFETASRKTGSSQGKLPGDES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
218	Phosphorylation	NSLTVELTQDFLPYK CCCEEEEECCCCCHH	16.76	-
370	Phosphorylation	MDGKEPIYHTPITKQ HCCCCCCCCCCCCHH	15.45	22817900
457	Phosphorylation	KFYLRNLSEPVMTYK HHHHHCCCCCHHHHH	43.32	24719451
592	Phosphorylation	RHKPITISKRLLREK CCCCEEEEHHHHHCC	11.76	-
606	Phosphorylation	KTVFYTSSLDENKDE CEEEEECCCCCCCCC	31.85	29899451
652	Phosphorylation	ETDPGRKSPSRPVSD CCCCCCCCCCCCCHH	27.09	26160508
654	Phosphorylation	DPGRKSPSRPVSDCQ CCCCCCCCCCCHHCC	57.20	24719451
658	Phosphorylation	KSPSRPVSDCQSEPC CCCCCCCHHCCCCCC	35.04	26160508
702	Phosphorylation	GSGHTKTSSFHIRRP CCCCCCCCCEEEECC	32.34	24719451
703	Phosphorylation	SGHTKTSSFHIRRPA CCCCCCCCEEEECCC	26.52	22817900
736	Phosphorylation	RPPGEKQTIIRPPVR CCCCCCCEEECCCCC	29.46	26824392
753	Phosphorylation	DPPCRSITPQKPEPK CCCCCCCCCCCCCCC	22.40	25338131
792	Phosphorylation	TASRKTGSSQGKLPG ECCCCCCCCCCCCCC	25.39	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OPHN1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OPHN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OPHN1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of OPHN1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.