OFUT2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OFUT2_DROME
• UniProt AC: Q9W589
• Protein Name: GDP-fucose protein O-fucosyltransferase 2
• Gene Name: O-fut2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 490
• Subcellular Localization: Endoplasmic reticulum . Golgi apparatus . Mainly located in the endoplasmic reticulum.
• Protein Description: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of a number of protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families..
• Protein Sequence: MRGSWPRLGFPALLLLLHLLTGSDAAVRNGTAKREIGDSRGSSGTCVKGFLQEILPLPATCPPEVLGMRGAVYILYDVNISEGFNLRRDVYIRMAVFVRRLQRRRRFRHVRLVLPPWPRLYHWHSQGLQQSGLPWSHFFDLASLRRYAPVLDYEEFLAEQRLFGNPGAPLVHVGHAFRLQHYEVMLEQGIFRDKFERVTDKPCSEGSLSGGPLLQQAELRVGRFHCVRFQGSAGLLEKLLREAIDEDTAGPEDVDDMRTYALLSAETVLHDHWGDEHFWQARRSMRFARRLEQVAADFRRQALDTTDASAGVQRPAMWELERPKRNAKGGDYLCAHLRRGDFVRSRDATTPTLKAAAQQVKQLLRGFNMTTVFLATDATPYELMELKELFYRFRLVHFAPESNVQRRELKDGGVAVVDQLVCAYARYFVGTYESTFTYRIYEEREILGFTQASTFNTFCKALGGSCSRNAVWPIVWADGDSDSEEDSDPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	N-linked_Glycosylation	GSDAAVRNGTAKREI CCHHHHHCCCCCCCC	45.64	-
79	N-linked_Glycosylation	VYILYDVNISEGFNL EEEEEECCCCCCCCC	29.21	-
368	N-linked_Glycosylation	KQLLRGFNMTTVFLA HHHHCCCCCEEEEEE	29.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OFUT2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OFUT2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OFUT2_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of OFUT2_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.