NUDT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUDT4_HUMAN
• UniProt AC: Q9NZJ9
• Protein Name: Diphosphoinositol polyphosphate phosphohydrolase 2
• Gene Name: NUDT4
• Organism: Homo sapiens (Human).
• Sequence Length: 180
• Subcellular Localization: Cytoplasm .
• Protein Description: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA..
• Protein Sequence: MMKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGMEPEEEPGGAAVREVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLEKLKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMKFKPNQ -------CCCCCCCC	6.26	22814378
3 (in isoform 2)	Ubiquitination	-	49.27	-
3	Ubiquitination	-----MMKFKPNQTR -----CCCCCCCCCC	49.27	-
5	Ubiquitination	---MMKFKPNQTRTY ---CCCCCCCCCCCC	37.22	-
38	Phosphorylation	EDEVLLVSSSRYPDQ CCEEEEEECCCCCCC	23.67	30206219
39	Phosphorylation	DEVLLVSSSRYPDQW CEEEEEECCCCCCCE	16.03	30206219
40	Phosphorylation	EVLLVSSSRYPDQWI EEEEEECCCCCCCEE	28.47	30206219
53	Sulfoxidation	WIVPGGGMEPEEEPG EECCCCCCCCCCCCC	9.81	30846556
68	Phosphorylation	GAAVREVYEEAGVKG CHHHHHHHHHHCCCC	11.87	28796482
74	Methylation	VYEEAGVKGKLGRLL HHHHHCCCCHHHHHH	49.78	-
74 (in isoform 2)	Ubiquitination	-	49.78	-
76 (in isoform 2)	Ubiquitination	-	41.89	-
76	Methylation	EEAGVKGKLGRLLGI HHHCCCCHHHHHHEE	41.89	-
93	Phosphorylation	NQDRKHRTYVYVLTV CCCCCCCEEEEEEEH	19.63	22468782
127	Ubiquitination	FKVEDAIKVLQCHKP EEHHHHHHHHCCCCC	38.32	-
131	S-nitrosylation	DAIKVLQCHKPVHAE HHHHHHCCCCCCCHH	3.78	22178444
133	Ubiquitination	IKVLQCHKPVHAEYL HHHHCCCCCCCHHHH	57.26	-
134 (in isoform 2)	Ubiquitination	-	10.24	-
140	Phosphorylation	KPVHAEYLEKLKLGC CCCCHHHHHHHCCCC	3.35	27642862
142	Ubiquitination	VHAEYLEKLKLGCSP CCHHHHHHHCCCCCC	48.61	-
148	Phosphorylation	EKLKLGCSPANGNST HHHCCCCCCCCCCCC	25.83	22199227
149	Phosphorylation	KLKLGCSPANGNSTV HHCCCCCCCCCCCCC	33.55	24719451
154	Phosphorylation	CSPANGNSTVPSLPD CCCCCCCCCCCCCCC	31.98	25159151
155	Phosphorylation	SPANGNSTVPSLPDN CCCCCCCCCCCCCCC	40.20	25159151
158	Phosphorylation	NGNSTVPSLPDNNAL CCCCCCCCCCCCCEE	48.47	26074081
335	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUDT4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUDT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUDT4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NUDT4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.