ODPX_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ODPX_MOUSE
• UniProt AC: Q8BKZ9
• Protein Name: Pyruvate dehydrogenase protein X component, mitochondrial
• Gene Name: Pdhx
• Organism: Mus musculus (Mouse).
• Sequence Length: 501
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity)..
• Protein Sequence: MAASWRLHCNQPLLRYLLGFSSRRSLGLAQGAAAWPVDRGASWRWFHSTQLLQADPIKVLMPSLSPTMEQGNIVKWLRKEGEAVSAGDSLCEIETDKAVVTLDANDDGILAKIVVEEGAKNIQLGSLIALMVEEGEDWKQVEIPKDVSAPPPVSKPPAPTQPSPQPQIPCPARKEHKGTARFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVELKQMGKITESRPASAPPPSLSASVPPQATAGPSYPRPMTPPVSIPGQPNAAGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRRDLVKDDIKVSVNDFIIRAAAVTLKQMPGVNVTWDGEGPKQLPSVDISVAVATDKGLITPIIKDAAAKGIQEIADSVKVLSKKARDGKLMPEEYQGGSFSISNLGMFGIDEFAAVINPPQACILAVGRFRPVLKLTEDEEGNPQLQQHQLITVTMSSDSRVVDDELATRFLETFKANLENPMRLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	PIKVLMPSLSPTMEQ CEEEECCCCCCCCCC	27.75	29472430
65	Phosphorylation	KVLMPSLSPTMEQGN EEECCCCCCCCCCCC	23.74	29472430
67	Phosphorylation	LMPSLSPTMEQGNIV ECCCCCCCCCCCCHH	29.93	29472430
97	N6-lipoyllysine	LCEIETDKAVVTLDA CEEEECCCEEEEEEC	50.96	-
97	Lipoylation	LCEIETDKAVVTLDA CEEEECCCEEEEEEC	50.96	-
154	Phosphorylation	VSAPPPVSKPPAPTQ CCCCCCCCCCCCCCC	45.26	23684622
160	Phosphorylation	VSKPPAPTQPSPQPQ CCCCCCCCCCCCCCC	56.04	26745281
163	Phosphorylation	PPAPTQPSPQPQIPC CCCCCCCCCCCCCCC	26.75	26745281
170	S-nitrosylation	SPQPQIPCPARKEHK CCCCCCCCCCCCCCC	4.38	21278135
170	Glutathionylation	SPQPQIPCPARKEHK CCCCCCCCCCCCCCC	4.38	24333276
170	S-nitrosocysteine	SPQPQIPCPARKEHK CCCCCCCCCCCCCCC	4.38	-
185	Phosphorylation	GTARFRLSPAARNIL CCEEEEECHHHHHHH	14.29	29899451
194	Acetylation	AARNILEKHSLDASQ HHHHHHHHHCCCCCC	34.74	24062335
196	Phosphorylation	RNILEKHSLDASQGT HHHHHHHCCCCCCCC	38.73	27742792
200	Phosphorylation	EKHSLDASQGTATGP HHHCCCCCCCCCCCC	28.89	27742792
203	Phosphorylation	SLDASQGTATGPRGI CCCCCCCCCCCCCCC	17.26	26643407
205	Phosphorylation	DASQGTATGPRGIFT CCCCCCCCCCCCCCC	47.78	26643407
213	Acetylation	GPRGIFTKEDALKLV CCCCCCCHHHHHHHH	42.73	23201123
218	Acetylation	FTKEDALKLVELKQM CCHHHHHHHHHHHHH	52.81	23201123
292	Phosphorylation	RVIAKRLTESKSTVP HHHHHHHCCCCCCCC	42.10	23737553
294	Phosphorylation	IAKRLTESKSTVPHA HHHHHCCCCCCCCCE	27.03	23737553
307	S-nitrosocysteine	HAYATADCDLGAVLK CEEECCCCCHHHEEH	4.28	-
307	S-nitrosylation	HAYATADCDLGAVLK CEEECCCCCHHHEEH	4.28	21278135
321	Acetylation	KVRRDLVKDDIKVSV HHHHHHHCCCCEEEH	57.91	23864654
321	Succinylation	KVRRDLVKDDIKVSV HHHHHHHCCCCEEEH	57.91	26388266
325	Acetylation	DLVKDDIKVSVNDFI HHHCCCCEEEHHHHH	35.14	23864654
325	Succinylation	DLVKDDIKVSVNDFI HHHCCCCEEEHHHHH	35.14	26388266
341	Succinylation	RAAAVTLKQMPGVNV HHHHHHHHCCCCCCE	34.87	26388266
379	Acetylation	GLITPIIKDAAAKGI CCCCHHHHHHHHHCH	41.87	24062335
394	Succinylation	QEIADSVKVLSKKAR HHHHHHHHHHCHHHC	41.22	23806337
394	Succinylation	QEIADSVKVLSKKAR HHHHHHHHHHCHHHC	41.22	-
394	Acetylation	QEIADSVKVLSKKAR HHHHHHHHHHCHHHC	41.22	23864654
398	Acetylation	DSVKVLSKKARDGKL HHHHHHCHHHCCCCC	46.41	6567297
491	Acetylation	TRFLETFKANLENPM HHHHHHHHHHCCCCC	43.73	24062335

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Spop	Q6ZWS8	PMID:20811152

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
97	K	Lipoylation	Delipoylated at Lys-97 by SIRT4, delipoylation decreases the PHD complex activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ODPX_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ODPX_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.