NYNRI_HUMAN - dbPTM
NYNRI_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NYNRI_HUMAN
UniProt AC Q9P2P1
Protein Name Protein NYNRIN
Gene Name NYNRIN
Organism Homo sapiens (Human).
Sequence Length 1898
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description
Protein Sequence MLLSGGDPPAQEWFMVQTKSKPRVQRQRLQVQRIFRVKLNAFQSRPDTPYFWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLFLDCLCWSTLAYLVPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWEAEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDIIEWLSRFGISDSHSDPEVLICPPQQQKEAPAMVSVGESPGPFVDMGTLQNRGPENSKRLSSLGATGSLITAQSTPQEAANQLVRVGSNNQDGMDSAQEEGTVQATSSQDSTNHTQALLKQRQVQKIEDKLLFQPPVSALGVCPPWKAWTPGPAFGPLWPGAIAATFWRINELHSLHLAWLLSQACFNFPFWQRPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLGGEAALQNCPRPEISPKVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGEPGDQGSMQLDFKGLEEGPAPVLPTGQGKPVAQGGLTDQSVPGAQTVPETLKVPMAAAVPKAENPSRTQVPSAAPKLPTSRMMLAVHTEPAAPEVPLAPTKPTAQLMATAQKTVVNQPVLVAQVEPTTPKTPQAQKMPVAKTSPAGPKTPKAQAGPAATVSKAPAASKAPAAPKVPVTPRVSRAPKTPAAQKVPTDAGPTLDVARLLSEVQPTSRASVSLLKGQGQAGRQGPQSSGTLALSSKHQFQMEGLLGAWEGAPRQPPRHLQANSTVTSFQRYHEALNTPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREVTVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYDYRFMVKLAEETDGIIVTNEQIHILMNSSKKLMVKDRLLPFTFAGNLFMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKVWKTLPPSSASVTELSDDADSGPLESLPNMEEVREEKEERQDEEQRQGQGTQKAAEEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALDIDLLPGAASPYLGIPWDGKAPCQQVLAHLAQLTIPSNFTALSFFMGFMDSHRDAIPDYEALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLMAPNSQLPFRLEVTVSHVALTAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLDLSYASRTTADPEVREGRRVSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPAASMPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTPTYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGFLSSDGAPLPHPSLLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAPTVSPHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGDKKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLFCIPRNLIGSELKVIESPWPLRSTAPWSNLQIEVVGPVTISEEGHKHVLIVADPNTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQVASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVLTGGESRLTEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKASEKAENRRFKRESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPSSLMKAFAKSGTPLSFKVLEQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationQEWFMVQTKSKPRVQ
HHHEEEECCCCCCHH		26.35-
21MethylationFMVQTKSKPRVQRQR
EEEECCCCCCHHHHH		38.10-
65UbiquitinationPRENMGKAKEYLKGL
CHHHHHHHHHHHHHH		12.2727667366
191PhosphorylationAVQELLLSLVRDAAG
HHHHHHHHHHHHHCC		25.4524719451
321UbiquitinationNHTQALLKQRQVQKI
HHHHHHHHHHHHHHH		44.26-
417UbiquitinationLPLNLEWKQKELAPL
CCCCCEECHHHCCCC		41.9632015554
453PhosphorylationNCPRPEISPKVTSLL
CCCCCCCCCCEEEEE		19.6017929957
457PhosphorylationPEISPKVTSLLVVPG
CCCCCCEEEEEEECC		21.5623403867
458PhosphorylationEISPKVTSLLVVPGS
CCCCCEEEEEEECCC		23.7723403867
465PhosphorylationSLLVVPGSSDVKDKV
EEEEECCCCCHHHHH		19.8023403867
466PhosphorylationLLVVPGSSDVKDKVS
EEEECCCCCHHHHHH		52.9523403867
593PhosphorylationPEVPLAPTKPTAQLM
CCCCCCCCCCHHHHH		44.01-
620PhosphorylationLVAQVEPTTPKTPQA
EEEEECCCCCCCCCH		42.0728555341
621PhosphorylationVAQVEPTTPKTPQAQ
EEEECCCCCCCCCHH		33.2427251275
624PhosphorylationVEPTTPKTPQAQKMP
ECCCCCCCCCHHCCC		23.1028555341
635PhosphorylationQKMPVAKTSPAGPKT
HCCCCCCCCCCCCCC		30.1522210691
641UbiquitinationKTSPAGPKTPKAQAG
CCCCCCCCCCCCCCC		76.2422505724
642PhosphorylationTSPAGPKTPKAQAGP
CCCCCCCCCCCCCCC		32.9122210691
652PhosphorylationAQAGPAATVSKAPAA
CCCCCCCCCCCCCCC		27.6722210691
660PhosphorylationVSKAPAASKAPAAPK
CCCCCCCCCCCCCCC		31.3026055452
712PhosphorylationPTSRASVSLLKGQGQ
CCCHHHHHHHCCCCC		26.0324719451
715UbiquitinationRASVSLLKGQGQAGR
HHHHHHHCCCCCCCC		55.2532015554
727PhosphorylationAGRQGPQSSGTLALS
CCCCCCCCCCCEEEC		33.5928842319
734PhosphorylationSSGTLALSSKHQFQM
CCCCEEECCCCCCCH		31.5623312004
735PhosphorylationSGTLALSSKHQFQME
CCCEEECCCCCCCHH		34.7023312004
890PhosphorylationMVKLAEETDGIIVTN
HHHHHHCCCCEEEEH		30.9119413330
896PhosphorylationETDGIIVTNEQIHIL
CCCCEEEEHHHHEEH		23.7219413330
906PhosphorylationQIHILMNSSKKLMVK
HHEEHHCCCCCEEEC		29.57-
907PhosphorylationIHILMNSSKKLMVKD
HEEHHCCCCCEEECC		28.89-
945UbiquitinationPTLDEFLKKPNRLDT
CCHHHHHHCCCCCCC		72.0727667366
1021PhosphorylationAEEDDLDSSLASVFR
HHHCCCCHHHHHHHC		34.2526074081
1022PhosphorylationEEDDLDSSLASVFRV
HHCCCCHHHHHHHCC		27.8526074081
1025PhosphorylationDLDSSLASVFRVECP
CCCHHHHHHHCCCCC		27.3826074081
1120PhosphorylationALVGPLHSLLKQKPD
HHHHHHHHHHHCCCC		42.9824719451
1190PhosphorylationKHPIAYTSKPLLPDE
CCCEEEECCCCCCCC		21.4324719451
1286PhosphorylationLGENRLLTPAASMPR
HCCCCCCCCHHHCCH		18.57-
1290PhosphorylationRLLTPAASMPRFFQV
CCCCCHHHCCHHHHC		31.2724719451
1419PhosphorylationSYIISLTSGLSSLPF
HHHHHHHCCHHCCCE		42.92-
1422PhosphorylationISLTSGLSSLPFIYR
HHHHCCHHCCCEEEE		33.10-
1435PhosphorylationYRTSYRGSLFAVTVD
EEECCCCCEEEEEHH		16.0029083192
1440PhosphorylationRGSLFAVTVDTLAKQ
CCCEEEEEHHHHHHC		14.8329083192
1443PhosphorylationLFAVTVDTLAKQGAQ
EEEEEHHHHHHCCCC		25.0329083192
1457PhosphorylationQGGGQWWSLPKDVPA
CCCCCCCCCCCCCCC		31.6624825855
1564AcetylationQRPEETYKKLRLLGW
CCHHHHHHHHHHHCC		53.397976785
1703PhosphorylationALGAQVASLSRDLQF
HHHHHHHHHCCCCCC		28.2027174698
1705PhosphorylationGAQVASLSRDLQFPC
HHHHHHHCCCCCCCC		22.6627174698
1836PhosphorylationGDQVLLLSLPRNGSS
CCEEEEEECCCCCCC		35.9819276368
1843PhosphorylationSLPRNGSSAKWVGPF
ECCCCCCCCCEECCE		34.9519276368
1876PhosphorylationPEKLGCIYPSSLMKA
HHHCCCCCCHHHHHH		10.9229514088
1878PhosphorylationKLGCIYPSSLMKAFA
HCCCCCCHHHHHHHH		21.0929514088
1879PhosphorylationLGCIYPSSLMKAFAK
CCCCCCHHHHHHHHH		28.1629514088
1882UbiquitinationIYPSSLMKAFAKSGT
CCCHHHHHHHHHHCC		45.7232015554
1887PhosphorylationLMKAFAKSGTPLSFK
HHHHHHHHCCCCEEE		44.4627251275
1889PhosphorylationKAFAKSGTPLSFKVL
HHHHHHCCCCEEEEC		28.3124719451
1892PhosphorylationAKSGTPLSFKVLEQ-
HHHCCCCEEEECCC-		24.9924719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NYNRI_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NYNRI_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NYNRI_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NYNRI_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NYNRI_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-660; THR-890 ANDTHR-896, AND MASS SPECTROMETRY.

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