ODP23_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ODP23_ARATH
• UniProt AC: Q5M729
• Protein Name: Dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial
• Gene Name: At1g54220
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 539
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)..
• Protein Sequence: MAYASRIINHSKKLKDVSTLLRRENAATIRYYSNTNRAPLNREDTFNSRLGYPPLERISICSTSTLPVSIIFSTTRSNLSSAMGRPIFGKEFSCLMQSARGFSSGSDLPPHQEIGMPSLSPTMTEGNIARWLKKEGDKVAPGEVLCEVETDKATVEMECMEEGYLAKIVKAEGSKEIQVGEVIAITVEDEEDIGKFKDYTPSSTADAAPTKAEPTPAPPKEEKVKQPSSPPEPKASKPSTPPTGDRVFASPLARKLAEDNNVPLSDIEGTGPEGRIVKADIDEYLASSGKGATAKPSKSTDSKAPALDYVDIPHSQIRKVTASRLAFSKQTIPHYYLTVDTCVDKLMALRSQLNSFKEASGGKRISVNDLVVKAAALALRKVPQCNSSWTDDYIRQFKNVNINVAVQTENGLYVPVVKDADRKGLSTIGEEVRLLAQKAKENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVVNPPQAAILAVGSAEKRVVPGNGPDQFNFASYMPVTLSCDHRVVDGAIGAEWLKAFKGYIENPKSMLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
152	N6-lipoyllysine	LCEVETDKATVEMEC EEEEECCCCEEEEEH		-
152	Lipoylation	LCEVETDKATVEMEC EEEEECCCCEEEEEH		-
199	Phosphorylation	DIGKFKDYTPSSTAD HHHCCCCCCCCCCCC		23111157
202	Phosphorylation	KFKDYTPSSTADAAP CCCCCCCCCCCCCCC		23111157
203	Phosphorylation	FKDYTPSSTADAAPT CCCCCCCCCCCCCCC		23111157
239	Phosphorylation	EPKASKPSTPPTGDR CCCCCCCCCCCCCCC		29654922
357	Acetylation	RSQLNSFKEASGGKR HHHHHHHHHHHCCCE		24727099
535	Acetylation	KGYIENPKSMLL--- HHHHHCCHHHCC---		24727099

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ODP23_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ODP23_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ODP23_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of ODP23_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.