| UniProt ID | ONEC2_HUMAN | |
|---|---|---|
| UniProt AC | O95948 | |
| Protein Name | One cut domain family member 2 | |
| Gene Name | ONECUT2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 504 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.. | |
| Protein Sequence | MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQELLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGGDYRPELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHHHHHHQRLSGNVSGSFTLMRDERGLPAMNNLYSPYKEMPGMSQSLSPLAATPLGNGLGGLHNAQQSLPNYGPPGHDKMLSPNFDAHHTAMLTRGEQHLSRGLGTPPAAMMSHLNGLHHPGHTQSHGPVLAPSRERPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNKDRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEMQITISQQLGLELTTVSNFFMNARRRSLEKWQDDLSTGGSSSTSSTCTKA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 79 | Methylation | RGAAGSLRGPPPPPT CCCCCCCCCCCCCCC | 58.22 | 115486007 | |
| 112 | Phosphorylation | AMVTSMASILDGGDY HHHHHHHHHHCCCCC | 18.29 | 22210691 | |
| 212 | Phosphorylation | PAMNNLYSPYKEMPG CCHHCCCCCHHHCCC | 25.56 | 28555341 | |
| 259 | Phosphorylation | PGHDKMLSPNFDAHH CCCCCCCCCCCCHHH | 17.82 | 23186163 | |
| 322 | Phosphorylation | PPSSSSGSQVATSGQ CCCCCCCCCCCCCCC | 24.35 | 28555341 | |
| 335 | Phosphorylation | GQLEEINTKEVAQRI CCCEECCHHHHHHHH | 33.95 | - | |
| 349 | Phosphorylation | ITAELKRYSIPQAIF HHHHHHHCCCCHHHH | 14.90 | - | |
| 367 | Phosphorylation | VLCRSQGTLSDLLRN HHHHCCCCHHHHHHC | 18.56 | - | |
| 369 | Phosphorylation | CRSQGTLSDLLRNPK HHCCCCHHHHHHCCC | 26.50 | - | |
| 460 | Phosphorylation | KEMQITISQQLGLEL CCEEEEHHHHHCCEE | 11.83 | 22210691 | |
| 468 | Phosphorylation | QQLGLELTTVSNFFM HHHCCEEEHHHHHHH | 18.77 | 22210691 | |
| 469 | Phosphorylation | QLGLELTTVSNFFMN HHCCEEEHHHHHHHH | 34.26 | - | |
| 481 | Phosphorylation | FMNARRRSLEKWQDD HHHHHHHHHHHHHHH | 38.78 | 22210691 | |
| 497 | Phosphorylation | STGGSSSTSSTCTKA CCCCCCCCCCCCCCC | 28.75 | 22468782 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ONEC2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ONEC2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ONEC2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ONEC2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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