NUDC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUDC_MOUSE
• UniProt AC: O35685
• Protein Name: Nuclear migration protein nudC
• Gene Name: Nudc
• Organism: Mus musculus (Mouse).
• Sequence Length: 332
• Subcellular Localization: Cytoplasm, cytoskeleton. Nucleus. A small proportion is nuclear, in a punctate pattern (By similarity). In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubu
• Protein Description: Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity)..
• Protein Sequence: MGGEQEEERFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFFIGGEEGMAEKLITQTFNHHNQLAQKARREKRARQETERREKAERAARLAKEAKAETPGPQIKELTDEEAERLQLEIDQKKDAEDQEAQLKNGSLDSPGKQDAEDEEDEEDEKDKGKLKPNLGNGADLPNYRWTQTLAELDLAVPFRVSFRLKGKDVVVDIQRRHLRVGLKGQPPVVDGELYNEVKVEESSWLIEDGKVVTVHLEKINKMEWWNRLVTSDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQEILKKFMDQHPEMDFSKAKFN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Ubiquitination	HHNQLAQKARREKRA HHHHHHHHHHHHHHH	37.95	27667366
96	Malonylation	ARLAKEAKAETPGPQ HHHHHHHHCCCCCCC	48.09	26320211
99	Phosphorylation	AKEAKAETPGPQIKE HHHHHCCCCCCCHHH	38.10	26824392
108	Phosphorylation	GPQIKELTDEEAERL CCCHHHCCHHHHHHH	42.32	25521595
136	Phosphorylation	EAQLKNGSLDSPGKQ HHHHHCCCCCCCCCC	38.10	22942356
139	Phosphorylation	LKNGSLDSPGKQDAE HHCCCCCCCCCCCCC	40.62	25521595
191	Phosphorylation	LAVPFRVSFRLKGKD CCCCEEEEEEECCCE	10.61	26239621
197	Ubiquitination	VSFRLKGKDVVVDIQ EEEEECCCEEEEEEE	45.84	-
213	Ubiquitination	RHLRVGLKGQPPVVD HHCCCCCCCCCCCCC	49.96	27667366
240	Acetylation	SWLIEDGKVVTVHLE EEEEECCEEEEEEEE	45.94	-
251	Acetylation	VHLEKINKMEWWNRL EEEEECCCCHHHHHH	41.49	22826441
260	Phosphorylation	EWWNRLVTSDPEINT HHHHHHHCCCCCCCC	31.81	28066266
261	Phosphorylation	WWNRLVTSDPEINTK HHHHHHCCCCCCCCC	43.63	26745281
275	Phosphorylation	KKINPENSKLSDLDS CCCCCCCCCCCCCCH	33.06	25619855
276	Ubiquitination	KINPENSKLSDLDSE CCCCCCCCCCCCCHH	64.69	-
278	Phosphorylation	NPENSKLSDLDSETR CCCCCCCCCCCHHHH	39.60	25619855
282	Phosphorylation	SKLSDLDSETRSMVE CCCCCCCHHHHHHHH	48.44	26643407
284	Phosphorylation	LSDLDSETRSMVEKM CCCCCHHHHHHHHHH	31.81	26643407
286	Phosphorylation	DLDSETRSMVEKMMY CCCHHHHHHHHHHHH	34.30	26643407
293	Phosphorylation	SMVEKMMYDQRQKSM HHHHHHHHHHHHHHC	12.86	28576409
299	Phosphorylation	MYDQRQKSMGLPTSD HHHHHHHHCCCCCCH	15.11	22817900
304	Phosphorylation	QKSMGLPTSDEQKKQ HHHCCCCCCHHHHHH	54.58	22817900
305	Phosphorylation	KSMGLPTSDEQKKQE HHCCCCCCHHHHHHH	36.89	22817900
310	Ubiquitination	PTSDEQKKQEILKKF CCCHHHHHHHHHHHH	53.51	27667366
327	Phosphorylation	QHPEMDFSKAKFN-- HCCCCCHHHHCCC--	27.69	23984901
328	Acetylation	HPEMDFSKAKFN--- CCCCCHHHHCCC---	56.44	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUDC_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
275	S	Phosphorylation	Phosphorylation on Ser-275 and Ser-327 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis.	-
327	S	Phosphorylation	Phosphorylation on Ser-275 and Ser-327 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUDC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NUDC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.