ODPA2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ODPA2_ARATH
• UniProt AC: Q8H1Y0
• Protein Name: Pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial
• Gene Name: IAR4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 393
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)..
• Protein Sequence: MALSRLSSRSNTFLKPAITALPSSIRRHVSTDSSPITIETAVPFTSHLCESPSRSVETSSEEILAFFRDMARMRRMEIAADSLYKAKLIRGFCHLYDGQEALAVGMEAAITKKDAIITSYRDHCTFIGRGGKLVDAFSELMGRKTGCSHGKGGSMHFYKKDASFYGGHGIVGAQIPLGCGLAFAQKYNKDEAVTFALYGDGAANQGQLFEALNISALWDLPAILVCENNHYGMGTATWRSAKSPAYFKRGDYVPGLKVDGMDALAVKQACKFAKEHALKNGPIILEMDTYRYHGHSMSDPGSTYRTRDEISGVRQVRDPIERVRKLLLTHDIATEKELKDMEKEIRKEVDDAVAQAKESPIPDASELFTNMYVKDCGVESFGADRKELKVTLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
292	Phosphorylation	LEMDTYRYHGHSMSD EEEECEEECCCCCCC	11.18	23776212
296	Phosphorylation	TYRYHGHSMSDPGST CEEECCCCCCCCCCC	25.27	27532006
298	Phosphorylation	RYHGHSMSDPGSTYR EECCCCCCCCCCCCC	43.60	24601666
302	Phosphorylation	HSMSDPGSTYRTRDE CCCCCCCCCCCCHHH	27.88	23776212
303	Phosphorylation	SMSDPGSTYRTRDEI CCCCCCCCCCCHHHC	23.96	23776212
304	Phosphorylation	MSDPGSTYRTRDEIS CCCCCCCCCCHHHCC	16.22	23776212
336	Acetylation	THDIATEKELKDMEK HCCCCCHHHHHHHHH	65.08	24727099
365	Phosphorylation	ESPIPDASELFTNMY HCCCCCHHHHHHCEE	42.06	19880383
369	Phosphorylation	PDASELFTNMYVKDC CCHHHHHHCEEECCC	31.53	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ODPA2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ODPA2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ODPA2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of ODPA2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.