| UniProt ID | ODPB_RAT | |
|---|---|---|
| UniProt AC | P49432 | |
| Protein Name | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | |
| Gene Name | Pdhb | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 359 | |
| Subcellular Localization | Mitochondrion matrix. | |
| Protein Description | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.. | |
| Protein Sequence | MAAVAGLVRGPLRQASGLLKRRFHRSAPAAVQLTVREAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSAGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDDNPVVMLENELMYGVAFELPTEAQSKDFLIPIGKAKIERQGTHITVVAHSRPVGHCLEAAAVLSKEGIECEVINLRTIRPMDIEAIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 52 | Acetylation | EELERDEKVFLLGEE HHHHHHCEEEECCHH | 42.44 | 22902405 | |
| 63 | Phosphorylation | LGEEVAQYDGAYKVS CCHHHHHCCCCCEEC | 13.45 | 30181290 | |
| 67 | Phosphorylation | VAQYDGAYKVSRGLW HHHCCCCCEECCCHH | 19.90 | 30181290 | |
| 68 | Acetylation | AQYDGAYKVSRGLWK HHCCCCCEECCCHHH | 32.95 | 25786129 | |
| 134 | O-linked_Glycosylation | AAKTYYMSAGLQPVP HHHHHHHCCCCCEEC | 11.76 | 28100784 | |
| 184 | Acetylation | PWNSEDAKGLIKSAI CCCCHHHHHHHHHHH | 67.58 | 22902405 | |
| 227 | Acetylation | DFLIPIGKAKIERQG CCEEEECCCEEEECC | 47.42 | 22902405 | |
| 258 | Acetylation | EAAAVLSKEGIECEV HHHHHHCCCCCEEEE | 56.66 | 26302492 | |
| 282 | O-linked_Glycosylation | DIEAIEASVMKTNHL CHHHHHHEEECCCCE | 15.23 | 28100784 | |
| 336 | Acetylation | DVPMPYAKILEDNSI CCCCCHHHHHCCCCC | 41.82 | 25786129 | |
| 347 | Acetylation | DNSIPQVKDIIFAIK CCCCHHHHHHHHHHH | 37.65 | 22902405 | |
| 354 | Acetylation | KDIIFAIKKTLNI-- HHHHHHHHHHHCC-- | 35.95 | 22902405 | |
| 355 | Acetylation | DIIFAIKKTLNI--- HHHHHHHHHHCC--- | 52.73 | 26302492 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ODPB_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ODPB_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ODPB_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ODPB_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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