ODPAT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ODPAT_MOUSE
• UniProt AC: P35487
• Protein Name: Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
• Gene Name: Pdha2
• Organism: Mus musculus (Mouse).
• Sequence Length: 391
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle..
• Protein Sequence: MRKMLTAVLSHVFSGMVQKPALRGLLSSLKFSNDATCDIKKCDLYRLEEGPPTSTVLTRAEALKYYRTMQVIRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPTDHVITSYRAHGFCYTRGLSVKSILAELTGRKGGCAKGKGGSMHMYGKNFYGGNGIVGAQVPLGAGVAFACKYLKNGQVCLALYGDGAANQGQVFEAYNMSALWKLPCVFICENNLYGMGTSNERSAASTDYHKKGFIIPGLRVNGMDILCVREATKFAADHCRSGKGPIVMELQTYRYHGHSMSDPGISYRSREEVHNVRSKSDPIMLLRERIISNNLSNIEELKEIDADVKKEVEDAAQFATTDPEPAVEDIANYLYHQDPPFEVRGAHKWLKYKSHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	PALRGLLSSLKFSND HHHHHHHHHCCCCCC	38.37	-
40	Acetylation	NDATCDIKKCDLYRL CCCCCCEEECCEEEC	33.81	19864895
78	Acetylation	VIRRMELKADQLYKQ HHHHHHCCHHHHHHH	36.29	2392835
84	Acetylation	LKADQLYKQKFIRGF CCHHHHHHHHCHHHH	56.45	2392843
86	Acetylation	ADQLYKQKFIRGFCH HHHHHHHHCHHHHHH	38.31	6269449
157	Phosphorylation	KGGSMHMYGKNFYGG CCCCEEEECCCCCCC	15.40	20495213
245	Acetylation	AASTDYHKKGFIIPG CCCCCHHCCCCCCCC	48.65	19864903
262	S-nitrosocysteine	VNGMDILCVREATKF ECCEEEEEEEHHHHH	2.50	-
262	S-nitrosylation	VNGMDILCVREATKF ECCEEEEEEEHHHHH	2.50	21278135
290	Phosphorylation	MELQTYRYHGHSMSD EEEEEEEECCCCCCC	11.18	17242355
294	Phosphorylation	TYRYHGHSMSDPGIS EEEECCCCCCCCCCC	25.27	27180971
296	Phosphorylation	RYHGHSMSDPGISYR EECCCCCCCCCCCCC	43.60	23737553
301	Phosphorylation	SMSDPGISYRSREEV CCCCCCCCCCCHHHH	22.02	23737553
302	Phosphorylation	MSDPGISYRSREEVH CCCCCCCCCCHHHHH	15.64	23737553
304	Phosphorylation	DPGISYRSREEVHNV CCCCCCCCHHHHHCC	35.49	23684622
344	Acetylation	KEIDADVKKEVEDAA HHCCHHHHHHHHHHH	43.70	19864911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
294	S	Phosphorylation	Kinase	PDK1	Q8BFP9	Uniprot
294	S	Phosphorylation	Kinase	PDK2	Q9JK42	Uniprot
294	S	Phosphorylation	Kinase	PDK3	Q922H2	Uniprot
294	S	Phosphorylation	Kinase	PDK4	O70571	Uniprot
301	S	Phosphorylation	Kinase	PDK3	Q922H2	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ODPAT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ODPAT_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ODPAT_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.