NUDC_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUDC_RAT
• UniProt AC: Q63525
• Protein Name: Nuclear migration protein nudC
• Gene Name: Nudc
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 332
• Subcellular Localization: Cytoplasm, cytoskeleton. Nucleus. A small proportion is nuclear, in a punctate pattern (By similarity). In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubu
• Protein Description: Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity)..
• Protein Sequence: MGGEQEEERFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFFIGGEEGMAEKLITQTFNHHNQLAQKARREKRARQETERREKAERAARLAKEAKAETPGPQIKELTDEEAERLQLEIDQKKDAENHEVQLKNGSLDSPGKQDAEEEEDEEDEKDKGKLKPNLGNGADLPNYRWTQTLSELDLAVPFRVSFRLKGKDVVVDIQRRHLRVGLKGQAPVIDGELYNEVKVEESSWLIEDGKVVTVHLEKINKMEWWNRLVTSDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQEILKKFMDQHPEMDFSKAKFN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	FSFLRRKTDFFIGGE HHHHHHCCCEECCCC	35.91	27097102
99	Phosphorylation	AKEAKAETPGPQIKE HHHHHCCCCCCCHHH	38.10	29779826
108	Phosphorylation	GPQIKELTDEEAERL CCCHHHCCHHHHHHH	42.32	29779826
136	Phosphorylation	EVQLKNGSLDSPGKQ CEEECCCCCCCCCCC	38.10	23298284
139	Phosphorylation	LKNGSLDSPGKQDAE ECCCCCCCCCCCCCC	40.62	30411139
176	Phosphorylation	DLPNYRWTQTLSELD CCCCCCCEEEHHHHC	11.59	23984901
178	Phosphorylation	PNYRWTQTLSELDLA CCCCCEEEHHHHCCC	25.52	23984901
180	Phosphorylation	YRWTQTLSELDLAVP CCCEEEHHHHCCCCC	39.23	23984901
240	Acetylation	SWLIEDGKVVTVHLE EEEEECCEEEEEEEE	45.94	-
260	Phosphorylation	EWWNRLVTSDPEINT HHHHHHHCCCCCCCC	31.81	27097102
261	Phosphorylation	WWNRLVTSDPEINTK HHHHHHCCCCCCCCC	43.63	27097102
267	Phosphorylation	TSDPEINTKKINPEN CCCCCCCCCCCCCCC	39.10	27097102
275	Phosphorylation	KKINPENSKLSDLDS CCCCCCCCCCCCCCH	33.06	23984901
278	Phosphorylation	NPENSKLSDLDSETR CCCCCCCCCCCHHHH	39.60	23984901
282	Phosphorylation	SKLSDLDSETRSMVE CCCCCCCHHHHHHHH	48.44	28432305
284	Phosphorylation	LSDLDSETRSMVEKM CCCCCHHHHHHHHHH	31.81	28432305
286	Phosphorylation	DLDSETRSMVEKMMY CCCHHHHHHHHHHHH	34.30	25575281
299	Phosphorylation	MYDQRQKSMGLPTSD HHHHHHHHCCCCCCH	15.11	-
316	Acetylation	KKQEILKKFMDQHPE HHHHHHHHHHHHCCC	42.34	22902405
327	Phosphorylation	QHPEMDFSKAKFN-- HCCCCCHHHHCCC--	27.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUDC_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
275	S	Phosphorylation	Phosphorylation on Ser-275 and Ser-327 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis.	-
327	S	Phosphorylation	Phosphorylation on Ser-275 and Ser-327 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUDC_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NUDC_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.