NUCL1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUCL1_ARATH
• UniProt AC: Q9FVQ1
• Protein Name: Nucleolin 1
• Gene Name: NUCL1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 557
• Subcellular Localization: Nucleus, nucleolus . Found in the dense fibrillar component region of the nucleolus.
• Protein Description: Involved in pre-rRNA processing and ribosome assembly. [PubMed: 17108323]
• Protein Sequence: MGKSKSATKVVAEIKATKPLKKGKREPEDDIDTKVSLKKQKKDVIAAVQKEKAVKKVPKKVESSDDSDSESEEEEKAKKVPAKKAASSSDESSDDSSSDDEPAPKKAVAATNGTVAKKSKDDSSSSDDDSSDEEVAVTKKPAAAAKNGSVKAKKESSSEDDSSSEDEPAKKPAAKIAKPAAKDSSSSDDDSDEDSEDEKPATKKAAPAAAKAASSSDSSDEDSDEESEDEKPAQKKADTKASKKSSSDESSESEEDESEDEEETPKKKSSDVEMVDAEKSSAKQPKTPSTPAAGGSKTLFAANLSFNIERADVENFFKEAGEVVDVRFSTNRDDGSFRGFGHVEFASSEEAQKALEFHGRPLLGREIRLDIAQERGERGERPAFTPQSGNFRSGGDGGDEKKIFVKGFDASLSEDDIKNTLREHFSSCGEIKNVSVPIDRDTGNSKGIAYLEFSEGKEKALELNGSDMGGGFYLVVDEPRPRGDSSGGGGFGRGNGRFGSGGGRGRDGGRGRFGSGGGRGRDGGRGRFGSGGGRGSDRGRGRPSFTPQGKKTTFGDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	KVPKKVESSDDSDSE HCCCCCCCCCCCCCC	41.89	23776212
64	Phosphorylation	VPKKVESSDDSDSES CCCCCCCCCCCCCCC	31.75	23776212
67	Phosphorylation	KVESSDDSDSESEEE CCCCCCCCCCCCHHH	48.29	23776212
69	Phosphorylation	ESSDDSDSESEEEEK CCCCCCCCCCHHHHH	47.15	23776212
71	Phosphorylation	SDDSDSESEEEEKAK CCCCCCCCHHHHHHH	55.02	23776212
87	Phosphorylation	VPAKKAASSSDESSD CCHHHHHCCCCCCCC	34.92	23776212
88	Phosphorylation	PAKKAASSSDESSDD CHHHHHCCCCCCCCC	36.76	23776212
89	Phosphorylation	AKKAASSSDESSDDS HHHHHCCCCCCCCCC	42.79	23776212
92	Phosphorylation	AASSSDESSDDSSSD HHCCCCCCCCCCCCC	44.02	23776212
93	Phosphorylation	ASSSDESSDDSSSDD HCCCCCCCCCCCCCC	43.31	23776212
96	Phosphorylation	SDESSDDSSSDDEPA CCCCCCCCCCCCCCC	36.41	23776212
97	Phosphorylation	DESSDDSSSDDEPAP CCCCCCCCCCCCCCC	44.79	23776212
98	Phosphorylation	ESSDDSSSDDEPAPK CCCCCCCCCCCCCCH	53.70	23776212
119	Phosphorylation	NGTVAKKSKDDSSSS CCCEEECCCCCCCCC	40.38	23776212
123	Phosphorylation	AKKSKDDSSSSDDDS EECCCCCCCCCCCCC	42.10	23776212
124	Phosphorylation	KKSKDDSSSSDDDSS ECCCCCCCCCCCCCC	40.64	23776212
125	Phosphorylation	KSKDDSSSSDDDSSD CCCCCCCCCCCCCCH	41.56	23776212
126	Phosphorylation	SKDDSSSSDDDSSDE CCCCCCCCCCCCCHH	47.18	23776212
130	Phosphorylation	SSSSDDDSSDEEVAV CCCCCCCCCHHHHEC	46.84	23776212
131	Phosphorylation	SSSDDDSSDEEVAVT CCCCCCCCHHHHECC	56.91	23776212
138	Phosphorylation	SDEEVAVTKKPAAAA CHHHHECCCCHHHHH	24.50	23776212
156	Phosphorylation	SVKAKKESSSEDDSS CCEEEECCCCCCCCC	48.30	23776212
157	Phosphorylation	VKAKKESSSEDDSSS CEEEECCCCCCCCCC	38.55	23776212
158	Phosphorylation	KAKKESSSEDDSSSE EEEECCCCCCCCCCC	55.08	23776212
162	Phosphorylation	ESSSEDDSSSEDEPA CCCCCCCCCCCCCCC	48.35	23776212
163	Phosphorylation	SSSEDDSSSEDEPAK CCCCCCCCCCCCCCC	44.75	23776212
164	Phosphorylation	SSEDDSSSEDEPAKK CCCCCCCCCCCCCCC	53.68	23776212
184	Phosphorylation	AKPAAKDSSSSDDDS CCCCCCCCCCCCCCC	31.26	23776212
185	Phosphorylation	KPAAKDSSSSDDDSD CCCCCCCCCCCCCCC	43.95	23776212
186	Phosphorylation	PAAKDSSSSDDDSDE CCCCCCCCCCCCCCC	41.56	23776212
187	Phosphorylation	AAKDSSSSDDDSDED CCCCCCCCCCCCCCC	47.18	23776212
191	Phosphorylation	SSSSDDDSDEDSEDE CCCCCCCCCCCCCCC	50.31	23776212
195	Phosphorylation	DDDSDEDSEDEKPAT CCCCCCCCCCCCCCH	44.92	23776212
202	Phosphorylation	SEDEKPATKKAAPAA CCCCCCCHHHHHHHH	41.42	23776212
214	Phosphorylation	PAAAKAASSSDSSDE HHHHHHHHCCCCCCC	34.92	23776212
215	Phosphorylation	AAAKAASSSDSSDED HHHHHHHCCCCCCCC	33.18	23776212
216	Phosphorylation	AAKAASSSDSSDEDS HHHHHHCCCCCCCCC	38.73	23776212
218	Phosphorylation	KAASSSDSSDEDSDE HHHHCCCCCCCCCCC	41.45	23776212
219	Phosphorylation	AASSSDSSDEDSDEE HHHCCCCCCCCCCCC	50.43	23776212
223	Phosphorylation	SDSSDEDSDEESEDE CCCCCCCCCCCCCCC	44.89	23776212
227	Phosphorylation	DEDSDEESEDEKPAQ CCCCCCCCCCCHHHH	48.58	23776212
245	Phosphorylation	DTKASKKSSSDESSE HHHHHHHCCCCCCCC	38.52	23776212
246	Phosphorylation	TKASKKSSSDESSES HHHHHHCCCCCCCCC	51.17	23776212
247	Phosphorylation	KASKKSSSDESSESE HHHHHCCCCCCCCCC	53.11	23776212
250	Phosphorylation	KKSSSDESSESEEDE HHCCCCCCCCCCCCC	44.38	23776212
251	Phosphorylation	KSSSDESSESEEDES HCCCCCCCCCCCCCC	42.99	23776212
253	Phosphorylation	SSDESSESEEDESED CCCCCCCCCCCCCCC	48.51	23776212
258	Phosphorylation	SESEEDESEDEEETP CCCCCCCCCCCCCCC	63.77	23776212
264	Phosphorylation	ESEDEEETPKKKSSD CCCCCCCCCCCCCCC	43.62	23776212
269	Phosphorylation	EETPKKKSSDVEMVD CCCCCCCCCCCEEEE	40.42	23776212
270	Phosphorylation	ETPKKKSSDVEMVDA CCCCCCCCCCEEEEH	55.33	30291188
274	Sulfoxidation	KKSSDVEMVDAEKSS CCCCCCEEEEHHHHC	3.12	23289948
280	Phosphorylation	EMVDAEKSSAKQPKT EEEEHHHHCCCCCCC	27.34	19880383
281	Phosphorylation	MVDAEKSSAKQPKTP EEEHHHHCCCCCCCC	51.02	19880383
287	Phosphorylation	SSAKQPKTPSTPAAG HCCCCCCCCCCCCCC	29.20	23776212
289	Phosphorylation	AKQPKTPSTPAAGGS CCCCCCCCCCCCCCC	52.86	23776212
290	Phosphorylation	KQPKTPSTPAAGGSK CCCCCCCCCCCCCCC	20.39	23776212
296	Phosphorylation	STPAAGGSKTLFAAN CCCCCCCCCCEEEEE	22.88	23776212
329	Phosphorylation	EVVDVRFSTNRDDGS CEEEEEEEECCCCCC	17.76	19880383
347	Phosphorylation	FGHVEFASSEEAQKA CEEEEECCHHHHHHH	43.53	23776212
348	Phosphorylation	GHVEFASSEEAQKAL EEEEECCHHHHHHHH	35.71	23776212
385	Phosphorylation	RGERPAFTPQSGNFR CCCCCCCCCCCCCCC	23.64	23776212
388	Phosphorylation	RPAFTPQSGNFRSGG CCCCCCCCCCCCCCC	36.59	23776212
393	Phosphorylation	PQSGNFRSGGDGGDE CCCCCCCCCCCCCCC	42.88	19880383
411	Phosphorylation	FVKGFDASLSEDDIK EEEECCCCCCHHHHH	33.98	23776212
413	Phosphorylation	KGFDASLSEDDIKNT EECCCCCCHHHHHHH	36.16	30291188
420	Phosphorylation	SEDDIKNTLREHFSS CHHHHHHHHHHHHHH	23.38	19376835
450	Phosphorylation	GNSKGIAYLEFSEGK CCCCCEEEEEECCCC	12.58	30407730
454	Phosphorylation	GIAYLEFSEGKEKAL CEEEEEECCCCCEEE	35.74	30291188
500	Phosphorylation	RGNGRFGSGGGRGRD CCCCCCCCCCCCCCC	31.39	29797451
515	Phosphorylation	GGRGRFGSGGGRGRD CCCCCCCCCCCCCCC	31.39	29797451
536	Phosphorylation	GSGGGRGSDRGRGRP CCCCCCCCCCCCCCC	23.83	29797451
546	Phosphorylation	GRGRPSFTPQGKKTT CCCCCCCCCCCCCCC	21.02	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUCL1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUCL1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUCL1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of NUCL1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, AND MASSSPECTROMETRY.
PubMed: 19376835