OFUT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OFUT2_HUMAN
• UniProt AC: Q9Y2G5
• Protein Name: GDP-fucose protein O-fucosyltransferase 2
• Gene Name: POFUT2
• Organism: Homo sapiens (Human).
• Sequence Length: 429
• Subcellular Localization: Endoplasmic reticulum . Golgi apparatus . Mainly located in the endoplasmic reticulum.
• Protein Description: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13..
• Protein Sequence: MATLSFVFLLLGAVSWPPASASGQEFWPGQSAADILSGAASRRRYLLYDVNPPEGFNLRRDVYIRIASLLKTLLKTEEWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVIEYEQFIAESGGPFIDQVYVLQSYAEGWKEGTWEEKVDERPCIDQLLYSQDKHEYYRGWFWGYEETRGLNVSCLSVQGSASIVAPLLLRNTSARSVMLDRAENLLHDHYGGKEYWDTRRSMVFARHLREVGDEFRSRHLNSTDDADRIPFQEDWMKMKVKLGSALGGPYLGVHLRRKDFIWGHRQDVPSLEGAVRKIRSLMKTHRLDKVFVATDAVRKEYEELKKLLPEMVRFEPTWEELELYKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHEEREILGLDPKTTYNRFCGDQEKACEQPTHWKITY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Phosphorylation	DVYIRIASLLKTLLK HHHHHHHHHHHHHHH	31.68	24719451
182	Phosphorylation	YRGWFWGYEETRGLN HCCCCCCCCCCCCCC	10.94	-
185	Phosphorylation	WFWGYEETRGLNVSC CCCCCCCCCCCCCEE	20.35	-
189	N-linked_Glycosylation	YEETRGLNVSCLSVQ CCCCCCCCCEEEEEC	26.87	22588082
191	Phosphorylation	ETRGLNVSCLSVQGS CCCCCCCEEEEECCC	14.31	-
194	Phosphorylation	GLNVSCLSVQGSASI CCCCEEEEECCCHHH	19.40	-
209	N-linked_Glycosylation	VAPLLLRNTSARSVM HHHHHHCCCCCCHHH	38.05	UniProtKB CARBOHYD
259	N-linked_Glycosylation	EFRSRHLNSTDDADR HHHHHHCCCCCCHHC	36.42	22588082
390	Phosphorylation	GTSVSTFSFRIHEER CCCCEEEEEEEECCH	17.44	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OFUT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OFUT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OFUT2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of OFUT2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.